Adrenocortical carcinoma natural history

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Natural History

Complications

The following are the complications of Adrenocortical carcinoma:

Prognosis

ACC, generally, carries a poor prognosis[1] and is unlike most tumours of the adrenal cortex, which are benign (adenomas) and only occasionally cause Cushing's syndrome. Five-year disease-free survival for a complete resection of a stage I-III ACC is approximately 30%.[1] The most important prognostic factors are:

  • Age of the patient.
  • Stage of the tumor.

Poor prognostic factors:

  • Mitotic activity.
  • Venous invasion.
  • Weight more than 50 Kg.
  • Diameter more than 6.5 cm.
  • Ki-67/MIB1 labeling index.

References

  1. 1.0 1.1 Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update.". J Clin Endocrinol Metab 91 (6): 2027-37. PMID 16551738. Free Full Text.

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