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==Overview==
==Overview==
Clinically, [[Menopause]] does not happen suddenly, but it passes through stages until it reaches the permanent cessation of the [[menstrual cycle]]. It is classified according to pathological causes into three types including [[physiological]] [[menopause]], [[Premature Menopause]]/Early [[menopause]], and Induced [[Menopause]]. [[Physiology|Physiological]] [[menopause]] is [[amenorrhea]] without any [[pathological]] [[diseases]] and [[medical conditions]]. As [[women]] age, the production of [[estrogen]] and [[progesterone]] from the [[ovaries]] begins to decrease gradually. [[Premature menopause]] is the permanent cessation of the [[menstrual cycle]] of the age of 40 because of [[premature ovarian failure]]" it is the permanent loss of [[ovarian]] function, but early [[menopause]] is a cessation of the [[menstrual cycle]] between 40 and 45 of age, and both of them happen because of several medical [[diseases]] as ( [[Autoimmune disease]], [[thyroid disease]], [[metabolic disorder]], [[diabetes mellitus]]). Induced [[menopause]] is the permanent cessation of the [[menstrual cycle]] because of [[Complication (medicine)|complication]] of medical treatment such as [[chemotherapy]], and [[radiotherapy]].
[[Menopause]] is classified according to [[causes]] into three types including natural [[menopause]], [[Premature Menopause|premature menopause]]/[https://www.healthline.com/health/menopause/causes-early early menopause], and [https://www.menopause.org/for-women/menopauseflashes/menopause-symptoms-and-treatments/instant-help-for-induced-menopause induced menopause]. Natural    [[menopause]], does not happen suddenly, but it passes through 3 stages include [[perimenopause]], [[Perimenopause|premenopause]], and [[Menopause|postmenopause]]. [[Premature menopause]] because of [[premature ovarian failure]] and several medical [[diseases]]. [https://www.menopause.org/for-women/menopauseflashes/menopause-symptoms-and-treatments/instant-help-for-induced-menopause Induced menopause] because of bilateral [[oophorectomy]], [[salpingo-oophorectomy]], and [[hysterectomy]]. in addition to          [[Complication (medicine)|complication]] of [[chemotherapy]] and [[radiotherapy]].
 
==Classification of Menopause==
==Classification of Menopause==
[[Menopause]] is [[classified]] according to [[pathological]] causes into three types :
[[Menopause]] is [[classified]] according to [[causes]] into three types :
 
*[[physiological]] [[menopause]]
*[[Premature Menopause]]/Early [[menopause]]
*Induced [[Menopause]]
 
===<big>'''Physiological Menopause'''</big>===
[[Physiology|Physiological]] [[menopause]] is [[amenorrhea]] without any [[pathological]] [[diseases]] and [[medical conditions]]. As [[women]] age, the production of [[estrogen]] and [[progesterone]] from the [[ovaries]] begins to decrease gradually, as these [[hormones]] play a major role in the occurrence of [[menstruation]] regularly, and as a result of the [[deficiency]] of these [[hormones]] occurs [[menopause]].
 
====<big>Perimenopause or " menopause transition"</big>====
[[Perimenopause]] means the [[menopause]] transition years, the years before and after the last period ever, when the majority of [[women]] find that they undergo at least some [[symptoms]] of [[hormonal]] change and fluctuation, such as [[Hot flash|hot flashes]], [[mood]] changes, [[insomnia]], [[fatigue]], irregular [[menses]], etc.
 
During [[perimenopause]], the production of most of the reproductive [[hormones]], including [[estrogen]]s and [[progestin]], diminishes and becomes more irregular, often with wide and unpredictable fluctuations in levels. During this period, [[fertility]] diminishes.
 
[[Symptoms]] of [[perimenopause]] can begin as early as age 35, although most [[women]] become aware of them about 10 years later than this. [[Perimenopause]] can last for a few years, or ten years or even longer. In this respect, it resembles [[puberty]], a similar process that surrounds [[menarche]]. [[Menopause]] can usefully be compared to "[[puberty]] in reverse", and the [[psychological]] adjustments that take place over this period can be compared to [[adolescence]]. The actual duration and severity of [[perimenopause]] in any individual woman cannot be predicted in advance or during the process.
 
Not every woman suffers [[symptoms]] during [[perimenopause]]. Approximately one-third of all [[women]] get no noticeable [[symptoms]] other than their periods becoming erratic and then stopping. Another one-third of [[women]] have moderate [[symptoms]]. The remaining one-third of [[women]] have very strong [[symptoms]] which tend to have a longer duration. The tendency to have very strong [[perimenopause]] maybe [[inherited]] in some cases.
 
One piece of recent research appears to show that [[melatonin]] supplementation in [[perimenopausal]] women can produce a highly significant improvement in [[thyroid]] function and [[gonadotropin]] levels, as well as restoring [[fertility]] and [[menstruation]] and preventing the [[depression]] associated with the [[menopause]]<ref name="Bellipanni_2005">Bellipanni G, DI Marzo F, Blasi F, et al. Effects of melatonin in perimenopausal and menopausal women: our personal experience. 2005. Ann N Y Acad Sci 1057:393-402. [[Digital_object_identifier|DOI]]: [http://dx.doi.org/10.1196/annals.1356.030 10.1196/annals.1356.030] '''PMID 16399909'''</ref>.
 
====<big>Premenopause</big>====
Premenopause is a word used to describe the years leading up to the last period ever when the levels of reproductive [[hormones]] are already becoming lower and more erratic, and [[symptoms]] of [[hormone]] withdrawal may be present.
 
====<big>Postmenopause</big>====
Postmenopause is all of the time in a woman's life that takes place after her last period ever, or more accurately, all of the time that follows the point when her [[ovaries]] become inactive.


A woman is considered in post-[[menopause]] after [[amenorrhea]] more than 12 months, not even any spotting. When she reaches that point, she is one year into post-menopause. The reason for this delay in declaring a woman post-menopausal is because periods become very erratic at this time of life, and therefore a reasonably long period is necessary to be sure that the cycling has ceased.
*Natural [[menopause]]
*[[Premature Menopause]]/[https://www.healthline.com/health/menopause/causes-early Early menopause]
*[[Surgery|Surgical]]/[https://www.menopause.org/for-women/menopauseflashes/menopause-symptoms-and-treatments/instant-help-for-induced-menopause Induced Menopause]


In [[women]] who have no [[uterus]], and therefore have no periods, post-[[menopause]] can be determined by a [[blood test]] which can reveal the very high levels of [[Follicle-stimulating hormone|Follicle Stimulating Hormone]] ([[FSH]]) that are typical of post-[[menopausal]] [[women]].
==='''Physiological Menopause'''===
[[Physiology|Physiological]] [[menopause]] is [[amenorrhea]], it passes gradually through 3 stages until it reaches the permanent cessation of the [[menstrual cycle]]


