Stunned myocardium
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Stunned myocardium or myocardial stunning is a state in which a section of the myocardium (corresponding to area of a major coronary occlusion) contracts abnormally despite normal blood flow. Myocardial stunning is a reduction in myocardial contractility reperfusion not accounted for by tissue damage or reduced blood flow. This is a segmental dysfunction which persists for a variable period of time, about two weeks, even after ischemia has been relieved (by angioplasty or coronary artery bypass surgery).
In this situation, while myocardial blood flow (MBF) returns to normal, function is still depressed for a variable period of time.
Stunned myocardium can be observed in the following clinical scenarios:
- Acute myocardial infarction (AMI)
- After percutaneous transluminal coronary angioplasty (PTCA)
- After cardiac surgery
See also
- Hibernating myocardium
- Myocardial scarring
- Myocardial infarction
Additional Readings
Ischemic Heart Disease at the Cellular Level
Additional Resources
- The MD TV: Comments on Hot Topics, State of the Art Presentations in Cardiovascular Medicine, Expert Reviews on Cardiovascular Research
- Clinical Trial Results: A resource of Cardiovascular Research
External links
- "Myocardial “stunning” in man"
- Baker C, Rimoldi O, Camici P, Barnes E, Chacon M, Huehns T, Haskard D, Polak J, Hall R (1999). "Repetitive myocardial stunning in pigs is associated with the increased expression of inducible and constitutive nitric oxide synthases.". Cardiovasc Res 43 (3): 685-97. PMID 10690340.
- Grund F (2001). "Three cardiac mysteries--stunning, hibernation and ischemic preconditioning". Tidsskr Nor Laegeforen 121 (4): 440-4. PMID 11255859.
- MeSH Myocardial+Stunning
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
