IL18R1: Difference between revisions

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{{Infobox_gene}}
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The '''interleukin-18 receptor 1''' (IL-18R1) is an [[interleukin receptor]] of the [[immunoglobulin superfamily]]. '''IL18R1''' is its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809| accessdate = }}</ref> IL18R1 is also known as '''CDw218a''' ([[cluster of differentiation]] w218a).
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Interleukin 18 receptor 1
| HGNCid = 5988
| Symbol = IL18R1
| AltSymbols =; CDw218a; IL-1Rrp; IL1RRP
| OMIM = 604494
| ECnumber = 
| Homologene = 2861
| MGIid = 105383
| GeneAtlas_image1 = PBB_GE_IL18R1_206618_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0004908 |text = interleukin-1 receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8809
    | Hs_Ensembl = ENSG00000115604
    | Hs_RefseqProtein = NP_003846
    | Hs_RefseqmRNA = NM_003855
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 102345529
    | Hs_GenLoc_end = 102381650
    | Hs_Uniprot = Q13478
    | Mm_EntrezGene = 16182
    | Mm_Ensembl = ENSMUSG00000026070
    | Mm_RefseqmRNA = NM_008365
    | Mm_RefseqProtein = NP_032391
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 40410552
    | Mm_GenLoc_end = 40445379
    | Mm_Uniprot = Q8C257
  }}
}}
The '''interleukin-18 receptor 1''' (IL-18R1) is an [[interleukin receptor]] of the [[immunoglobulin superfamily]]. '''IL18R1''' is its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809| accessdate = }}</ref> IL18R1 is also known as '''CDw218a''' ([[cluster of differentiation]] w218a).


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.<ref name="entrez">{{cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sergi B, Penttila I |title=Interleukin 18 receptor. |journal=J. Biol. Regul. Homeost. Agents |volume=18 |issue= 1 |pages= 55-61 |year= 2005 |pmid= 15323361 |doi=  }}
*{{cite journal  |vauthors=Sergi B, Penttila I |title=Interleukin 18 receptor |journal=J. Biol. Regul. Homeost. Agents |volume=18 |issue= 1 |pages= 55–61 |year= 2005 |pmid= 15323361 |doi=  }}
*{{cite journal  | author=Parnet P, Garka KE, Bonnert TP, ''et al.'' |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967-70 |year= 1996 |pmid= 8626725 |doi=  }}
*{{cite journal  | author=Parnet P |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967–70 |year= 1996 |pmid= 8626725 |doi=10.1074/jbc.271.8.3967 |name-list-format=vanc| author2=Garka KE | author3=Bonnert TP  | display-authors=3  | last4=Dower  | first4=SK  | last5=Sims  | first5=JE }}
*{{cite journal | author=Lovenberg TW, Crowe PD, Liu C, ''et al.'' |title=Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). |journal=J. Neuroimmunol. |volume=70 |issue= 2 |pages= 113-22 |year= 1996 |pmid= 8898719 |doi=  }}
*{{cite journal  | author=Lovenberg TW |title=Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2) |journal=J. Neuroimmunol. |volume=70 |issue= 2 |pages= 113–22 |year= 1996 |pmid= 8898719 |doi=10.1016/S0165-5728(96)00047-1 |name-list-format=vanc| author2=Crowe PD  | author3=Liu C  | display-authors=3  | last4=Chalmers  | first4=Derek T. | last5=Liu  | first5=Xin-Jun  | last6=Liaw  | first6=Chen  | last7=Clevenger  | first7=William  | last8=Oltersdorf | first8=Tilman  | last9=De Souza  | first9=Errol B. }}
*{{cite journal  | author=Torigoe K, Ushio S, Okura T, ''et al.'' |title=Purification and characterization of the human interleukin-18 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25737-42 |year= 1997 |pmid= 9325300 |doi= }}
*{{cite journal  | author=Torigoe K |title=Purification and characterization of the human interleukin-18 receptor |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25737–42 |year= 1997 |pmid= 9325300 |doi=10.1074/jbc.272.41.25737 |name-list-format=vanc| author2=Ushio S | author3=Okura T  | display-authors=3  | last4=Kobayashi  | first4=S  | last5=Taniai  | first5=M  | last6=Kunikata  | first6=T  | last7=Murakami  | first7=T  | last8=Sanou  | first8=O  | last9=Kojima  | first9=H }}
