Small-sized vessel vasculitis with focal neurological sign: Difference between revisions

Revision as of 15:36, 10 April 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

			Symptoms					Physical examination			Lab Findings				Imaging				Histopathology
Diseases			Clinical manifestations								Para-clinical findings									Gold standard	Additional findings
			Symptoms					Physical examination			Para-clinical findings
			Headache	Fever	Weight loss	Arthralgia	Claudication	Bruit	HTN	Focal neurological disorder	Biomarker	CBC	ESR	Other	CT scan	Angiography	Ultrasound/ Echocardiography	Other	Histopathology
Small-Vessel Vasculitis	ANCA-associated vasculitis	Microscopic polyangiitis^[1]	+	-	-	+/-	-	-	-	+	Anti-PR3 antibody (C-ANCA) (40%), Anti-MPO antibody (P-ANCA) (60%)	Leukocytosis, Normocytic anemia	↑	Proteinuria, Erythrocyte casts	Suspected pancreatitis	Mesenteric angiography for differentiating from polyarteritis nodosa	-	Bilateral nodular, and patchy opacities in CXR	Glomerulonephritis with focal necrosis, crescent formation, and lack or paucity of immunoglobulin deposits	Histological confirmation	Rash, Hemoptysis
		Granulomatosis with polyangiitis (Wegener’s)^[2]	+	+/-	+/-	-	-	-	-	+	Anti-PR3 antibody (C-ANCA) (90%), Anti-MPO antibody (P-ANCA) (10%)	Leukocytosis, Normochromic normocytic anemia	↑	↑Cr or BUN, Hypoalbuminemia	Consolidation, Patchy or diffuse ground-glass opacities	Occlusion or stenosis of LAD and RCA in coronary angiography	-	Single or multiple nodules and masses with cavitation in CXR	Parenchymal necrosis, Granulomatous inflammation	Histological confirmation	Conjunctivitis, Episcleritis, Uveitis, Optic nerve vasculitis
		Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)^[3]	+/-	-	-	+	-	-	-	+	Anti-MPO antibody (P-ANCA) (40%), Eotaxin-3	Eosinophilia, Anemia	↑	↑Cr or BUN, Proteinuria, Erythrocyte casts, ↑IgE levels	Significant enlargement of peripheral pulmonary arteries	Myocardial ischemia and infarction in coronary angiography	Congestive heart failure (CHF) in echocardiography	Extensive air-space opacities in CXR	Small necrotizing granulomas with eosinophilic core surrounded by macrophages and epithelioid giant cells	Histological confirmation	Allergic rhinitis, Asthma, Urticarial rash
		Hydralazine-associated ANCA-associated vasculitis^[4]	-	-	-	+	-	-	-	+/-	Anti-MPO antibody (P-ANCA), Anti-histone antibodies	Anemia	-	↑Cr or BUN, Hypoalbuminemia	Bilateral pulmonary infiltrates	Aneurysms or occlusions of the visceral arteries	-	-	Pauci-immune necrotizing and crescentic glomerulonephritis	Histological confirmation	Sinusitis, Hemoptysis
	Immune complex small-vessel vasculitis	Hepatitis C virus-associated cryoglobulinemic vasculitis^[5]	+/-	+/-	+	+	-	-	+	+/-	HCV RNA, Cryoglobulins	Leukocytosis, Anemia	↑	↓Serum C4, Positive RF	Increased hepatic echogenicity	-	Hepatomegaly, Splenomegaly	Increased hepatic echogenicity in MRI	Vasculitic skin, Antigen infilteration in lesions	HCV RNA, Histological confirmation	Palpable purpura, Microscopic hematuria
