Leukocyte alkaline phosphatase: Difference between revisions

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__NOTOC__
__NOTOC__
{{SI}}
{{SI}}
{{CMG}}; {{VR}}
{{CMG}}; {{AE}} {{VR}}


{{SK}} LAP
{{SK}} LAP


== Overview ==   
== Overview ==   
Leukocyte alkaline phosphatase is an [[enzyme]] found within [[white blood cells]]. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in [[polycythemia vera]], [[essential thrombocytosis]], [[myelofibrosis|primary myelofibrosis]] and [[leukemoid reaction]]. Lower levels are found in [[chronic myelogenous leukemia]], [[aplastic anemia]], [[paroxysmal nocturnal hemoglobinuria]] and [[acute myelogenous leukemia]].
Leukocyte alkaline phosphatase is an [[enzyme]] found within [[white blood cells]]. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in [[polycythemia vera]], [[essential thrombocytosis]], [[myelofibrosis|primary myelofibrosis]] and [[leukemoid reaction]]. Lower levels are found in [[chronic myelogenous leukemia]], [[aplastic anemia]], [[paroxysmal nocturnal hemoglobinuria]] and [[acute myelogenous leukemia]].


==Causes of Increased Leukocyte alkaline phosphatase==
==Causes of Increased Leukocyte alkaline phosphatase==
===Life Threatening Causes===
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
*[[Appendicitis]]
*[[Blood transfusion]]
*[[Burns]]
*[[Diabetic coma]]
*[[Diabetic ketoacidosis]]
*[[Eclampsia]]
*[[Epidural hemorrhage]]
*[[Hemorrhagic shock]]
*[[Fulminant hepatic necrosis|Hepatic necrosis]]
*[[Venom|Insect venoms]]
*[[Intracerebral hemorrhage]]
*[[Ischemic colitis]]
*[[Myocardial infarction]]
*[[Osteomyelitis]]
*[[Pelvic abscess]]
===Common Causes===
===Common Causes===
*[[Acute leukemia]]
*[[Acute leukemia]]
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[All-trans retinoic acid]], [[arsphenamine]], [[catecholamines ]], [[corticosteroids]], [[dapsone]], [[digitalis]], [[neuroleptic malignant syndrome]], [[oral contraceptives]], [[phenacetin]], [[quinidine]], [[sulfa drugs]]
|bgcolor="Beige"| [[All-trans retinoic acid]], [[arsphenamine]], [[catecholamines]], [[corticosteroids]], [[dapsone]], [[digitalis]], [[neuroleptic malignant syndrome]], [[oral contraceptives]], [[phenacetin]], [[quinidine]], [[sulfa drugs]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Asplenia|Congenital asplenia]], [[neutropenia|congenital neutropenia ]], [[Down syndrome]], [[familial cold urticaria|familial cold autoinflammatory syndrome]], [[Fanconi anemia]], [[hereditary neutrophilia]], [[hyposplenism]], [[Klinefelter syndrome]], [[Kostmann syndrome]], [[Leukocyte adhesion deficiency|leukocyte adhesion factor deficiency]], [[Pelger-Huet anomaly]], [[rac|rac mutation]]
|bgcolor="Beige"| [[Asplenia|Congenital asplenia]], [[neutropenia|congenital neutropenia]], [[Down syndrome]], [[familial cold urticaria|familial cold autoinflammatory syndrome]], [[Fanconi anemia]], [[hereditary neutrophilia]], [[hyposplenism]], [[Klinefelter syndrome]], [[Kostmann syndrome]], [[Leukocyte adhesion deficiency|leukocyte adhesion factor deficiency]], [[Pelger-Huet anomaly]], [[rac|rac mutation]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[acute myelogenous leukemia]], [[agnogenic myeloid metaplasia]], [[bronchogenic carcinoma ]], [[gastric carcinoma]], [[hairy cell leukemia]], [[Hodgkin's lymphoma]], [[paraneoplastic phenomenon]], [[renal carcinoma]], [[squamous cell carcinoma]]
|bgcolor="Beige"| [[Acute lymphoblastic leukemia]], [[acute myelogenous leukemia]], [[agnogenic myeloid metaplasia]], [[bronchogenic carcinoma]], [[gastric carcinoma]], [[hairy cell leukemia]], [[Hodgkin's lymphoma]], [[paraneoplastic phenomenon]], [[renal carcinoma]], [[squamous cell carcinoma]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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*[[Arsphenamine]]
*[[Arsphenamine]]
*[[Blood transfusion]]
*[[Blood transfusion]]
*[[Bronchogenic carcinoma ]]
*[[Bronchogenic carcinoma]]
*[[Burkholderia mallei ]]
*[[Burkholderia mallei]]
*[[Burns]]
*[[Burns]]
*[[Camphor]]
*[[Camphor]]
*[[Catecholamines ]]
*[[Catecholamines]]
*[[Cellulitis]]
*[[Cellulitis]]
*[[Cesarean delivery]]
*[[Cesarean delivery]]
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*[[Coccidioides immitis]]
*[[Coccidioides immitis]]
*[[Asplenia|Congenital asplenia]]
*[[Asplenia|Congenital asplenia]]
*[[Neutropenia|Congenital neutropenia ]]
*[[Neutropenia|Congenital neutropenia]]
*[[Corticosteroids]]
*[[Corticosteroids]]
*[[Cushing's disease]]
*[[Cushing's disease]]
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*[[Fanconi anemia]]
*[[Fanconi anemia]]
*[[G-CSF]]
*[[G-CSF]]
{{col-break|width=33%}}
*[[Gastric carcinoma]]
*[[Gastric carcinoma]]
{{col-break|width=33%}}
*[[Giant cell arteritis]]
*[[Giant cell arteritis]]
*[[GM-CSF]]
*[[GM-CSF]]
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*[[Otitis media]]
*[[Otitis media]]
*[[Panic disorders]]
*[[Panic disorders]]
*[[Paraneoplastic phenomenon ]]
*[[Paraneoplastic phenomenon]]
*[[Pelger-Huet anomaly]]
*[[Pelger-Huet anomaly]]
*[[Pelvic abscess]]
*[[Pelvic abscess]]
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{{col-end}}
{{col-end}}


