CD97
| CD97 molecule | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 PDB rendering based on 2bo2. | |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | CD97 ; TM7LN1 | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 8050 | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Template:GNF Ortholog box | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | n/a | n/a | |||||||||||
| Ensembl | n/a | n/a | |||||||||||
| UniProt | n/a | n/a | |||||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||||
| RefSeq (protein) | n/a | n/a | |||||||||||
| Location (UCSC) | n/a | n/a | |||||||||||
| PubMed search | n/a | n/a | |||||||||||
CD97 molecule, also known as CD97, is a human gene.[1]
This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.[1]
References
Further reading
- Kwakkenbos MJ, Kop EN, Stacey M; et al. (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics. 55 (10): 655–66. doi:10.1007/s00251-003-0625-2. PMID 14647991.
- Hamann J, Eichler W, Hamann D; et al. (1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain". J. Immunol. 155 (4): 1942–50. PMID 7636245.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Hamann J, Hartmann E, van Lier RA (1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily". Genomics. 32 (1): 144–7. doi:10.1006/geno.1996.0092. PMID 8786105.
- Gray JX, Haino M, Roth MJ; et al. (1997). "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation". J. Immunol. 157 (12): 5438–47. PMID 8955192.
- Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)". J. Exp. Med. 184 (3): 1185–9. PMID 9064337.
- Aust G, Eichler W, Laue S; et al. (1997). "CD97: a dedifferentiation marker in human thyroid carcinomas". Cancer Res. 57 (9): 1798–806. PMID 9135025.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Ghannadan M, Baghestanian M, Wimazal F; et al. (1998). "Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies". J. Invest. Dermatol. 111 (4): 689–95. doi:10.1046/j.1523-1747.1998.00359.x. PMID 9764855.
- Qian YM, Haino M, Kelly K, Song WC (1999). "Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55)". Immunology. 98 (2): 303–11. PMID 10540231.
- Eichler W (2000). "CD97 isoform expression in leukocytes". J. Leukoc. Biol. 68 (4): 561–7. PMID 11037979.
- Lin HH, Stacey M, Saxby C; et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex". J. Biol. Chem. 276 (26): 24160–9. doi:10.1074/jbc.M101770200. PMID 11297558.
- Jaspars LH, Vos W, Aust G; et al. (2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325–31. PMID 11380941.
- Steinert M, Wobus M, Boltze C; et al. (2002). "Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues". Am. J. Pathol. 161 (5): 1657–67. PMID 12414513.
- Visser L, de Vos AF, Hamann J; et al. (2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis". J. Neuroimmunol. 132 (1–2): 156–63. PMID 12417446.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Stacey M, Chang GW, Davies JQ; et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans". Blood. 102 (8): 2916–24. doi:10.1182/blood-2002-11-3540. PMID 12829604.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
| Stub icon | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |
