ROR-response element gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

RAR-related orphan receptor "ROR-γ binds DNA with specific sequence motifs AA/TNTAGGTCA (the classic RORE motif) or CT/AG/AGGNCA (the variant RORE motif)^{13, 31}."^[1]

Human genes

Consensus sequences

The consensus sequences for the ROR-response elements are 5'-A(A/T)NTAGGTCA-3' (classic RORE motif) and 5'-C(T/A)(G/A)GGNCA-3' (variant RORE).^[1]

RORE samplings

Copying the apparent consensus sequence for the RORE (ATATAGGTCA) and putting it in "⌘F" finds one located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.

Copying the apparent consensus sequence for the variant RORE (CTGGGACA) and putting it in "⌘F" finds two located between ZSCAN22 and A1BG and one between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence A(A/T)NTAGGTCA (starting with SuccessablesRORE.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for A(A/T)NTAGGTCA, 1, ATATAGGTCA at 1532.
positive strand, negative direction, looking for A(A/T)NTAGGTCA, 0.
positive strand, positive direction, looking for A(A/T)NTAGGTCA, 0.
negative strand, positive direction, looking for A(A/T)NTAGGTCA, 0.
complement, negative strand, negative direction, looking for T(A/T)NATCCAGT, 0.
complement, positive strand, negative direction, looking for T(A/T)NATCCAGT, 1, ATATAGGTCA at 1532.
complement, positive strand, positive direction, looking for T(A/T)NATCCAGT, 0.
complement, negative strand, positive direction, looking for T(A/T)NATCCAGT, 0.
inverse complement, negative strand, negative direction, looking for TGACCTAN(A/T)T, 0.
inverse complement, positive strand, negative direction, looking for TGACCTAN(A/T)T, 0.
inverse complement, positive strand, positive direction, looking for TGACCTAN(A/T)T, 0.
inverse complement, negative strand, positive direction, looking for TGACCTAN(A/T)T, 0.
inverse negative strand, negative direction, looking for ACTGGATN(A/T)A, 0.
inverse positive strand, negative direction, looking for ACTGGATN(A/T)A, 0.
inverse positive strand, positive direction, looking for ACTGGATN(A/T)A, 0.
inverse negative strand, positive direction, looking for ACTGGATN(A/T)A, 0.

RORE distal promoters

Negative strand: ATATAGGTCA at 1532.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

References

↑ ^1.0 ^1.1 Junjian Wang, June X. Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C. Yang, Maggie C. Louie, Alexander D. Borowsky, Allen C. Gao, Christopher P. Evans, Kit S. Lam, Jianzhen Xu, Hsing-Jien Kung, Ronald M. Evans, Yong Xu, and Hong-Wu Chen (May 2016). "ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer". Nature Medicine. 22 (5): 488–496. doi:10.1038/nm.4070. PMID 27019329. Retrieved 6 September 2020.

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