==Causes of Decreased Leukocyte alkaline phosphatase==
==Causes of Decreased Leukocyte Alkaline Phosphatase==
===Life Threatening Causes===
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
 
*[[Burns]]
*[[Epinephrine]]
*[[Respiratory alkalosis]]
*[[Salicylate|Salicylate toxicity]]
*[[Terbutaline|Terbutaline toxicity]]
 
===Common Causes===
===Common Causes===
* [[Aplastic anemia]]
* [[Aplastic anemia]]
* [[Chronic Myelogenous Leukemia]]
* [[Chronic myelogenous leukemia]]
* [[Hypophosphatemia]]<ref name="Gaasbeek-2005">{{Cite journal  | last1 = Gaasbeek | first1 = A. | last2 = Meinders | first2 = AE. | title = Hypophosphatemia: an update on its etiology and treatment. | journal = Am J Med | volume = 118 | issue = 10 | pages = 1094-101 | month = Oct | year = 2005 | doi = 10.1016/j.amjmed.2005.02.014 | PMID = 16194637 }}</ref>
* [[Hypophosphatemia]]<ref name="Gaasbeek-2005">{{Cite journal  | last1 = Gaasbeek | first1 = A. | last2 = Meinders | first2 = AE. | title = Hypophosphatemia: an update on its etiology and treatment. | journal = Am J Med | volume = 118 | issue = 10 | pages = 1094-101 | month = Oct | year = 2005 | doi = 10.1016/j.amjmed.2005.02.014 | PMID = 16194637 }}</ref>
* [[Iron deficiency anemia]]
* [[Iron deficiency anemia]]
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Acetazolamide]],  [[albuterol]],  [[dopamine]],  [[epinephrine]],  [[glucagon]],  [[granulocyte colony-stimulating factor]],  [[insulin]], [[salicylate]], [[corticosteroids | systemic corticosteroids]],  [[terbutaline]]
|bgcolor="Beige"| [[Acetazolamide]],  [[albuterol]],  [[dopamine]],  [[epinephrine]],  [[glucagon]],  [[granulocyte colony-stimulating factor]],  [[insulin]], [[salicylate]], [[corticosteroids|systemic corticosteroids]],  [[terbutaline]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Addison's disease]],  [[calcitonin]],  [[diabetes mellitus]],  [[hungry bone syndrome]],  [[hyperparathyroidism]],  [[hyperthyroidism]],  [[hypoparathyroidism]],  [[hypothyroidism ]]
|bgcolor="Beige"| [[Addison's disease]],  [[calcitonin]],  [[diabetes mellitus]],  [[Parathyroidectomy|hungry bone syndrome]],  [[hyperparathyroidism]],  [[hyperthyroidism]],  [[hypoparathyroidism]],  [[hypothyroidism]]
|-  
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Bacterial overgrowth]], [[bariatric surgery ]], [[blind loops]], [[carcinoid syndrome]],  [[carcinoma of pancreas]],  [[celiac disease]],  [[chronic pancreatitis]],  [[Crohn's disease]],  [[cystic fibrosis]],  [[eosinophilic gastroenteritis]],  [[Diphyllobothrium | fish tapeworm]],  [[giardia lamblia]],  [[hepatic failure]],  [[hookworm]],  [[Tuberculosis | intestinal tuberculosis]],  [[lactose intolerance]],  [[primary bile acid diarrhea]],  [[radiation enteritis]],  [[refeeding syndrome]],  [[roundworm ]],  [[short bowel syndrome]],  [[sucrose intolerance]],  [[traveller's diarrhoea]],  [[tropical sprue]],  [[Whipple's disease]]  
|bgcolor="Beige"| [[Bacterial overgrowth]], [[bariatric surgery]], [[blind loop syndrome]], [[carcinoid syndrome]],  [[carcinoma of pancreas]],  [[celiac disease]],  [[chronic pancreatitis]],  [[Crohn's disease]],  [[cystic fibrosis]],  [[eosinophilic gastroenteritis]],  [[Diphyllobothrium | fish tapeworm]],  [[giardia lamblia]],  [[hepatic failure]],  [[hookworm]],  [[Tuberculosis | intestinal tuberculosis]],  [[lactose intolerance]],  [[Bile acid malabsorption|primary bile acid diarrhea]],  [[radiation enteritis]],  [[refeeding syndrome]],  [[roundworm]],  [[short bowel syndrome]],  [[sucrose intolerance]],  [[traveler's diarrhea]],  [[tropical sprue]],  [[Whipple's disease]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Abetalipoproteinemia]],  [[beta thalassemia]],  [[cystic fibrosis]],  [[hereditary hyperphosphatasia]],  [[X-linked_hypophosphatemia | hereditary hypophosphatemia]],  [[Autosomal dominant hypophosphatemic rickets | hereditary hypophosphatemic rickets]],  [[hereditary vitamin D-resistant rickets]],  [[Monoclonal gammopathy of undetermined significance | IgG monoclonal gammopathy]],  [[malignant histiocytosis]],  [[myeloproliferative variants of hypereosinophilic sundrome]],  [[paroxysmal nocturnal hemoglobinuria]],  [[Myelofibrosis | primary myelofibrosis]],  [[trilineage dysplasia]]
|bgcolor="Beige"| [[Abetalipoproteinemia]],  [[beta thalassemia]],  [[cystic fibrosis]],  [[hyperphosphatasia|hereditary hyperphosphatasia]],  [[X-linked_hypophosphatemia | hereditary hypophosphatemia]],  [[Autosomal dominant hypophosphatemic rickets | hereditary hypophosphatemic rickets]],  [[Vitamin D resistant rickets|hereditary vitamin D-resistant rickets]],  [[Monoclonal gammopathy of undetermined significance | IgG monoclonal gammopathy]],  [[malignant histiocytosis]],  [[hypereosinophilic syndrome|myeloproliferative variants of hypereosinophilic syndrome]],  [[paroxysmal nocturnal hemoglobinuria]],  [[Myelofibrosis | primary myelofibrosis]],  [[dysplasia|trilineage dysplasia]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| [[Acute myelogenous leukemia]],  [[aplastic anemia]],  [[Chronic myelogenous leukemia | atypical chronic myeloid leukemia ]],  [[beta thalassemia ]],  [[blood transfusion ]],  [[chronic eosinophilic leukemia]],  [[chronic myelogenous leukemia]],  [[chronic myelomonocytic leukemia]],  [[erythroblastosis fetalis]],  [[essential thrombocythemia]],  [[fanconi syndrome]],  [[hemolysis]],  [[idiopathic hypereosinophilic syndrome]],  [[idiopathic thrombocytopenic purpura]],  [[iron deficiency anemia]],  [[myeloproliferative variants of hypereosinophilic sundrome]],  [[Non-Hodgkin lymphoma]],  [[paroxysmal nocturnal hemoglobinuria]],  [[pernicious anemia]],  [[Myelofibrosis | primary myelofibrosis]], [[refractory anemia with ringed sideroblasts]],  [[Thrombocytopenia | refractory thrombocytopenia ]],  [[sickle cell disease]],  [[sideroachrestic anemia]],  [[sideroblastic anemia]],  [[thrombocytopenic purpura]]
|bgcolor="Beige"| [[Acute myelogenous leukemia]],  [[aplastic anemia]],  [[Chronic myelogenous leukemia |atypical chronic myeloid leukemia]],  [[beta thalassemia]],  [[blood transfusion]],  [[chronic eosinophilic leukemia]],  [[chronic myelogenous leukemia]],  [[chronic myelomonocytic leukemia]],  [[erythroblastosis fetalis]],  [[essential thrombocythemia]],  [[fanconi syndrome]],  [[hemolysis]],  [[idiopathic hypereosinophilic syndrome]],  [[idiopathic thrombocytopenic purpura]],  [[iron deficiency anemia]],  [[hypereosinophilic syndrome|myeloproliferative variants of hypereosinophilic syndrome]],  [[non-Hodgkin lymphoma]],  [[paroxysmal nocturnal hemoglobinuria]],  [[pernicious anemia]],  [[Myelofibrosis | primary myelofibrosis]], [[Thrombocytopenia | refractory thrombocytopenia]],  [[sickle cell disease]],  [[sideroachrestic anemia]],  [[sideroblastic anemia]],  [[thrombocytopenic purpura]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| [[Bariatric surgery ]],  [[blood transfusion ]],  [[gastrectomy]],  [[vagotomy]]
|bgcolor="Beige"| [[Bariatric surgery]],  [[blood transfusion]],  [[gastrectomy]],  [[vagotomy]]
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"|  [[Diphyllobothrium | fish tapeworm]],  [[giardia lamblia]],  [[Histoplasmosis | histoplasmosis endocarditis]],  [[HIV]],  [[hookworm]],  [[infectious mononucleosis]],  [[Tuberculosis | intestinal tuberculosis]],  [[roundworm ]], [[traveller's diarrhea]]
