Adrenocortical carcinoma natural history
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Natural History, Complications and Prognosis |
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Diagnosis |
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Treatment |
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Case Study |
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Adrenocortical carcinoma natural history On the Web |
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American Roentgen Ray Society Images of Adrenocortical carcinoma natural history |
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Risk calculators and risk factors for Adrenocortical carcinoma natural history |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
Natural History
Complications
The following are the complications of Adrenocortical carcinoma:
- Cushing's syndrome
- Conn syndrome
- Hypertension
- Virilization
- Feminization
- Local metastasis and tumor thrombus formation
- Paraneoplastic syndrome
- Distant metastasis
Prognosis
ACC, generally, carries a poor prognosis[1] and is unlike most tumours of the adrenal cortex, which are benign (adenomas) and only occasionally cause Cushing's syndrome. Five-year disease-free survival for a complete resection of a stage I-III ACC is approximately 30%.[1] The most important prognostic factors are:
- Age of the patient.
- Stage of the tumor.
Poor prognostic factors:
- Mitotic activity.
- Venous invasion.
- Weight more than 50 Kg.
- Diameter more than 6.5 cm.
- Ki-67/MIB1 labeling index.
References
- ↑ 1.0 1.1 Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update.". J Clin Endocrinol Metab 91 (6): 2027-37. PMID 16551738. Free Full Text.
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