Ulcerative colitis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The laboratory findings in a patient with ulcerative colitis include anemia, low albumin, elevated [[ESR]], elevated serum alkaline phosphatase, deranged [[LFTs]] and electrolyte abnormalities.<ref name="pmid17436102">{{cite journal| author=Rodgers AD, Cummins AG| title=CRP correlates with clinical score in ulcerative colitis but not in Crohn's disease. | journal=Dig Dis Sci | year= 2007 | volume= 52 | issue= 9 | pages= 2063-8 | pmid=17436102 | doi=10.1007/s10620-006-9691-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17436102 }} </ref><ref name="pmid15472532">{{cite journal| author=Vermeire S, Van Assche G, Rutgeerts P| title=C-reactive protein as a marker for inflammatory bowel disease. | journal=Inflamm Bowel Dis | year= 2004 | volume= 10 | issue= 5 | pages= 661-5 | pmid=15472532 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15472532 }} </ref> | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
The initial [[diagnosis|diagnostic]] workup for ulcerative colitis includes the following:<ref>Al-Ataie MB, Shinoy VN. eMedicine: Ulcerative colitis. [http://www.emedicine.com/med/topic2336.htm Fulltext].</ref><ref name=ACGGuideline>Ulcerative Colitis Practice Guidelines in Adults, Am. Coll. Gastroenterology, 2004. [http://www.acg.gi.org/physicians/guidelines/UlcerativeColitisUpdate.pdf PDF]</ref><ref name="pmid17436102">{{cite journal| author=Rodgers AD, Cummins AG| title=CRP correlates with clinical score in ulcerative colitis but not in Crohn's disease. | journal=Dig Dis Sci | year= 2007 | volume= 52 | issue= 9 | pages= 2063-8 | pmid=17436102 | doi=10.1007/s10620-006-9691-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17436102 }} </ref><ref name="pmid15472532">{{cite journal| author=Vermeire S, Van Assche G, Rutgeerts P| title=C-reactive protein as a marker for inflammatory bowel disease. | journal=Inflamm Bowel Dis | year= 2004 | volume= 10 | issue= 5 | pages= 661-5 | pmid=15472532 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15472532 }} </ref><ref name="pmid3356884">{{cite journal| author=Prantera C, Davoli M, Lorenzetti R, Pallone F, Marcheggiano A, Iannoni C et al.| title=Clinical and laboratory indicators of extent of ulcerative colitis. Serum C-reactive protein helps the most. | journal=J Clin Gastroenterol | year= 1988 | volume= 10 | issue= 1 | pages= 41-5 | pmid=3356884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3356884 }} </ref><ref name="pmid20634346">{{cite journal| author=van Rheenen PF, Van de Vijver E, Fidler V| title=Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. | journal=BMJ | year= 2010 | volume= 341 | issue= | pages= c3369 | pmid=20634346 | doi=10.1136/bmj.c3369 | pmc=2904879 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20634346 }} [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21242354 Review in: Ann Intern Med. 2011 Jan 18;154(2):JC1-12] </ref> | The initial [[diagnosis|diagnostic]] workup for ulcerative colitis includes the following:<ref>Al-Ataie MB, Shinoy VN. eMedicine: Ulcerative colitis. [http://www.emedicine.com/med/topic2336.htm Fulltext].</ref><ref name=ACGGuideline>Ulcerative Colitis Practice Guidelines in Adults, Am. Coll. Gastroenterology, 2004. [http://www.acg.gi.org/physicians/guidelines/UlcerativeColitisUpdate.pdf PDF]</ref><ref name="pmid17436102">{{cite journal| author=Rodgers AD, Cummins AG| title=CRP correlates with clinical score in ulcerative colitis but not in Crohn's disease. | journal=Dig Dis Sci | year= 2007 | volume= 52 | issue= 9 | pages= 2063-8 | pmid=17436102 | doi=10.1007/s10620-006-9691-2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17436102 }} </ref><ref name="pmid15472532">{{cite journal| author=Vermeire S, Van Assche G, Rutgeerts P| title=C-reactive protein as a marker for inflammatory bowel disease. | journal=Inflamm Bowel Dis | year= 2004 | volume= 10 | issue= 5 | pages= 661-5 | pmid=15472532 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15472532 }} </ref><ref name="pmid3356884">{{cite journal| author=Prantera C, Davoli M, Lorenzetti R, Pallone F, Marcheggiano A, Iannoni C et al.