A woman's reproductive [[hormone]] levels continue to drop and fluctuate for some time into post-[[menopause]], so any [[hormone]] [[withdrawal symptoms]] that a woman may be experiencing do not necessarily stop right away but may take quite some time, even several years, to disappear completely.
*[[Perimenopause|Premenopause]] is a word used to describe the years leading up to the last [[period]] ever when the levels of [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/reproductive-hormone reproductive hormones] are already becoming lower and more erratic, and [[symptoms]] of [https://pubmed.ncbi.nlm.nih.gov/23421366/ hormone withdrawal] may be present.
*[[Perimenopause]] or "[[menopause]] transition"means the [[menopause]] transition years, the years before and after the last period ever, when the majority of [[women]] find that they undergo at least some [[symptoms]] of [[hormonal]] change and fluctuation, such as [[Hot flash|hot flashes]],  [[Mood disturbances|mood changes]], [[insomnia]], [[fatigue]], [https://my.clevelandclinic.org/health/diseases/14633-abnormal-menstruation-periods irregular menses]. During [[perimenopause]], the production of most of the [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/reproductive-hormone reproductive hormones], including [[estrogen]]s and [[progestin]], diminishes and becomes more irregular, often with wide and unpredictable fluctuations in levels. During this [[period]], [[fertility]] diminishes.  [[Symptoms]] of [[perimenopause]] can begin as early as [[age]] 35, although most [[women]] become aware of them about 10 years later than this. [[Perimenopause]] can last for a few years, or ten years or even longer.
*[[Menopause|Postmenopause]], a [[Women|woman]] has considered in [[Menopause|post-menopause]] after [[amenorrhea]] more than 12 months, not even any spotting. When she reaches that point, she is one year into [[Menopause|post-menopause]]. The reason for this delay in declaring a woman [[Menopause|post-menopausal]] is because [[periods]] become very erratic at this time of life, and therefore a reasonably long period is necessary to be sure that the [[Menses|cycling]] has ceased. A woman's [https://www.cancer.gov/publications/dictionaries/cancer-terms/def/reproductive-hormone reproductive hormone] levels continue to drop and fluctuate for some time into post-[[menopause]], so any [https://pubmed.ncbi.nlm.nih.gov/23421366/ hormone withdrawal symptoms] that a woman may be experiencing do not necessarily stop right away but may take quite some time, even several years, to disappear completely.<ref name="pmid15345086">{{cite journal| author=Cheung AM, Chaudhry R, Kapral M, Jackevicius C, Robinson G| title=Perimenopausal and Postmenopausal Health. | journal=BMC Womens Health | year= 2004 | volume= 4 Suppl 1 | issue=  | pages= S23 | pmid=15345086 | doi=10.1186/1472-6874-4-S1-S23 | pmc=2096694 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15345086  }} </ref>


===<big>'''Premature Menopause/Early menopause'''</big>===
===Premature Menopause/Early menopause===
[[Premature menopause]] is the permanent cessation of the [[menstrual cycle]] of the age of 40 because of [[premature ovarian failure]]" it is the permanent loss of [[ovarian]] function and this condition affects approximately 1% of [[women]]". But early menopause is a cessation of the [[menstrual cycle]] between 40 and 45 of age.<ref>http://www.menopause.org/docs/default-source/2014/nams-recomm-for-clinical-care.pdf</ref>


About 5% of [[women]] have early [[menopause]] and both of them happen because of several medical [[diseases]] as ( [[Autoimmune disease]], [[thyroid disease]], [[metabolic disorder]], [[diabetes mellitus]]).<ref>name=":0"womenshealth.gov/menopause/early-or-premature-menopause/#2</ref>
*[[Premature menopause]] is the permanent cessation of the [[menstrual cycle]] under 40 of [[age]] and [https://my.clevelandclinic.org/health/diseases/21138-premature-and-early-menopause early menopause] (between [[Age|ages]] 40 and 45 years).<ref name="pmid19733988">{{cite journal| author=Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA| title=Premature menopause or early menopause: long-term health consequences. | journal=Maturitas | year= 2010 | volume= 65 | issue= 2 | pages= 161-6 | pmid=19733988 | doi=10.1016/j.maturitas.2009.08.003 | pmc=2815011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19733988  }} </ref>
*It is because of [[premature ovarian failure]] and several [[medical]] [[diseases]].<ref>{{cite journal| author=Okeke T, Anyaehie U, Ezenyeaku C| title=Premature menopause. | journal=Ann Med Health Sci Res | year= 2013 | volume= 3 | issue= 1 | pages= 90-5 | pmc=3634232 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23634337  }} </ref>


