List of chemotherapeutic agents: Difference between revisions

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Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles.  
Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles.  


== Alkylating agents ==
==Chemotherapeutic Agents by Category==
{{Main|Alkylating agent}}
===Cytotoxic Chemotherapy===
'''Bifunctional Alkylators'''
===== Alkylating agents =====
* [[Cyclophosphamide]]
===== Anthracyclines =====
* [[Mechlorethamine]]
===== Antimetabolites =====
* [[Chlorambucil]]
===== DNA synthesis inhibitors =====
* [[Melphalan]]
===== Microtubule inhibitors =====
 
===== Nitrogen mustards =====
'''Monofunctional Alkylators'''
===== Nitrosureas =====
* [[Nitrosourea]]
===== Platinum agents =====
* [[Temozolomide]]
===== Proteasome inhibitors =====
 
===== Taxanes =====
== Anthracyclines ==
===== Topoisomerase inhibitors =====
{{Main|anthracycline}}
===== Vinca alkaloids =====
* [[Daunorubicin]]
----
* [[Doxorubicin]]
=== Kinase inhibitors ===
* [[Epirubicin]]
----
* [[Idarubicin]]
=== HDAC inhibitors ===
* [[Mitoxantrone]]
----
* [[Valrubicin]]
=== Endocrine therapy ===
 
===== Antiandrogens =====
== Cytoskeletal disruptors (Taxanes) ==
===== Steroid synthesis inhibitors =====
{{Main|Taxane}}
===== Androgen receptor inhibitors =====
* [[Paclitaxel]]
===== 5α-reductase inhibitors =====
* [[Docetaxel]]
===== GnRH agonists =====
 
===== GnRH antagonists =====
== Epothilones ==
===== Aromatase inhibitors =====
{{Main|epothilone}}
===== Selective estrogen receptor modulators =====
 
----
== Histone Deacetylase Inhibitors ==
=== Biologics ===
* [[Vorinostat]]
===== Antibody medications =====
* [[Romidepsin]]
===== Antibody-drug conjugates =====
 
===== Anti-HER2 medications =====
== Inhibitors of Topoisomerase I ==
===== IL-6 inhibitors =====
{{Main|Topoisomerase inhibitor}}
===== Enzymes =====
* [[Irinotecan]]
===== Immunotherapy =====
* [[Topotecan]]
===== Immunomodulatory drugs (IMiDs) =====
 
* [[Lenalidomide|Lenalidomide (Revlimid)]]
== Inhibitors of Topoisomerase II ==
* [[Pomalidomide|Pomalidomide (Pomalyst)]]
{{Main|Topoisomerase II inhibitor}}
----
* [[Etoposide]]
=== Hematopoietic Growth Factors ===
* [[Teniposide]]
===== Erythrocyte growth factors =====
* [[Tafluposide]]
===== Granulocyte growth factors =====
 
===== Megakaryocyte growth factors =====
== Kinase inhibitors ==
----
{{Main|Kinase inhibitor}}
=== Supportive Medications ===
* [[Bortezomib]]
===== Chemotherapy protective agents =====
* [[Erlotinib]]
===== Antiemetic agents =====
* [[Gefitinib]]
===== RANK ligand inhibitors =====
* [[Imatinib]]
----
* [[Vemurafenib]]
=== Miscellaneous ===
* [[Vismodegib]]
===== Immunosuppresants =====
 
===== Radioimmunotherapy =====
== Nucleotide analogs and precursor analogs ==
===== Retinoids =====
* [[Azacitidine]]
----
* [[Azathioprine]]
== Chemotherapeutic Agents in Alphabetical Order ==
* [[Capecitabine]]
* [[Cytarabine]]
* [[Doxifluridine]]
* [[Fluorouracil]]
* [[Gemcitabine]]
* [[Hydroxyurea]]
* [[Mercaptopurine]]
* [[Methotrexate]]
* [[Tioguanine]] (formerly Thioguanine)
 
== Peptide antibiotics ==
* [[Bleomycin]]
* [[Actinomycin]]
 
== Platinum-based agents ==
{{Main|Platinum-based antineoplastic}}
* [[Carboplatin]]
* [[Cisplatin]]
* [[Oxaliplatin]]
 
== Retinoids ==
* [[Tretinoin]]
* [[Alitretinoin]]
* [[Bexarotene]]
 
== Vinca alkaloids and derivatives ==
{{Main|Vinca alkaloid}}
* [[Vinblastine]]
* [[Vincristine]]
* [[Vindesine]]
* [[Vinorelbine]]
 
==Chemotherapeutic Agents in Alphabetical Order==
* [[Abiraterone|Abiraterone acetate (Zytiga)]]
* [[Abiraterone|Abiraterone acetate (Zytiga)]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]

Revision as of 11:12, 3 February 2015

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Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Overview

This is a list of chemotherapeutic agents (also known as cytotoxic agents) that are known to be of use in chemotherapy for cancer. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy). For example, the CHOP regimen consists of cyclophosphamide, hydroxydaunorubicin (doxorubicin), vincristine (Oncovin), and prednisone.

Besides chemotherapy, medical oncology (pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant articles.

Chemotherapeutic Agents by Category

Cytotoxic Chemotherapy

Alkylating agents
Anthracyclines
Antimetabolites
DNA synthesis inhibitors
Microtubule inhibitors
Nitrogen mustards
Nitrosureas
Platinum agents
Proteasome inhibitors
Taxanes
Topoisomerase inhibitors
Vinca alkaloids

Kinase inhibitors


HDAC inhibitors


Endocrine therapy

Antiandrogens
Steroid synthesis inhibitors
Androgen receptor inhibitors
5α-reductase inhibitors
GnRH agonists
GnRH antagonists
Aromatase inhibitors
Selective estrogen receptor modulators

Biologics

Antibody medications
Antibody-drug conjugates
Anti-HER2 medications
IL-6 inhibitors
Enzymes
Immunotherapy
Immunomodulatory drugs (IMiDs)

Hematopoietic Growth Factors

Erythrocyte growth factors
Granulocyte growth factors
Megakaryocyte growth factors

Supportive Medications

Chemotherapy protective agents
Antiemetic agents
RANK ligand inhibitors

Miscellaneous

Immunosuppresants
Radioimmunotherapy
Retinoids

Chemotherapeutic Agents in Alphabetical Order