ATP-binding cassette, sub-family G (WHITE), member 2
|RNA expression pattern|
ATP-binding cassette, sub-family G (WHITE), member 2, also known as ABCG2, is a human gene.
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.
- Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism.". J. Lipid Res. 42 (10): 1513–20. PMID 11590207.
- Ejendal KF, Hrycyna CA (2003). "Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.". Curr. Protein Pept. Sci. 3 (5): 503–11. PMID 12369998.
- Doyle LA, Ross DD (2003). "Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).". Oncogene. 22 (47): 7340–58. PMID 14576842. doi:10.1038/sj.onc.1206938.
- Sugimoto Y, Tsukahara S, Ishikawa E, Mitsuhashi J (2005). "Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.". Cancer Sci. 96 (8): 457–65. PMID 16108826. doi:10.1111/j.1349-7006.2005.00081.x.
- Ishikawa T, Tamura A, Saito H; et al. (2006). "Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.". Naturwissenschaften. 92 (10): 451–63. PMID 16160819. doi:10.1007/s00114-005-0019-4.
- Krishnamurthy P, Schuetz JD (2006). "Role of ABCG2/BCRP in biology and medicine.". Annu. Rev. Pharmacol. Toxicol. 46: 381–410. PMID 16402910. doi:10.1146/annurev.pharmtox.46.120604.141238.
- Robey RW, Polgar O, Deeken J; et al. (2007). "ABCG2: determining its relevance in clinical drug resistance.". Cancer Metastasis Rev. 26 (1): 39–57. PMID 17323127. doi:10.1007/s10555-007-9042-6.