|bgcolor="Beige"|  [[Diphyllobothrium |fish tapeworm]],  [[giardia lamblia]],  [[Histoplasmosis |histoplasmosis endocarditis]],  [[HIV]],  [[hookworm]],  [[infectious mononucleosis]],  [[Tuberculosis | intestinal tuberculosis]],  [[roundworm]], [[traveler's diarrhea]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"|  [[Osteoarthritis | degenerative arthritis]],  [[Autosomal dominant hypophosphatemic rickets | hereditary hypophosphatemic rickets]],  [[oncogenic osteomalacia]],  [[osteoarthritis]],  [[osteomalacia]]
|bgcolor="Beige"|  [[Osteoarthritis | degenerative arthritis]],  [[Autosomal dominant hypophosphatemic rickets |hereditary hypophosphatemic rickets]],  [[oncogenic osteomalacia]],  [[osteoarthritis]],  [[osteomalacia]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| [[Dementia]],  [[ganglioneuroma | thoracic ganglioneuroma]]  
|bgcolor="Beige"| [[Dementia]],  [[ganglioneuroma |thoracic ganglioneuroma]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Bacterial overgrowth]],  [[bariatric surgery ]],  [[blind loops]],  [[celiac disease]],  [[chronic pancreatitis]],  [[chronic renal failure]],  [[Crohn's disease]],  [[gastrectomy]],  [[X-linked_hypophosphatemia | hereditary hypophosphatemia]], [[hereditary vitamin D-resistant rickets]],  [[hungry bone syndrome]],  [[hypophosphatemia]],  [[primary bile acid diarrhea]],  [[radiation enteritis]],  [[refeeding syndrome]],  [[Respiratory alkalosis | respiratory alkalosis]],  [[short bowel syndrome]],  [[sucrose intolerance]],  [[tropical sprue]],  [[Whipple's disease]]
|bgcolor="Beige"| [[Bacterial overgrowth]],  [[bariatric surgery]],  [[blind loop syndrome]],  [[celiac disease]],  [[chronic pancreatitis]],  [[chronic renal failure]],  [[Crohn's disease]],  [[gastrectomy]],  [[X-linked_hypophosphatemia |hereditary hypophosphatemia]], [[vitamin D resistant rickets|hereditary vitamin D-resistant rickets]],  [[Parathyroidectomy|hungry bone syndrome]],  [[hypophosphatemia]],  [[Bile acid malabsorption|primary bile acid diarrhea]],  [[radiation enteritis]],  [[refeeding syndrome]],  [[respiratory alkalosis]],  [[short bowel syndrome]],  [[sucrose intolerance]],  [[tropical sprue]],  [[Whipple's disease]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| [[Acute myelogenous leukemia]],  [[Chronic myelogenous leukemia | atypical chronic myelogenous leukemia ]],  [[carcinoid syndrome]],  [[carcinoma of pancreas]],  [[chronic eosinophilic leukemia]],  [[chronic myelogenous leukemia]],  [[chronic myelomonocytic leukemia]],  [[malignant diseases]],  [[malignant lymphoma]],  [[Non-Hodgkin lymphoma]],  [[oncogenic osteomalacia]],  [[ganglioneuroma | thoracic ganglioneuroma]]  
|bgcolor="Beige"| [[Acute myelogenous leukemia]],  [[Chronic myelogenous leukemia |atypical chronic myelogenous leukemia]],  [[carcinoid syndrome]],  [[carcinoma of pancreas]],  [[chronic eosinophilic leukemia]],  [[chronic myelogenous leukemia]],  [[chronic myelomonocytic leukemia]],  [[malignant diseases]],  [[malignant lymphoma]],  [[non-Hodgkin lymphoma]],  [[oncogenic osteomalacia]],  [[ganglioneuroma|thoracic ganglioneuroma]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| [[Cystic fibrosis]],  [[Respiratory alkalosis | respiratory alkalosis]]
|bgcolor="Beige"| [[Cystic fibrosis]],  [[Respiratory alkalosis |respiratory alkalosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Chronic renal failure]],  [[post renal transplant]]
|bgcolor="Beige"| [[Chronic renal failure]],  [[renal transplant]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Blood transfusion ]],  [[collagen vascular diseases]],  [[fibromyalgia]],  [[pernicious anemia]],  [[post renal transplant]],  [[sarcoidosis]],  [[systemic lupus erythematosus]],  [[systemic sclerosis ]]