*{{cite journal | author=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. |journal=Genomics |volume=57 |issue= 1 |pages= 177-9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767 }}
*{{cite journal  |vauthors=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767 }}
*{{cite journal | author=Hoshino K, Tsutsui H, Kawai T, ''et al.'' |title=Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5041-4 |year= 1999 |pmid= 10227969 |doi= }}
*{{cite journal  | author=Hoshino K |title=Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5041–4 |year= 1999 |pmid= 10227969 |doi=  |name-list-format=vanc| author2=Tsutsui H  | author3=Kawai T  | display-authors=3  | last4=Takeda  | first4=K  | last5=Nakanishi  | first5=K  | last6=Takeda  | first6=Y  | last7=Akira  | first7=S }}
*{{cite journal | author=Sareneva T, Julkunen I, Matikainen S |title=IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. |journal=J. Immunol. |volume=165 |issue= 4 |pages= 1933-8 |year= 2000 |pmid= 10925275 |doi=  }}
*{{cite journal  |vauthors=Sareneva T, Julkunen I, Matikainen S |title=IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells |journal=J. Immunol. |volume=165 |issue= 4 |pages= 1933–8 |year= 2000 |pmid= 10925275 |doi=  10.4049/jimmunol.165.4.1933}}
*{{cite journal  | author=Kumar S, Hanning CR, Brigham-Burke MR, ''et al.'' |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production. |journal=Cytokine |volume=18 |issue= 2 |pages= 61-71 |year= 2003 |pmid= 12096920 |doi= }}
*{{cite journal  | author=Kumar S |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production |journal=Cytokine |volume=18 |issue= 2 |pages= 61–71 |year= 2003 |pmid= 12096920 |doi=10.1006/cyto.2002.0873 |name-list-format=vanc| author2=Hanning CR  | author3=Brigham-Burke MR  | display-authors=3  | last4=Rieman  | first4=David J. | last5=Lehr  | first5=Ruth  | last6=Khandekar  | first6=Sanjay  | last7=Kirkpatrick  | first7=Robert B.  | last8=Scott  | first8=Gilbert F.  | last9=Lee  | first9=John C. }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler | first9=GD }}
*{{cite journal | author=Gutzmer R, Langer K, Mommert S, ''et al.'' |title=Human dendritic cells express the IL-18R and are chemoattracted to IL-18. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6363-71 |year= 2004 |pmid= 14662834 |doi=  }}
*{{cite journal  | author=Gutzmer R |title=Human dendritic cells express the IL-18R and are chemoattracted to IL-18 |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6363–71 |year= 2004 |pmid= 14662834 |doi= 10.4049/jimmunol.171.12.6363|name-list-format=vanc| author2=Langer K | author3=Mommert S  | display-authors=3  | last4=Wittmann  | first4=M  | last5=Kapp  | first5=A  | last6=Werfel  | first6=T  }}
*{{cite journal  | author=Azam T, Novick D, Bufler P, ''et al.'' |title=Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6574-80 |year= 2004 |pmid= 14662859 |doi=  }}
*{{cite journal  | author=Azam T |title=Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6574–80 |year= 2004 |pmid= 14662859 |doi= 10.4049/jimmunol.171.12.6574|name-list-format=vanc| author2=Novick D | author3=Bufler P  | display-authors=3  | last4=Yoon  | first4=DY  | last5=Rubinstein  | first5=M  | last6=Dinarello  | first6=CA  | last7=Kim  | first7=SH  }}
*{{cite journal  | author=Towne JE, Garka KE, Renshaw BR, ''et al.'' |title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13677-88 |year= 2004 |pmid= 14734551 |doi= 10.1074/jbc.M400117200 }}
*{{cite journal  | author=Towne JE |title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13677–88 |year= 2004 |pmid= 14734551 |doi= 10.1074/jbc.M400117200  |name-list-format=vanc| author2=Garka KE  | author3=Renshaw BR  | display-authors=3  | last4=Virca  | first4=GD  | last5=Sims  | first5=JE }}
