CNTN2

Contactin 2 (axonal)
Identifiers
Symbols	CNTN2 ; AXT; DKFZp781D102; FLJ42746; MGC157722; TAG-1; TAX; TAX1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3720
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Contactin 2 (axonal), also known as CNTN2, is a human gene.

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention.

Further reading

• Walsh FS, Doherty P (1992). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biol. Int. Rep. 15 (11): 1151–66. PMID 1838307.
• Kuhn TB, Stoeckli ET, Condrau MA; et al. (1991). "Neurite outgrowth on immobilized axonin-1 is mediated by a heterophilic interaction with L1(G4)". J. Cell Biol. 115 (4): 1113–26. PMID 1720120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dodd J, Morton SB, Karagogeos D; et al. (1990). "Spatial regulation of axonal glycoprotein expression on subsets of embryonic spinal neurons". Neuron. 1 (2): 105–16. PMID 3272160.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kenwrick S, Leversha M, Rooke L; et al. (1993). "Localization of the human TAX-1 gene to 1q32.1: a region implicated in microcephaly and Van der Woude syndrome". Hum. Mol. Genet. 2 (9): 1461–2. PMID 8242070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsiotra PC, Karagogeos D, Theodorakis K; et al. (1994). "Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1". Genomics. 18 (3): 562–7. PMID 8307567.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rader C, Stoeckli ET, Ziegler U; et al. (1993). "Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1". Eur. J. Biochem. 215 (1): 133–41. PMID 8344273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hasler TH, Rader C, Stoeckli ET; et al. (1993). "cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1". Eur. J. Biochem. 211 (1–2): 329–39. PMID 8425542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kozlov SV, Giger RJ, Hasler T; et al. (1996). "The human TAX1 gene encoding the axon-associated cell adhesion molecule TAG-1/axonin-1: genomic structure and basic promoter". Genomics. 30 (2): 141–8. doi:10.1006/geno.1995.9892. PMID 8586412.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshihara Y, Kawasaki M, Tamada A; et al. (1996). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". J. Neurobiol. 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milev P, Maurel P, Häring M; et al. (1996). "TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM". J. Biol. Chem. 271 (26): 15716–23. PMID 8663515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pise-Masison CA, Dittmer J, Clemens KE, Brady JN (1997). "Physical and functional interaction between the human T-cell lymphotropic virus type 1 Tax1 protein and the CCAAT binding protein NF-Y". Mol. Cell. Biol. 17 (3): 1236–43. PMID 9032250.CS1 maint: Multiple names: authors list (link)
• Williams H, Schachner M, Wang B, Kenwrick S (1998). "Radiation hybrid mapping of the genes for tenascin-R (TNR), phosducin (PDC), laminin C1 (LAMC1), and TAX in 1q25-q32". Genomics. 46 (1): 165–6. doi:10.1006/geno.1997.4994. PMID 9403076.CS1 maint: Multiple names: authors list (link)
• Malhotra JD, Tsiotra P, Karagogeos D, Hortsch M (1999). "Cis-activation of L1-mediated ankyrin recruitment by TAG-1 homophilic cell adhesion". J. Biol. Chem. 273 (50): 33354–9. PMID 9837910.CS1 maint: Multiple names: authors list (link)
• Freigang J, Proba K, Leder L; et al. (2000). "The crystal structure of the ligand binding module of axonin-1/TAG-1 suggests a zipper mechanism for neural cell adhesion". Cell. 101 (4): 425–33. PMID 10830169.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rickman DS, Tyagi R, Zhu XX; et al. (2001). "The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas". Cancer Res. 61 (5): 2162–8. PMID 11280781.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pavlou O, Theodorakis K, Falk J; et al. (2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Mol. Cell. Neurosci. 20 (3): 367–81. PMID 12139915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Traka M, Goutebroze L, Denisenko N; et al. (2003). "Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers". J. Cell Biol. 162 (6): 1161–72. doi:10.1083/jcb.200305078. PMID 12975355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–65. PMID 14697242.