	Cardiovascular disease	Infective Endocarditis^[6]	+	+	+	-	-	-	-	+	NT-proBNP	Normochromic-normocytic anemia	↑	Hyperglobulinemia, Cryoglobulinemia	Metastatic infections, such as splenic infarct, renal infarcts, or psoas abscess	-	Vegetation, abscess, or new dehiscence of a prosthetic valvein echocardiography	Vertebral osteomyelitis in MRI	Vegetation or intracardiac abscess demonstrating active endocarditis	Echocardiography (TTE)	Janeway lesions, Osler nodes, Roth spots, Vertebral osteomyelitis
	Cardiovascular disease	Leukocytoclastic Vasculitis^[7]	+	-	-	+	-	-	-	+	IgM, IgA, IgG	Leukocytosis, Anemia	↑	Hypocomplementemia	-	Vascular stenosis and obstruction in visceral angiography	-	-	Perivascular inflammatory infiltrate of neutrophils with leukocytoclasia (releasing nuclear debris)	Histological confirmation	Palpable purpura, Petechiae
	Pulmonary disease	Non-Small Cell Lung Cancer^[8]	-	+/-	+	-	-	-	-	+/-	EGFR, ROS1, EML4-ALK, PD-L1	Leukocytosis, Anemia	↑	Hypercalcemia, Hyponatremia	Pulmonary lesion or mass	-	Pulmonary marginal lesions	Staging and response to treatment in PET-CT	Adenocarcinoma, Squamous cell carcinoma	High resolution CT-scan	Cough, Hemoptysis
	Pulmonary disease	Small Cell Lung Cancer^[9]	-	+/-	+	-	-	-	-	+/-	p53, Thyroid transcription factor-1 (TTF1)	Anemia	↑	Hyponatremia	Large hilar mass with bulky mediastinal adenopathy	-	Endobronchial ultrasound (EBUS)	Standard staging	Spindled cells with dark nuclei, scant cytoplasm, and fine, granular nuclear chromatin	High resolution CT-scan	Cough, Hemoptysis
	Renal disease	Acute Poststreptococcal Glomerulonephritis^[10]	-	-	-	+	-	-	+	+/-	Antistreptolysin-O (ASO) titers	Leukocytosis	↑	Hypocomplementemia	-	-	Normal to slightly enlarged kidneys	Central venous congestion in a hilar pattern in CXR	Hypercellularity of endothelial and mesangial cells, Infiltration of the glomerular tuft with polymorphonuclear cells	Histological confirmation	Hematuria
	Hematologic disease	Hemolytic-Uremic Syndrome^[11]	+	+	-	+	-	-	+	+	C5b-9, ADAMTS13	Anemia, Thrombocytopenia, Reticulocytosis	↑	↑Lactate dehydrogenase (LDH), Hypercalcemia	Thalami, brainstem, or cerebellum abnormality	Cerebral microangiopathy or hypertension	Hypoechoic kidney	Abnormal hyperintensity in the brain cisterns in MRI	Microthromboses include fibrin thrombi that may occlude the glomerular tuft	Clinical findings coupled with laboratory abnormalities	Hematuria, Proteinuria
		Chronic Lymphocytic Leukemia (CLL)^[12]	+	+	+	+	+/-	-	-	+/-	CD5, CD19, CD20, IgV_H	Absolute lymphocytosis, Smudge cells	↑	Flow cytometry	Staging	-	-	-	Large atypical cells, cleaved cells, and prolymphocytes	Chromosomal and genetic testing	Easy bruising