===<big>'''Induced Menopause'''</big>===
===Surgical/Induced Menopause===
Induced [[menopause]] is the permanent cessation of the [[menstrual cycle]] because of [[Complication (medicine)|complication]] of medical treatment such as [[chemotherapy]], and [[radiotherapy]] for [[treatment]] of [[cancer]] and [[pelvic]] surgery such as Bilateral [[oophorectomy]] that means remove [[ovaries]] which are sometimes done with removal of the [[Fallopian tubes]] ([[salpingo-oophorectomy]]) so remove [[ovaries]] with or without tubes and  [[Hysterectomy]] that means remove [[uterus]].The [[causes]] of  [[menopause]] after these [[surgery]] are the sudden quickly drop in [[Hormone|hormone levels]] after [[oophorectomy]]  and decrease in the [[Mechanism (biology)|mechanism]] of [[feedback]]  after [[Hysterectomy]] although ovarian [[hormones]] are still produced . The surgical [[menopause]]  [[symptoms]] may be more severe like [[hot flushes]] <ref>https://www.menopause.org/for-women/menopauseflashes/menopause-symptoms-and-treatments/instant-help-for-induced-menopause</ref>


*[https://www.menopause.org/for-women/menopauseflashes/menopause-symptoms-and-treatments/instant-help-for-induced-menopause Induced menopause] is the permanent cessation of the [[menstrual cycle]] because of [[Complication (medicine)|complication]] of [[medical treatment]] such as [[chemotherapy]], and [[radiotherapy]] for [[treatment]] of [[cancer]] and  [[Surgery operation|surgery]] such as bilateral [[oophorectomy]], [[salpingo-oophorectomy]], and [[hysterectomy]].
*The [[causes]] of  [[menopause]] after these [[surgery]] are the sudden quickly drop in [[Hormone|hormone levels]] after [[oophorectomy]]  and decrease in the [[Mechanism (biology)|mechanism]] of [[feedback]]  after [[Hysterectomy]] although [[ovarian hormones]] are still produced .The surgical [https://www.mayoclinic.org/diseases-conditions/menopause/symptoms-causes/syc-20353397 menopausal symptoms] may be more severe like [[hot flushes]].<ref name="pmid31416275">{{cite journal| author=Secoșan C, Balint O, Pirtea L, Grigoraș D, Bălulescu L, Ilina R| title=Surgically Induced Menopause-A Practical Review of Literature. | journal=Medicina (Kaunas) | year= 2019 | volume= 55 | issue= 8 | pages=  | pmid=31416275 | doi=10.3390/medicina55080482 | pmc=6722518 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31416275  }} </ref>


==References==
==References==

Latest revision as of 05:40, 11 February 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Rahmah Al-Edresi, M.D.[2]

Overview

Menopause is classified according to causes into three types including natural menopause, premature menopause/early menopause, and induced menopause. Natural menopause, does not happen suddenly, but it passes through 3 stages include perimenopause, premenopause, and postmenopause. Premature menopause because of premature ovarian failure and several medical diseases. Induced menopause because of bilateral oophorectomy, salpingo-oophorectomy, and hysterectomy. in addition to complication of chemotherapy and radiotherapy.

Classification of Menopause

Menopause is classified according to causes into three types :

Physiological Menopause

Physiological menopause is amenorrhea, it passes gradually through 3 stages until it reaches the permanent cessation of the menstrual cycle

Premature Menopause/Early menopause

Surgical/Induced Menopause

References

  1. Cheung AM, Chaudhry R, Kapral M, Jackevicius C, Robinson G (2004). "Perimenopausal and Postmenopausal Health". BMC Womens Health. 4 Suppl 1: S23. doi:10.1186/1472-6874-4-S1-S23. PMC 2096694. PMID 15345086.
  2. Shuster LT, Rhodes DJ, Gostout BS, Grossardt BR, Rocca WA (2010). "Premature menopause or early menopause: long-term health consequences". Maturitas. 65 (2): 161–6. doi:10.1016/j.maturitas.2009.08.003. PMC 2815011. PMID 19733988.
  3. Okeke T, Anyaehie U, Ezenyeaku C (2013). "Premature menopause". Ann Med Health Sci Res. 3 (1): 90–5. PMC 3634232.
  4. Secoșan C, Balint O, Pirtea L, Grigoraș D, Bălulescu L, Ilina R (2019). "Surgically Induced Menopause-A Practical Review of Literature". Medicina (Kaunas). 55 (8). doi:10.3390/medicina55080482. PMC 6722518 Check |pmc= value (help). PMID 31416275.


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