L1 (protein)
| L1 cell adhesion molecule
| |
| Identifiers | |
| Symbol | L1CAM |
| Alt. Symbols | HSAS1, SPG1, HSAS, MASA, MIC5, S10 |
| Entrez | 3897 |
| HUGO | 6470 |
| OMIM | 308840 |
| RefSeq | NM_024003 |
| UniProt | P32004 |
| Other data | |
| Locus | Chr. X q28 |
L1 is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family. 200-220 kDa. Involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers.
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Membrane proteins: cell adhesion molecules | |
|---|---|
| IgSF | N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM |
| Cadherins | Desmoglein - T-cadherin |
| Selectins | E-selectin - L-selectin - P-selectin |
| Integrins | LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs) |
| Other | Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164 |
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