|bgcolor="Beige"| [[Blood transfusion]],  [[collagen vascular diseases]],  [[fibromyalgia]],  [[pernicious anemia]],  [[renal transplant]],  [[sarcoidosis]],  [[systemic lupus erythematosus]],  [[systemic sclerosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
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|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| [[Alcohol]],  [[amyloidosis]],  [[citrated blood sample]],  [[EDTA | EDTA blood sample]],  [[fluoride blood sample]],  [[inadequate phosphate intake]],  [[old blood samples]],  [[oxalate blood sample]]
|bgcolor="Beige"| [[Alcohol]],  [[amyloidosis]],  [[citrate|citrated blood sample]],  [[EDTA |EDTA blood sample]],  [[fluoride|fluoride treated blood sample]],  [[phosphate|inadequate phosphate intake]],  [[blood|old blood samples]],  [[oxalate|oxalate blood sample]]
|-
|-
|}
|}
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*[[Atherosclerotic heart disease]]
*[[Atherosclerotic heart disease]]
*[[Atopic dermatitis]]
*[[Atopic dermatitis]]
*[[Chronic myelogenous leukemia | Atypical chronic myelogenous leukemia]]
*[[Chronic myelogenous leukemia |Atypical chronic myelogenous leukemia]]
*[[Bacterial overgrowth]]
*[[Bacterial overgrowth]]
*[[Bariatric surgery]]
*[[Bariatric surgery]]
*[[Beta thalassemia]]
*[[Beta thalassemia]]
*[[Blind loops]]
*[[Blind loop syndrome]]
*[[Blood transfusion]]
*[[Blood transfusion]]
*[[Burns]]
*[[Burns]]
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*[[Chronic pancreatitis]]
*[[Chronic pancreatitis]]
*[[Chronic renal failure]]
*[[Chronic renal failure]]
*[[Citrated blood sample]]
*[[Citrate|Citrated blood sample]]
*[[Collagen vascular diseases]]
*[[Collagen vascular diseases]]
*[[Crohn's disease]]
*[[Crohn's disease]]
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*[[Erythroblastosis fetalis]]
*[[Erythroblastosis fetalis]]
*[[Essential thrombocythemia]]
*[[Essential thrombocythemia]]
{{col-break|width=33%}}
*[[Fanconi syndrome]]
*[[Fanconi syndrome]]
{{col-break|width=33%}}
*[[Fibromyalgia]]
*[[Fibromyalgia]]
*[[Diphyllobothrium | Fish tapeworm]]
*[[Diphyllobothrium |Fish tapeworm]]
*[[Fluoride blood sample]]
*[[Fluoride|Fluoride treated blood sample]]
*[[Gastrectomy]]
*[[Gastrectomy]]
*[[Giardia lamblia]]
*[[Giardia lamblia]]
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*[[Granulocyte colony-stimulating factor]]
*[[Granulocyte colony-stimulating factor]]
*[[Hepatic failure]]
*[[Hepatic failure]]
*[[Hereditary hyperphosphatasia]]
*[[Hyperphosphatemia|Hereditary hyperphosphatasia]]
*[[X-linked_hypophosphatemia | Hereditary hypophosphatemia]]
*[[X-linked_hypophosphatemia|Hereditary hypophosphatemia]]
*[[Autosomal dominant hypophosphatemic rickets | Hereditary hypophosphatemic rickets]]
*[[Autosomal dominant hypophosphatemic rickets|Hereditary hypophosphatemic rickets]]
*[[Hereditary vitamin D-resistant rickets]]
*[[Vitamin D resistant rickets|Hereditary vitamin D-resistant rickets]]
*[[Histoplasmosis | Histoplasmosis endocarditis]]
*[[Histoplasmosis|Histoplasmosis endocarditis]]
*[[HIV]]
*[[HIV]]
*[[Hookworm]]
*[[Hookworm]]
*[[Hungry bone syndrome]]
*[[Parathyroidectomy|Hungry bone syndrome]]
*[[Hyperparathyroidism]]
*[[Hyperparathyroidism]]
*[[Hypertension]]
*[[Hypertension]]
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*[[Hypoparathyroidism]]
*[[Hypoparathyroidism]]
*[[Hypophosphatemia]]
*[[Hypophosphatemia]]
*[[Hypothyroidism ]]
*[[Hypothyroidism]]
*[[Idiopathic hypereosinophilic syndrome]]
*[[Idiopathic hypereosinophilic syndrome]]
