Lymphocytosis
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| Lymphocytosis Classification and external resources | |
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| Lymphocytosis: Viral meningitis | |
| ICD-10 | D72.8 |
| ICD-9 | 288.8 |
| DiseasesDB | 7678 |
| MeSH | D008218 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
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Overview
Lymphocytosis is an increase in the number or proportion of lymphocytes in the blood, usually detected when a complete blood count is routinely obtained. Lymphocytes normally represent 20 to 40% of circulating white blood cells. The absolute lymphocyte count (ALC) can be directly measured by flow cytometry, or calculated by multiplying the total white blood cell (WBC) count by the percentage of lymphocytes found in the differential count. For example, if the total WBC count is 30,000, and the %lymphocytes is 30, the absolute lymphocyte count is 3,000. In absolute lymphocytosis, the total lymphocyte count is elevated. In relative lymphocytosis, there is a higher proportion of lymphocytes among the white blood cells, but a normal absolute number of lymphocytes. In adults, absolute lymphocytosis is present when the absolute lymphocyte count is greater than 4000 per microliter, while relative lymphocytosis is present if the ALC is normal but the differential percentage of lymphocytes is higher than 40%. Relative lymphocytosis is normal in children under age 2.
Lymphocytosis can be a feature of infection, particularly in children. In the elderly, lymphoproliferative disorders, including chronic lymphocytic leukemia and lymphomas, often present with lymphadenopathy and a lymphocytosis.
Differential diagnosis of causes of lymphocytosis
Causes of absolute lymphocytosis include: acute viral infections, such as infectious mononucleosis (glandular fever), Epstein-Barr virus infection, and hepatitis; other acute infections such as pertussis and toxoplasmosis; chronic intracellular bacterial infections such as tuberculosis or brucellosis.
Causes of relative lymphocytosis include: age less than 2 years; acute viral infections; connective tissue diseases, thyrotoxicosis, Addison's disease, and splenomegaly with splenic sequestration of granulocytes.
In alphabetical order. [1] [2]
- Acute infection
- Addison's Disease
- Adenovirus
- Brucellosis
- Chickenpox
- Chronic and acute lymphocytic leukemia
- Chronic erythroleukemia
- Chronic myelogenous leukemia
- Cytomegalovirus
- Drug hypersensitivity
- Exertion
- Hairy Cell Leukemia
- Hepatitis viruses
- Herpes virus
- HIV
- Hyperthyroidism
- Immunocytoma
- Infectious mononucleosis
- Inflammatory Bowel Disease
- Measles
- Mumps
- Osteomyelofibrosis
- Pain
- Pertussis
- Polycythemia
- Postoperative
- Sarcoidosis
- Stress
- Syphilis
- Toxoplasmosis
- Trauma
- Tuberculosis
- Varicella
- Viral pneumonia
- Waldenstrom's Syndrome
References
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
Acknowledgements
The content on this page was first contributed by Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3] Phone:617-632-7753
List of contributors:
For Patients
WikiDoc Research Resources for Lymphocytosis | |
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| Articles on Lymphocytosis | Most recent articles on Lymphocytosis • Most cited articles on Lymphocytosis • Review articles on Lymphocytosis • Articles on Lymphocytosis in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Lymphocytosis | Powerpoint slides on Lymphocytosis • Images of Lymphocytosis • Photos of Lymphocytosis • Podcasts & MP3s on Lymphocytosis • Videos on Lymphocytosis |
| Evidence Based Medicine Regarding Lymphocytosis | Cochrane Collaboration on Lymphocytosis • Bandolier on Lymphocytosis • TRIP on Lymphocytosis |
| Cost Effectiveness of Lymphocytosis | Cost Effectiveness of Lymphocytosis |
| Clinical Trials Involving Lymphocytosis | Ongoing Trials on Lymphocytosis at Clinical Trials.gov • Trial results on Lymphocytosis • Clinical Trials on Lymphocytosis at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Lymphocytosis | US National Guidelines Clearinghouse on Lymphocytosis • NICE Guidance on Lymphocytosis • NHS PRODIGY Guidance • FDA on Lymphocytosis • CDC on Lymphocytosis |
| Textbook Information on Lymphocytosis | Books and Textbook Information on Lymphocytosis |
| Pharmacology Resources on Lymphocytosis | Dosing of Lymphocytosis • Drug interactions with Lymphocytosis • Side effects of Lymphocytosis • Allergic reactions to Lymphocytosis • Overdose information on Lymphocytosis • Carcinogenicity information on Lymphocytosis • Lymphocytosis in pregnancy • Pharmacokinetics of Lymphocytosis • |
| Genetics, Pharmacogenomics, and Proteinomics of Lymphocytosis | Genetics of Lymphocytosis • Pharmacogenomics of Lymphocytosis • Proteomics of Lymphocytosis |
| Newstories on Lymphocytosis | Lymphocytosis in the news • Be alerted to news on Lymphocytosis • News trends on Lymphocytosis |
| Commentary on Lymphocytosis | Blogs on Lymphocytosis |
| Patient Resources on Lymphocytosis | Patient resources on Lymphocytosis • Discussion groups on Lymphocytosis • Patient Handouts on Lymphocytosis • Directions to Hospitals Treating Lymphocytosis • Risk calculators and risk factors for Lymphocytosis |
| Healthcare Provider Resources on Lymphocytosis | Symptoms of Lymphocytosis • Causes & Risk Factors for Lymphocytosis • Diagnostic studies for Lymphocytosis • Treatment of Lymphocytosis |
| Continuing Medical Education (CME) Programs on Lymphocytosis | CME Programs on Lymphocytosis |
| International Resources on Lymphocytosis | Lymphocytosis en Espanol • Lymphocytosis en Francais |
| Business Resources on Lymphocytosis | Lymphocytosis in the Marketplace • Patents on Lymphocytosis |
| Informatics Resources on Lymphocytosis | List of terms related to Lymphocytosis |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
