LFA-1 stands for Lymphocyte function-associated antigen-1.
LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule, it is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.
- Janeway, Travers, Walport, Shlomchik, Immunobiology 6th ed. (2005) Garland Science:NY
- LFA-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA (1981). "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing". Proc. Natl. Acad. Sci. U.S.A. 78 (7): 4535–9. PMID 7027264.