*[[Idiopathic thrombocytopenic purpura]]
*[[Idiopathic thrombocytopenic purpura]]
*[[Monoclonal gammopathy of undetermined significance | IgG monoclonal gammopathy]]
*[[Monoclonal gammopathy of undetermined significance | IgG monoclonal gammopathy]]
*[[Inadequate phosphate intake]]
*[[Phosphate|Inadequate phosphate intake]]
*[[Infectious mononucleosis]]
*[[Infectious mononucleosis]]
*[[Insulin]]
*[[Insulin]]
Line 486: Line 514:
*[[Mustard gas]]
*[[Mustard gas]]
*[[Myeloid metaplasia]]
*[[Myeloid metaplasia]]
*[[Myeloproliferative variants of hypereosinophilic syndrome]]
*[[Hypereosinophilic syndrome|Myeloproliferative variants of hypereosinophilic syndrome]]
*[[Neonatal infection]]<ref name="Sharma-1980">{{Cite journal  | last1 = Sharma | first1 = SC. | title = Leucocyte alkaline phosphatase in neonatal infections. | journal = Postgrad Med J | volume = 56 | issue = 657 | pages = 485-7 | month = Jul | year = 1980 | doi =  | PMID = 7443603 }}</ref>
*[[Infection|Neonatal infection]]<ref name="Sharma-1980">{{Cite journal  | last1 = Sharma | first1 = SC. | title = Leucocyte alkaline phosphatase in neonatal infections. | journal = Postgrad Med J | volume = 56 | issue = 657 | pages = 485-7 | month = Jul | year = 1980 | doi =  | PMID = 7443603 }}</ref>
*[[Niacin]]
*[[Niacin]]
{{col-break|width=33%}}
*[[Non-Hodgkin lymphoma]]
*[[Non-Hodgkin lymphoma]]
{{col-break|width=33%}}
*[[Blood|Old blood samples]]
*[[Old blood samples]]
*[[Oncogenic osteomalacia]]
*[[Oncogenic osteomalacia]]
*[[Osteoarthritis]]
*[[Osteoarthritis]]
*[[Osteomalacia]]
*[[Osteomalacia]]
*[[Oxalate blood sample]]
*[[Oxalate|Oxalate treated blood sample]]
*[[Paget's disease]]
*[[Paget's disease]]
*[[Panic attacks]]
*[[Panic attacks]]
*[[Paroxysmal nocturnal hemoglobinuria]]
*[[Paroxysmal nocturnal hemoglobinuria]]
*[[Pernicious anemia]]
*[[Pernicious anemia]]
*[[Post renal transplant]]
*[[Bile acid malabsorption|Primary bile acid diarrhea]]
*[[Primary bile acid diarrhea]]
*[[Myelofibrosis | Primary myelofibrosis]]
*[[Myelofibrosis | Primary myelofibrosis]]
*[[Radiation enteritis]]
*[[Radiation enteritis]]
*[[Recurrent neutropenia]]
*[[Neutropenia|Recurrent neutropenia]]
*[[Refeeding syndrome]]
*[[Refeeding syndrome]]
*[[Refractory anemia with ringed sideroblasts]]
*[[Thrombocytopenia | Refractory thrombocytopenia]]
*[[Thrombocytopenia | Refractory thrombocytopenia ]]
*[[Respiratory alkalosis]]
*[[Respiratory alkalosis]]
*[[Renal transplant]]
*[[Rheumatoid arthritis]]
*[[Rheumatoid arthritis]]
*[[Roundworm ]]
*[[Roundworm]]
*[[Salicylate ]]
*[[Salicylate]]
*[[Sarcoidosis]]
*[[Sarcoidosis]]
*[[Short bowel syndrome]]
*[[Short bowel syndrome]]
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*[[Sideroachrestic anemia]]
*[[Sideroachrestic anemia]]
*[[Sideroblastic anemia]]
*[[Sideroblastic anemia]]
*[[Subacute myeloid leukemia]]
*[[Myeloid leukemia|Subacute myeloid leukemia]]
*[[Sucrose intolerance]]
*[[Sucrose intolerance]]
*[[corticosteroids | Systemic corticosteroids]]
*[[Corticosteroids| Systemic corticosteroids]]
*[[Systemic lupus erythematosus]]
*[[Systemic lupus erythematosus]]
*[[Systemic sclerosis]]
*[[Systemic sclerosis]]
*[[Terbutaline]]
*[[Terbutaline]]
*[[ganglioneuroma | Thoracic ganglioneuroma]]
*[[ganglioneuroma| Thoracic ganglioneuroma]]
*[[Thrombocytopenic purpura]]
*[[Thrombocytopenic purpura]]
*[[Traveller's diarrhoea]]
*[[Traveller's diarrhoea]]
*[[Tricuspid atresia]]
*[[Tricuspid atresia]]
*[[Trilineage dysplasia]]
*[[Dysplasia|Trilineage dysplasia]]
*[[Tropical sprue]]
*[[Tropical sprue]]
*[[Uremia]]
*[[Uremia]]
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Latest revision as of 14:35, 20 August 2013

