Cadherin-16 is a protein that in humans is encoded by the CDH16 gene.[1][2][3]
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.[3]
References
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↑Thomson RB, Igarashi P, Biemesderfer D, Kim R, Abu-Alfa A, Soleimani M, Aronson PS (Aug 1995). "Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific member of the cadherin multigene family". J Biol Chem. 270 (29): 17594–601. doi:10.1074/jbc.270.29.17594. PMID7615566.
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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney". Am. J. Physiol. 277 (1 Pt 2): F146–56. PMID10409308.
Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping". Cytogenet. Cell Genet. 88 (3–4): 253–4. doi:10.1159/000015531. PMID10828602.
Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD". Am. J. Physiol. Renal Physiol. 285 (5): F870–80. doi:10.1152/ajprenal.00153.2003. PMID12851251.
Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin". Exp. Cell Res. 294 (2): 345–55. doi:10.1016/j.yexcr.2003.11.022. PMID15023525.
Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications". Am. J. Surg. Pathol. 31 (10): 1528–33. doi:10.1097/PAS.0b013e318058818c. PMID17895753.