| title=Clinical and laboratory indicators of extent of ulcerative colitis. Serum C-reactive protein helps the most. | journal=J Clin Gastroenterol | year= 1988 | volume= 10 | issue= 1 | pages= 41-5 | pmid=3356884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3356884 }} </ref><ref name="pmid20634346">{{cite journal| author=van Rheenen PF, Van de Vijver E, Fidler V| title=Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis. | journal=BMJ | year= 2010 | volume= 341 | issue= | pages= c3369 | pmid=20634346 | doi=10.1136/bmj.c3369 | pmc=2904879 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20634346 }} [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21242354 Review in: Ann Intern Med. 2011 Jan 18;154(2):JC1-12] </ref> | ||
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*Fecal lactoferrin or calprotectin may be checked to depict intestinal inflammation | *Fecal lactoferrin or calprotectin may be checked to depict intestinal inflammation | ||
* [[Urinalysis]] | * [[Urinalysis]] | ||
* Elevated serum alkaline phosphatase ( | * Elevated serum alkaline phosphatase (in case of uc and psc) | ||
* Stool culture, to rule out parasites and infectious causes. | * Stool culture, to rule out parasites and infectious causes. | ||
* [[C-reactive protein]] can be measured, with an elevated level being another indication of inflammation. | * [[C-reactive protein]] can be measured, with an elevated level being another indication of inflammation. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The laboratory findings in a patient with ulcerative colitis include anemia, low albumin, elevated ESR, elevated serum alkaline phosphatase, deranged LFTs and electrolyte abnormalities.[1][2]
Laboratory Findings
The initial diagnostic workup for ulcerative colitis includes the following:[3][4][1][2][5][6]
- A complete blood count shows
- Anemia
- Thrombocytosis
- A high platelet count
- Elvated ESR (>30mm/hr)
- Low albumin
- Electrolyte studies and renal function tests are done, as chronic diarrhea may be associated with
- Hypokalemia
- Hypomagnesemia
- Pre-renal failure
- Liver function tests are performed to screen for bile duct involvement: primary sclerosing cholangitis.
- Fecal lactoferrin or calprotectin may be checked to depict intestinal inflammation
- Urinalysis
- Elevated serum alkaline phosphatase (in case of uc and psc)
- Stool culture, to rule out parasites and infectious causes.
- C-reactive protein can be measured, with an elevated level being another indication of inflammation.
Although ulcerative colitis is a disease of unknown causation, inquiry should be made as to unusual factors believed to trigger the disease.[4] Factors may include: recent cessation of tobacco smoking; recent administration of large doses of iron or vitamin B6; hydrogen peroxide in enemas or other procedures.
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References
- ↑ 1.0 1.1 Rodgers AD, Cummins AG (2007). "CRP correlates with clinical score in ulcerative colitis but not in Crohn's disease". Dig Dis Sci. 52 (9): 2063–8. doi:10.1007/s10620-006-9691-2. PMID 17436102.
- ↑ 2.0 2.1 Vermeire S, Van Assche G, Rutgeerts P (2004). "C-reactive protein as a marker for inflammatory bowel disease". Inflamm Bowel Dis. 10 (5): 661–5. PMID 15472532.
- ↑ Al-Ataie MB, Shinoy VN. eMedicine: Ulcerative colitis. Fulltext.
- ↑ 4.0 4.1 Ulcerative Colitis Practice Guidelines in Adults, Am. Coll. Gastroenterology, 2004. PDF
- ↑ Prantera C, Davoli M, Lorenzetti R, Pallone F, Marcheggiano A, Iannoni C; et al. (1988). "Clinical and laboratory indicators of extent of ulcerative colitis. Serum C-reactive protein helps the most". J Clin Gastroenterol. 10 (1): 41–5. PMID 3356884.
- ↑ van Rheenen PF, Van de Vijver E, Fidler V (2010). "Faecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic meta-analysis". BMJ. 341: c3369. doi:10.1136/bmj.c3369. PMC 2904879. PMID 20634346. Review in: Ann Intern Med. 2011 Jan 18;154(2):JC1-12