WikiDoc Resources for Leukocyte alkaline phosphatase

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vendhan Ramanujam M.B.B.S [2]

Synonyms and keywords: LAP

Overview

Leukocyte alkaline phosphatase is an enzyme found within white blood cells. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in polycythemia vera, essential thrombocytosis, primary myelofibrosis and leukemoid reaction. Lower levels are found in chronic myelogenous leukemia, aplastic anemia, paroxysmal nocturnal hemoglobinuria and acute myelogenous leukemia.

Causes of Increased Leukocyte alkaline phosphatase

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Giant cell arteritis, hemorrhagic shock, ischemic colitis, myocardial infarction, pericarditis, subacute endocarditis, vasculitis
Chemical/Poisoning Camphor, lead, lithium, mercury, pyrogallol, snakebite, turpentine
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect All-trans retinoic acid, arsphenamine, catecholamines, corticosteroids, dapsone, digitalis, neuroleptic malignant syndrome, oral contraceptives, phenacetin, quinidine, sulfa drugs
Ear Nose Throat Tonsillitis
Endocrine Cushing's disease, diabetes, diabetic coma, diabetic ketoacidosis
Environmental Heatstroke
Gastroenterologic Appendicitis, cholangitis, cholecystitis, gastric carcinoma, fulminant hepatic necrosis, ischemic colitis, liver abscess, liver fluke
Genetic Congenital asplenia, congenital neutropenia, Down syndrome, familial cold autoinflammatory syndrome, Fanconi anemia, hereditary neutrophilia, hyposplenism, Klinefelter syndrome, Kostmann syndrome, leukocyte adhesion factor deficiency, Pelger-Huet anomaly, rac mutation
Hematologic Acute lymphoblastic leukemia, acute myelogenous leukemia, agnogenic myeloid metaplasia, aplastic anemia, chronic neutrophilic leukemia, essential thrombocytopenia, Fanconi anemia, hairy cell leukemia, hemarthrosis, hemolysis, hemoperitoneum, hemorrhagic shock, Hodgkin's lymphoma, infectious mononucleosis, megaloblastic anemia, multiple myeloma, myelofibrosis, Pelger-Huet anomaly, polycythemia vera
Iatrogenic Blood transfusion, G-CSF, GM-CSF, post spleenectomy, vaccination
Infectious Disease Abscess, actinomyces, burkholderia mallei, cellulitis, cholangitis, cholecystitis, clostridium difficile, coccidioides immitis, escherichia coli, herpes zoster, infectious mononucleosis, klebsiella pneumoniae, liver abscess, liver fluke, malaria, mycobacterium tuberculosis, neisseria gonorrhoeae, osteomyelitis, otitis media, pelvic abscess, pelvic inflammatory disease, pertussis, plague, poliomyelitis, pseudomonas aeruginosa, pyelonephritis, rabies, rickettsia, salmonella typhi, salpingitis, sepsis, septic arthritis, smallpox, spirochetes, staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, streptococcus pyogenes, subacute endocarditis, tonsillitis, varicella, visceral larva migrans
Musculoskeletal/Orthopedic Septic arthritis
Neurologic Eclampsia, epidural hemorrhage, intracerebral hemorrhage, preeclampsia, subdural hemorrhage
Nutritional/Metabolic Diabetic coma, diabetic ketoacidosis, uremia
Obstetric/Gynecologic Cesarean delivery, eclampsia, pelvic inflammatory disease, preeclampsia, pregnancy, salpingitis
Oncologic Acute lymphoblastic leukemia, acute myelogenous leukemia, agnogenic myeloid metaplasia, bronchogenic carcinoma, gastric carcinoma, hairy cell leukemia, Hodgkin's lymphoma, paraneoplastic phenomenon, renal carcinoma, squamous cell carcinoma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Chronic anxiety, depression, panic disorders, posttraumatic stress disorder
Pulmonary Bronchogenic carcinoma, hemoperitoneum, klebsiella pneumoniae
Renal/Electrolyte Abscess, pyelonephritis, renal carcinoma, renal insufficiency
Rheumatology/Immunology/Allergy Acute gout, giant cell arteritis, rheumatic disease, rheumatoid arthritis, vasculitis
Sexual No underlying causes
Trauma Burns, epidural hemorrhage, hemarthrosis, hemoperitoneum, intracerebral hemorrhage, major tissue injury, subdural hemorrhage
Urologic No underlying causes
Miscellaneous Chronic idiopathic neutrophilia, cigarette smoking, emotional stress, insect venoms, physical stress, vigorous exercise

