Adrenocortical carcinoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2] Ahmad Al Maradni, M.D. [3] Mohammed Abdelwahed M.D[4]

Overview

There are no established causes for adrenocortical carcinoma. The relatively increased incidence in childhood is mainly explained by germline TP53 mutations, which are the underlying genetic cause of ACC in more than 50% to 80% of children.

Causes

  • There are no established causes for adrenocortical carcinoma.
  • The relatively increased incidence in childhood is mainly explained by germline TP53 mutations, which are the underlying genetic cause of ACC in >50% to 80% of children.

Genetics

Hereditary syndromes associated with adrenocortical carcinoma are:

Associated conditions Gene mutations Clinical picture
Lynch syndrome[1]
Neurofibromatosis type 1
MEN1[2]
  • MENIN
Carney complex
BWS[3]

References

  1. Carethers JM, Stoffel EM (2015). "Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer.". World J Gastroenterol. 21 (31): 9253–61. PMC 4541378Freely accessible. PMID 26309352. doi:10.3748/wjg.v21.i31.9253. 
  2. B. Gatta-Cherifi, O. Chabre, A. Murat, P. Niccoli, C. Cardot-Bauters, V. Rohmer, J. Young, B. Delemer, H. Du Boullay, M. F. Verger, J. M. Kuhn, J. L. Sadoul, Ph Ruszniewski, A. Beckers, M. Monsaingeon, E. Baudin, P. Goudet & A. Tabarin (2012). "Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d'etude des Tumeurs Endocrines database". European journal of endocrinology. 166 (2): 269–279. PMID 22084155. doi:10.1530/EJE-11-0679.  Unknown parameter |month= ignored (help)
  3. H. Segers, R. Kersseboom, M. Alders, R. Pieters, A. Wagner & M. M. van den Heuvel-Eibrink (2012). "Frequency of WT1 and 11p15 constitutional aberrations and phenotypic correlation in childhood Wilms tumour patients". European journal of cancer (Oxford, England : 1990). 48 (17): 3249–3256. PMID 22796116. doi:10.1016/j.ejca.2012.06.008.  Unknown parameter |month= ignored (help)

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