Tropomyosin
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Overview
Tropomyosin, along with troponin, regulates the shortening of the muscle protein filaments actin and myosin. In resting muscle fibres, tropomyosin is displaced from its normal binding groove by troponin. This displaced conformation of tropomyosin prevents the binding of myosin heads, thereby inhibiting muscle contraction. Under normal stimulation to muscle fibers, Ca2+ ions are released from the sarcoplasmic reticulum of the myocytes which causes troponin to release its hold on actin, allowing tropomyosin to return to a normal conformation which allows myosin heads to walk along actin filaments and thereby facilitating muscle contraction.
Functional Characteristics
Sliding filament theory
Tropomyosin is an alpha helical coiled coil protein dimer that binds end to end along F actin filaments in striated muscle. Tropomyosin blocks myosin binding and hence crossbridge cycling in the absence of Ca2+ and the muscle Ca2+ regulatory element troponin. Ca2+ influx from the sarcoplasmic reticulum of striated muscle myocytes binds to troponin and subsequently moves tropomyosin on the F-actin filament exposing the myosin binding sites.
Recent structural visualization and kinetic modeling has suggested that myosin binding further moves tropomyosin on actin to a fully open state allowing for uninhibited crossbridge cycling as the muscle contracts. This three state model of thin filament regulation involving tropomyosin and troponin is still debated by experts who believe that two state regulation of muscle contraction (involving a blocked and open state) is sufficient to explain current experimental data and models.
Allergies
Tropomyosin is a pan-allergen (an allergen widely-distributed in the nature) because it is a highly-conserved protein among species. Certain tropomyosins are known to cause allergies in certain people, and those who have cross-reactive allergies can get symptons from a range of sources due to a common allergen found in all these sources: Shrimp, dust mites and mollusks. This common allergen is the reason why some people sensitized with mite tropomyosin could have an allergic reaction after eating seafood.
Genes
Additional images
 Molecular mechanisms of muscular function |
External links
Proteins of the cytoskeleton | |
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| Microfilaments | Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein |
| Intermediate filaments | type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament, Synemin, Syncoilin) - type 5 (Lamin A, B) |
| Microtubules | Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin - Tektin |
| Catenins | Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin |
| Nonhuman | Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB) |
| Other | APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
