Troponin I

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Troponin

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]


Overview

Troponin I is a part of the troponin complex. It binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place. The letter I is given due to its inhibitory character.

The tissue specific subtypes are:

  • Slow-twitch skeletal muscle isoform troponin I, TNNI1 (1q31.3, 191042)
  • Fast-twitch skeletal muscle isoform troponin I, TNNI2 (11p15.5, 191043)
  • Cardiac troponin I, TNNI3 (19q13.4, 191044)

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