		Multiple Myeloma^[13]	+	-	+	+	+	+	+/-	+/-	Ig light chain	Anemia, Thrombocytopenia, Leukopenia	↑	Bone marrow aspiration and biopsy, ↑Cr	Osseous involvement and lytic lesions	Peripheral zone of increased vascularity in lesions	-	Punched-out lesion in skull X-ray	Clonal proliferation of plasma cells	Protein electrophoresis plus conventional X-rays	Constipation
		Non-Hodgkin Lymphoma^[14]	+	+	+	+	+/-	+/-	+/-	+/-	MYC, BCL2, BCL6, and TP53	Lymphocytosis, Anemia, Thrombocytopenia	↑	↑Lactate dehydrogenase (LDH), Hypercalcemia	Enlarged lymph nodes, Hepatosplenomegaly, Filling defects in the liver and spleen	-	Hepatosplenomegaly	Mediastinal lymphadenopathy	Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern	Surgically excised tissue biopsy	Easy bruising, Testicular mass, Skin lesion
		Serum Sickness^[15]	+	+	-	+/-	+/-	-	-	+/-	IL-1, IL-6, TNF	Leukopenia	↑	Polyclonal gammopathy, ↑Cr, Cryoglobulinemia	-	-	-	-	Arteritic lesions are focal, necrotizing, and inflammatory involving all layers of the artery	Clinical findings coupled with laboratory abnormalities	Hematuria, Skin rash
		Disseminated Intravascular Coagulation^[16]	+/-	+	-	+/-	-	-	+	+	Fibrin degradation product (FDP)	Thrombocytopenia, Schistocytes	↑	↑D-dimer, aPTT and PT	Intracranial hemorrhage	-	-	-	Ischemia and necrosis due to fibrin deposition in small and medium-sized vessels	Clinical findings coupled with laboratory abnormalities	Acral cyanosis, Hemorrhagic skin infarctions
		Idiopathic Thrombocytopenic Purpura^[17]	+	+/-	-	+	-	-	-	+	FC gamma receptors (FCGR) IIb	Anemia, Thrombocytopenia	-	HIV, ANA	R/O other causes	-	R/O splenomegaly	-	Increased number of normal morphologic megakaryocytes	Clinical findings coupled with thrombocytopenia	Easy bruising, Purpura
	Systemic disease	Sarcoidosis^[18]	+	+	+	+	-	-	-	+/-	IL-2 and IFN-γ	Mild anemia	↑	↑ACE, ↑1, 25-dihydroxyvitamin D	Active alveolitis or fibrosis	-	Hepatosplenomegaly	Bilateral hilar adenopathy	Noncaseating granulomas (NCGs)	Histological confirmation	Heart block, Ocular lesion
		Legionella Infection^[19]	+	+	+	+	-	-	-	+/-	Inflammatory cytokines	Leukocytosis with left shift, Thrombocytosis	↑	↑D-dimer, FDP, Hyponatremia	Pleural effusion	-	-	Nonspecific and indistinguishable CXR	Intra-alveolar inflammation, Microabscesses in the parenchyma	Sputum culture	Cough, Diarrhea
		Systemic lupus erythematosus^[20]	+	+	+	+	-	-	+	+	Anti dsDNA, ANA	Leukopenia, Lymphopenia, Anemia, Thrombocytopenia	↑	↑Cr or BUN, ↑ALT or AST, Proteinuria	Interstitial lung disease, Pneumonitis, Pulmonary emboli, Alveolar hemorrhage	Aneurysms	Pericardial effusion, pulmonary hypertension, or verrucous Libman-Sacks endocarditis in echocardiography	Central nervous system (CNS) lupus white-matter changes in MRI	Staging lupus nephritis	Anti-dsDNA antibody test	Skin rashes or photosensitivity

