Adrenocortical carcinoma natural history
Adrenocortical carcinoma Microchapters
Natural History, Complications and Prognosis
Adrenocortical carcinoma natural history On the Web
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The following are the complications of Adrenocortical carcinoma:
- Cushing's syndrome
- Conn syndrome
- Local metastasis and tumor thrombus formation
- Paraneoplastic syndrome
- Distant metastasis
ACC, generally, carries a poor prognosis and is unlike most tumours of the adrenal cortex, which are benign (adenomas) and only occasionally cause Cushing's syndrome. Five-year disease-free survival for a complete resection of a stage I-III ACC is approximately 30%. The most important prognostic factors are:
- Age of the patient.
- Stage of the tumor.
Poor prognostic factors:
- Mitotic activity.
- Venous invasion.
- Weight more than 50 Kg.
- Diameter more than 6.5 cm.
- Ki-67/MIB1 labeling index.