Uracil mustard

Uracil mustard

File:Uramustine.svg
Pharmacokinetic data
Protein binding	5%
Excretion	Renal
Identifiers
IUPAC name 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
CAS Number	66-75-1
PubChem CID	6194
DrugBank	APRD00130
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C8H11Cl2N3O2
Molar mass	252.097 g/mol

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Clinical Trials
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Definitions
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Overview

Uracil mustard or uramustine is a chemotherapy drug which belongs to the class of alkylating agents. It is used in lymphatic malignancies such as non-Hodgkin's lymphoma. It works by damaging DNA, primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division. The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects.

Chemically it is a derivative of nitrogen mustard and uracil.