References

↑ Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.
↑ Kubaisi B, Abu Samra K, Foster CS (2016). "Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations". Intractable Rare Dis Res. 5 (2): 61–9. doi:10.5582/irdr.2016.01014. PMC 4869584. PMID 27195187.
↑ Keogh KA, Specks U (April 2006). "Churg-Strauss syndrome". Semin Respir Crit Care Med. 27 (2): 148–57. doi:10.1055/s-2006-939518. PMID 16612766.
↑ Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW (2013). "Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report". J Med Case Rep. 7: 20. doi:10.1186/1752-1947-7-20. PMC 3565908. PMID 23316942.
↑ Guo QY, Wu M, Wang YW, Sun GD (2017). "Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report". Exp Ther Med. 14 (2): 1395–1398. doi:10.3892/etm.2017.4671. PMC 5525644. PMID 28810602.
↑ McDonald JR (2009). "Acute infective endocarditis". Infect Dis Clin North Am. 23 (3): 643–64. doi:10.1016/j.idc.2009.04.013. PMC 2726828. PMID 19665088.
↑ Einhorn J, Levis JT (2015). "Dermatologic Diagnosis: Leukocytoclastic Vasculitis". Perm J. 19 (3): 77–8. doi:10.7812/TPP/15-001. PMC 4500485. PMID 26176572.
↑ Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). "Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship". Mayo Clin Proc. 83 (5): 584–94. doi:10.4065/83.5.584. PMC 2718421. PMID 18452692.
↑ Jackman DM, Johnson BE (2005). "Small-cell lung cancer". Lancet. 366 (9494): 1385–96. doi:10.1016/S0140-6736(05)67569-1. PMID 16226617.
↑ VanDeVoorde RG (January 2015). "Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis". Pediatr Rev. 36 (1): 3–12, quiz 13. doi:10.1542/pir.36-1-3. PMID 25554106.
↑ Corrigan JJ, Boineau FG (November 2001). "Hemolytic-uremic syndrome". Pediatr Rev. 22 (11): 365–9. PMID 11691946.
↑ Byrd JC, Stilgenbauer S, Flinn IW (2004). "Chronic lymphocytic leukemia". Hematology Am Soc Hematol Educ Program: 163–83. doi:10.1182/asheducation-2004.1.163. PMID 15561682.
↑ Michels TC, Petersen KE (March 2017). "Multiple Myeloma: Diagnosis and Treatment". Am Fam Physician. 95 (6): 373–383. PMID 28318212.
↑ Shankland KR, Armitage JO, Hancock BW (September 2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
↑ Lin RY (January 1986). "Serum sickness syndrome". Am Fam Physician. 33 (1): 157–62. PMID 2867672.
↑ Venugopal A (2014). "Disseminated intravascular coagulation". Indian J Anaesth. 58 (5): 603–8. doi:10.4103/0019-5049.144666. PMC 4260307. PMID 25535423.
↑ Nomura S (2016). "Advances in Diagnosis and Treatments for Immune Thrombocytopenia". Clin Med Insights Blood Disord. 9: 15–22. doi:10.4137/CMBD.S39643. PMC 4948655. PMID 27441004.
↑ Chiarchiaro J, Chen BB, Gibson KF (2016). "New molecular targets for the treatment of sarcoidosis". Curr Opin Pulm Med. 22 (5): 515–21. doi:10.1097/MCP.0000000000000304. PMC 5152532. PMID 27454074.
↑ Murdoch DR (January 2003). "Diagnosis of Legionella infection". Clin. Infect. Dis. 36 (1): 64–9. doi:10.1086/345529. PMID 12491204.
↑ Tsokos, George C. (2011). "Systemic Lupus Erythematosus". New England Journal of Medicine. 365 (22): 2110–2121. doi:10.1056/NEJMra1100359. ISSN 0028-4793.

Template:WH Template:WS

[pmid20688249-1] Chung SA, Seo P (2010). "Microscopic polyangiitis". Rheum Dis Clin North Am. 36 (3): 545–58. doi:10.1016/j.rdc.2010.04.003. PMC 2917831. PMID 20688249.

[pmid27195187-2] Kubaisi B, Abu Samra K, Foster CS (2016). "Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations". Intractable Rare Dis Res. 5 (2): 61–9. doi:10.5582/irdr.2016.01014. PMC 4869584. PMID 27195187.

[pmid16612766-3] Keogh KA, Specks U (April 2006). "Churg-Strauss syndrome". Semin Respir Crit Care Med. 27 (2): 148–57. doi:10.1055/s-2006-939518. PMID 16612766.

[pmid23316942-4] Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW (2013). "Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report". J Med Case Rep. 7: 20. doi:10.1186/1752-1947-7-20. PMC 3565908. PMID 23316942.

[pmid28810602-5] Guo QY, Wu M, Wang YW, Sun GD (2017). "Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report". Exp Ther Med. 14 (2): 1395–1398. doi:10.3892/etm.2017.4671. PMC 5525644. PMID 28810602.

[pmid19665088-6] McDonald JR (2009). "Acute infective endocarditis". Infect Dis Clin North Am. 23 (3): 643–64. doi:10.1016/j.idc.2009.04.013. PMC 2726828. PMID 19665088.

[pmid26176572-7] Einhorn J, Levis JT (2015). "Dermatologic Diagnosis: Leukocytoclastic Vasculitis". Perm J. 19 (3): 77–8. doi:10.7812/TPP/15-001. PMC 4500485. PMID 26176572.

[pmid18452692-8] Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). "Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship". Mayo Clin Proc. 83 (5): 584–94. doi:10.4065/83.5.584. PMC 2718421. PMID 18452692.

[pmid16226617-9] Jackman DM, Johnson BE (2005). "Small-cell lung cancer". Lancet. 366 (9494): 1385–96. doi:10.1016/S0140-6736(05)67569-1. PMID 16226617.

[pmid25554106-10] VanDeVoorde RG (January 2015). "Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis". Pediatr Rev. 36 (1): 3–12, quiz 13. doi:10.1542/pir.36-1-3. PMID 25554106.