*{{cite journal | author=Cardoso SP, Keen L, Bidwell J |title=Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha. |journal=Eur. J. Immunogenet. |volume=31 |issue= 1 |pages= 27-9 |year= 2004 |pmid= 15009178 |doi=  }}
*{{cite journal  |vauthors=Cardoso SP, Keen L, Bidwell J |title=Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha |journal=Eur. J. Immunogenet. |volume=31 |issue= 1 |pages= 27–9 |year= 2004 |pmid= 15009178 |doi=10.1111/j.1365-2370.2004.00441.x  }}
*{{cite journal  | author=Reddy SA, Lin YF, Huang HJ, ''et al.'' |title=The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 4 |pages= 1022-8 |year= 2004 |pmid= 15044087 |doi= 10.1016/j.bbrc.2004.02.155 }}
*{{cite journal  | author=Reddy SA |title=The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 4 |pages= 1022–8 |year= 2004 |pmid= 15044087 |doi= 10.1016/j.bbrc.2004.02.155  |name-list-format=vanc| author2=Lin YF  | author3=Huang HJ  | display-authors=3  | last4=Samanta  | first4=Ajoy K  | last5=Liao  | first5=Warren S.-L }}
*{{cite journal | author=Yoon- DY, Cho YS, Park JW, ''et al.'' |title=Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor. |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 5 |pages= 499-506 |year= 2005 |pmid= 15202785 |doi=  }}
*{{cite journal  | author=Yoon- DY |title=Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 5 |pages= 499–506 |year= 2005 |pmid= 15202785 |doi=10.1515/CCLM.2004.085  |name-list-format=vanc| author2=Cho YS  | author3=Park JW  | display-authors=3  | last4=Kim  | first4=Soo-Hyun  | last5=Kim  | first5=Jong-Wan  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Fukushima K, Ikehara Y, Yamashita K |title=Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production. |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18056-62 |year= 2005 |pmid= 15760905 |doi= 10.1074/jbc.M413297200 }}
*{{cite journal  |vauthors=Fukushima K, Ikehara Y, Yamashita K |title=Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18056–62 |year= 2005 |pmid= 15760905 |doi= 10.1074/jbc.M413297200 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | author=Hillier LW |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466  |name-list-format=vanc| author2=Graves TA  | author3=Fulton RS  | display-authors=3  | last4=Fulton  | first4=Lucinda A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Minx  | first6=Patrick  | last7=Wagner-Mcpherson  | first7=Caryn  | last8=Layman  | first8=Dan  | last9=Wylie  | first9=Kristine }}
*{{cite journal | author=Sahar S, Dwarakanath RS, Reddy MA, ''et al.'' |title=Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis. |journal=Circ. Res. |volume=96 |issue= 10 |pages= 1064-71 |year= 2005 |pmid= 15860756 |doi= 10.1161/01.RES.0000168210.10358.f4 }}
*{{cite journal  | author=Sahar S |title=Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis |journal=Circ. Res. |volume=96 |issue= 10 |pages= 1064–71 |year= 2005 |pmid= 15860756 |doi= 10.1161/01.RES.0000168210.10358.f4 |name-list-format=vanc| author2=Dwarakanath RS  | author3=Reddy MA  | display-authors=3  | last4=Lanting  | first4=L  | last5=Todorov  | first5=I  | last6=Natarajan  | first6=R }}
}}
}}
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* {{MeshName|IL18R1+protein,+human}}
* {{MeshName|IL18R1+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Immune receptors}}
{{Immune receptors}}
{{Cytokine receptors}}
{{Interleukin receptor modulators}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
[[Category:Cytokine receptors]]
[[Category:Immunoglobulin superfamily cytokine receptors]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 23:47, 31 August 2017

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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Wikidata
View/Edit Human

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[1] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: IL18R1 interleukin 18 receptor 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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