Adrenocortical carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

Adrenocortical carcinoma can be classified according to hormone production and histological appearance. ACC may secrete cortisol, aldosterone, testosterone or estrogen. Other variants include oncocytic adrenal cortical carcinoma, myxoid adrenal cortical carcinoma, and carcinosarcoma.

Classification

Adrenocortical carcinomas are classified depending on:[1]

Hormones production:

Functional

A Functional adrenocortical carcinoma may produce one or more of the following hormones:[2]

Nonfunctional

A nonfunctional adrenocortical carcinoma does not procuce any of the above hormones.

Histology:

Adrenocortical carcinoma can be classified according to the differentiation of the tissue under the microscope into

  • Well-differentiated
  • Intermediate differentiated
  • Poorly differentiated
  • Anaplastic

Variants

  • Oncocytic adrenal cortical carcinoma
  • Myxoid adrenal cortical carcinoma
  • Carcinosarcoma
  • Adenosquamous adrenocortical carcinoma
  • Clear cell adrenal cortical carcinoma

References


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