[pmid11691946-11] Corrigan JJ, Boineau FG (November 2001). "Hemolytic-uremic syndrome". Pediatr Rev. 22 (11): 365–9. PMID 11691946.

[pmid15561682-12] Byrd JC, Stilgenbauer S, Flinn IW (2004). "Chronic lymphocytic leukemia". Hematology Am Soc Hematol Educ Program: 163–83. doi:10.1182/asheducation-2004.1.163. PMID 15561682.

[pmid28318212-13] Michels TC, Petersen KE (March 2017). "Multiple Myeloma: Diagnosis and Treatment". Am Fam Physician. 95 (6): 373–383. PMID 28318212.

[pmid22835603-14] Shankland KR, Armitage JO, Hancock BW (September 2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.

[pmid2867672-15] Lin RY (January 1986). "Serum sickness syndrome". Am Fam Physician. 33 (1): 157–62. PMID 2867672.

[pmid25535423-16] Venugopal A (2014). "Disseminated intravascular coagulation". Indian J Anaesth. 58 (5): 603–8. doi:10.4103/0019-5049.144666. PMC 4260307. PMID 25535423.

[pmid27441004-17] Nomura S (2016). "Advances in Diagnosis and Treatments for Immune Thrombocytopenia". Clin Med Insights Blood Disord. 9: 15–22. doi:10.4137/CMBD.S39643. PMC 4948655. PMID 27441004.

[pmid27454074-18] Chiarchiaro J, Chen BB, Gibson KF (2016). "New molecular targets for the treatment of sarcoidosis". Curr Opin Pulm Med. 22 (5): 515–21. doi:10.1097/MCP.0000000000000304. PMC 5152532. PMID 27454074.

[pmid12491204-19] Murdoch DR (January 2003). "Diagnosis of Legionella infection". Clin. Infect. Dis. 36 (1): 64–9. doi:10.1086/345529. PMID 12491204.

