Adrenocortical carcinoma epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

The incidence of adrenocortical carcinoma is believed to be 0.72 per million cases per year leading to 0.2% of all cancer deaths in the United States and 0.2 to 0.3 per million children per year worldwide but valid data is lacking. A bimodal distribution is observed, the first one in pediatrics and the second one in the fifth to the sixth decade with a predilection for the female gender.

Epidemiology and Demographics

Incidence

  • The incidence of adrenocortical carcinoma is 7.2 cases per 100,000 individuals per year leading to 0.2% of all cancer deaths in the United States and 3 cases per 100,000 children per year worldwide but valid data is lacking.[1]

Age

  • A bimodal distribution was observed, the first one in pediatrics and the second one in the fifth to the sixth decade.[2]

Gender

  • There is a predilection for the female gender.[3]
  • Girls are also more commonly affected than boys with a ratio of 1.6:1.[4]

References

  1. Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update.". J Clin Endocrinol Metab. 91 (6): 2027–37. PMID 16551738. doi:10.1210/jc.2005-2639. 
  2. Fassnacht M, Allolio B (2009). "Clinical management of adrenocortical carcinoma.". Best Pract Res Clin Endocrinol Metab. 23 (2): 273–89. PMID 19500769. doi:10.1016/j.beem.2008.10.008. 
  3. Luton JP, Cerdas S, Billaud L, Thomas G, Guilhaume B, Bertagna X; et al. (1990). "Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.". N Engl J Med. 322 (17): 1195–201. PMID 2325710. doi:10.1056/NEJM199004263221705. 
  4. Michalkiewicz E, Sandrini R, Figueiredo B, Miranda EC, Caran E, Oliveira-Filho AG; et al. (2004). "Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry.". J Clin Oncol. 22 (5): 838–45. PMID 14990639. doi:10.1200/JCO.2004.08.085. 

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