[Tsokos2011-20] Tsokos, George C. (2011). "Systemic Lupus Erythematosus". New England Journal of Medicine. 365 (22): 2110–2121. doi:10.1056/NEJMra1100359. ISSN 0028-4793.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{CMG}}; {{AE}} {{EG}}
 <span style="font-size:85%">'''Abbreviations:'''
 ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
+<small><small>
 {| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
 ! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
@@ Line 35: / Line 37: @@
 ! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
 |-
-! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
+! rowspan="20" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
 ! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[ANCA-associated vasculitis]]
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Microscopic polyangiitis]]<ref name="pmid20688249">{{cite journal| author=Chung SA, Seo P| title=Microscopic polyangiitis. | journal=Rheum Dis Clin North Am | year= 2010 | volume= 36 | issue= 3 | pages= 545-58 | pmid=20688249 | doi=10.1016/j.rdc.2010.04.003 | pmc=2917831 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20688249  }}</ref>
@@ Line 128: / Line 130: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sinusitis]], [[Hemoptysis]]
 |-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
+! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Goodpasture disease|Anti-glomerular basement membrane disease]]<ref name="pmid28515156">{{cite journal |vauthors=McAdoo SP, Pusey CD |title=Anti-Glomerular Basement Membrane Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=7 |pages=1162–1172 |date=July 2017 |pmid=28515156 |doi=10.2215/CJN.01380217 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypochromic anemia|Hypochromic microcytic anemia]], [[Thrombocytopenia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C3 (complement)|C3]] level
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary hemorrhage]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal [[kidneys]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Alveolar]] infiltrates spreading from the [[hilum]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cellular crescents in the [[glomeruli]], [[Pulmonary hemorrhage|Intra-alveolar hemorrhages]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cryoglobulinemia|Cryoglobulinemic vasculitis]]<ref name="pmid16344620">{{cite journal |vauthors=Ferri C, Mascia MT |title=Cryoglobulinemic vasculitis |journal=Curr Opin Rheumatol |volume=18 |issue=1 |pages=54–63 |date=January 2006 |pmid=16344620 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C4A|C4 component]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[hypocomplementemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O underlying [[malignancy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bacterial endocarditis]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interstitial]] involvement or [[pleural effusions]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HCV]]-associated [[proteins]] in [[vasculitic]] [[skin]], Intraluminal [[cryoglobulin]] deposits
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrocyanosis]], [[Retinal]] [[hemorrhage]], [[Purpura]]
-|-
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]<ref name="pmid28810602">{{cite journal| author=Guo QY, Wu M, Wang YW, Sun GD| title=Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. | journal=Exp Ther Med | year= 2017 | volume= 14 | issue= 2 | pages= 1395-1398 | pmid=28810602 | doi=10.3892/etm.2017.4671 | pmc=5525644 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28810602  }}</ref>
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
@@ Line 191: / Line 151: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Histopathology|Histological confirmation]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Palpable [[purpura]], [[Microscopic hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]<ref name="pmid26990342">{{cite journal |vauthors=Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK |title=IgA vasculitis (Henoch-Schönlein purpura) |journal=Dermatol. Online J. |volume=21 |issue=12 |pages= |date=December 2015 |pmid=26990342 |doi= |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], [[Leukocytosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occult blood|Stool OB]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[bowel]] wall thickness, [[Hematoma|hematomas]], [[peritoneal fluid]], and [[intussusception]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated loops of [[bowel]] consistent in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytoclastic vasculitis]] in postcapillary [[venules]] with [[IgA]] deposition
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Purpura|Palpable purpura]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]<ref name="pmid22328958">{{cite journal| author=Buck A, Christensen J, McCarty M| title=Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. | journal=J Clin Aesthet Dermatol | year= 2012 | volume= 5 | issue= 1 | pages= 36-46 | pmid=22328958 | doi= | pmc=3277093 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22328958  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C11orf1|C1q]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], ↓[[C10orf10|C1q]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Deposits of [[immunoglobulins]], [[complement]], or [[fibrin]] around [[blood vessels]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]],
-[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]], [[Hematuria]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute mesenteric ischemia]]<ref name="pmid24267504">{{cite journal |vauthors=Sise MJ |title=Acute mesenteric ischemia |journal=Surg. Clin. North Am. |volume=94 |issue=1 |pages=165–81 |date=February 2014 |pmid=24267504 |doi=10.1016/j.suc.2013.10.012 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FABP1|I-FABP]], [[GSTA1|Alpha-GST]], [[Ischemia-modified albumin (IMA)]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], ↑[[Hematocrit|HCT]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" | ↑[[Amylase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bowel]] wall thickening, [[Pneumatosis intestinalis|Intestinal pneumatosis]], [[Mesenteric ischemia|Portomesenteric]] thrombosis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric vein thrombosis|Mesenteric venous thrombosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Artery|Arterial]] [[stenosis]] or occlusion of the [[Celiac artery|celiac]] or [[superior mesenteric arteries]] in [[duplex ultrasound]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ileus]] with distended loops of [[bowel]], [[Bowel]] wall thickening in [[abdominal X-ray]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Superficial [[Mucosal bleeding|mucosal hemorrhage]], [[edema]] and [[necrosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Abdominal pain]], [[Distension]], [[Absent bowel sounds]]
 |-
 ! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular diseases|Cardiovascular disease]]
@@ Line 301: / Line 195: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Palpable purpura]], [[Petechiae]]
 |-
-! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
+! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Langerhans Cell Histiocytosis]]<ref name="pmid18572052">{{cite journal |vauthors=Margo CE, Goldman DR |title=Langerhans cell histiocytosis |journal=Surv Ophthalmol |volume=53 |issue=4 |pages=332–58 |date=2008 |pmid=18572052 |doi=10.1016/j.survophthal.2008.04.007 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD1a]], CD207,[[BRAF (gene)|BRAF-V600E]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary cystic lymphangiectasis|Pulmonary cysts]] and [[Pulmonary nodule|nodules]], [[Lytic|Bone lytic lesions]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebellum]] and [[pons]] hyperintensity in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birbeck granules]] by [[electron microscopy]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Brown to purplish [[papules]], [[Eczematous Scaling|Eczematous rash]]
-|-
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non small cell lung cancer|Non-Small Cell Lung Cancer]]<ref name="pmid18452692">{{cite journal| author=Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA| title=Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 5 | pages= 584-94 | pmid=18452692 | doi=10.4065/83.5.584 | pmc=2718421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18452692  }}</ref>
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
@@ Line 363: / Line 236: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spindled cells with dark [[nuclei]], scant [[cytoplasm]], and fine, granular [[Chromatin|nuclear chromatin]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary Infarction]]<ref name="pmid15821192">{{cite journal |vauthors=Parambil JG, Savci CD, Tazelaar HD, Ryu JH |title=Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy |journal=Chest |volume=127 |issue=4 |pages=1178–83 |date=April 2005 |pmid=15821192 |doi=10.1378/chest.127.4.1178 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[D-dimer]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[leukocytosis]], Mild [[anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypoxemia]], [[Hypocarbia]] or [[Hypercarbia]],  [[Respiratory alkalosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary embolism]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-[[density]] filling defect within the [[pulmonary artery]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] infiltrates, [[atelectasis]], and [[pleural effusions]] in [[Chest X-ray|CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarct]] induced [[apoptosis]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary artery]] [[angiography]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
 |-
@@ Line 408: / Line 260: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]]
 |-
-! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
+! rowspan="7" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]<ref name="pmid11691946">{{cite journal |vauthors=Corrigan JJ, Boineau FG |title=Hemolytic-uremic syndrome |journal=Pediatr Rev |volume=22 |issue=11 |pages=365–9 |date=November 2001 |pmid=11691946 |doi= |url=}}</ref>
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
@@ Line 471: / Line 323: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Protein electrophoresis]] plus conventional [[X-rays]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Constipation]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]<ref name="pmid19630574">{{cite journal |vauthors=Klion A |title=Hypereosinophilic syndrome: current approach to diagnosis and treatment |journal=Annu. Rev. Med. |volume=60 |issue= |pages=293–306 |date=2009 |pmid=19630574 |doi=10.1146/annurev.med.60.062107.090340 |url=}}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgE]], [[CD117]] with [[CD2]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[tryptase]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphadenopathy]] and [[splenomegaly]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracardiac thrombus|Intracardiac thrombi]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Reticulin|Reticulin stain]] for [[myelofibrosis]] and [[tryptase]] staining for [[mast cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splinter hemorrhages]], [[Raynaud phenomenon]]
 |-
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
@@ Line 577: / Line 408: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Purpura]]
 |-
-! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
+! rowspan="3" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
 ! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sarcoidosis]]<ref name="pmid27454074">{{cite journal| author=Chiarchiaro J, Chen BB, Gibson KF| title=New molecular targets for the treatment of sarcoidosis. | journal=Curr Opin Pulm Med | year= 2016 | volume= 22 | issue= 5 | pages= 515-21 | pmid=27454074 | doi=10.1097/MCP.0000000000000304 | pmc=5152532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27454074  }}</ref>
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
@@ Line 641: / Line 472: @@
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-dsDNA antibody|Anti-dsDNA antibody test]]
 ! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Skin rashes]] or [[photosensitivity]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[RF]], [[Anti-citrullinated protein antibody|Anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]],
-↑[[ALT]] or [[AST]], [[ANA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fractures|Microfractures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Joint (anatomy)|Effusions in joints]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Basilar invagination with [[cranial]] migration of an eroded [[Odontoid process|odontoid]] peg in [[MRI]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Influx of [[inflammatory cells]] into the [[synovial membrane]], with  [[angiogenesis]], proliferation of chronic [[inflammatory cells]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
-|-
-! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Relapsing polychondritis]]<ref name="pmid27708954">{{cite journal| author=Emmungil H, Aydın SZ| title=Relapsing polychondritis. | journal=Eur J Rheumatol | year= 2015 | volume= 2 | issue= 4 | pages= 155-159 | pmid=27708954 | doi=10.5152/eurjrheum.2015.0036 | pmc=5047229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27708954  }}</ref>
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cryoglobulins]], [[ANA]], [[C-ANCA]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calcification]] of [[Cartilaginous|cartilaginous structures]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]] and degree of [[aortic regurgitation]] in [[echocardiography]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheal stenosis]] in [[CXR]]
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chondrolysis, [[Chondritis]],  Perichondritis
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with imaging
-! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ear pain]] and redness, [[Polyarthritis]]
 |-
 |}
+</small></small>
 ==References==
 {{Reflist|2}}

Small-sized vessel vasculitis with focal neurological sign: Difference between revisions

Revision as of 15:36, 10 April 2018

References

Navigation menu