Causes in Alphabetical Order

Causes of Decreased Leukocyte Alkaline Phosphatase

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular Histoplasmosis endocarditis, tricuspid atresia
Chemical/Poisoning Mustard gas
Dental No underlying causes
Dermatologic Atopic dermatitis
Drug Side Effect Acetazolamide, albuterol, dopamine, epinephrine, glucagon, granulocyte colony-stimulating factor, insulin, salicylate, systemic corticosteroids, terbutaline
Ear Nose Throat No underlying causes
Endocrine Addison's disease, calcitonin, diabetes mellitus, hungry bone syndrome, hyperparathyroidism, hyperthyroidism, hypoparathyroidism, hypothyroidism
Environmental No underlying causes
Gastroenterologic Bacterial overgrowth, bariatric surgery, blind loop syndrome, carcinoid syndrome, carcinoma of pancreas, celiac disease, chronic pancreatitis, Crohn's disease, cystic fibrosis, eosinophilic gastroenteritis, fish tapeworm, giardia lamblia, hepatic failure, hookworm, intestinal tuberculosis, lactose intolerance, primary bile acid diarrhea, radiation enteritis, refeeding syndrome, roundworm, short bowel syndrome, sucrose intolerance, traveler's diarrhea, tropical sprue, Whipple's disease
Genetic Abetalipoproteinemia, beta thalassemia, cystic fibrosis, hereditary hyperphosphatasia, hereditary hypophosphatemia, hereditary hypophosphatemic rickets, hereditary vitamin D-resistant rickets, IgG monoclonal gammopathy, malignant histiocytosis, myeloproliferative variants of hypereosinophilic syndrome, paroxysmal nocturnal hemoglobinuria, primary myelofibrosis, trilineage dysplasia
Hematologic Acute myelogenous leukemia, aplastic anemia, atypical chronic myeloid leukemia, beta thalassemia, blood transfusion, chronic eosinophilic leukemia, chronic myelogenous leukemia, chronic myelomonocytic leukemia, erythroblastosis fetalis, essential thrombocythemia, fanconi syndrome, hemolysis, idiopathic hypereosinophilic syndrome, idiopathic thrombocytopenic purpura, iron deficiency anemia, myeloproliferative variants of hypereosinophilic syndrome, non-Hodgkin lymphoma, paroxysmal nocturnal hemoglobinuria, pernicious anemia, primary myelofibrosis, refractory thrombocytopenia, sickle cell disease, sideroachrestic anemia, sideroblastic anemia, thrombocytopenic purpura
Iatrogenic Bariatric surgery, blood transfusion, gastrectomy, vagotomy
Infectious Disease fish tapeworm, giardia lamblia, histoplasmosis endocarditis, HIV, hookworm, infectious mononucleosis, intestinal tuberculosis, roundworm, traveler's diarrhea
Musculoskeletal/Orthopedic degenerative arthritis, hereditary hypophosphatemic rickets, oncogenic osteomalacia, osteoarthritis, osteomalacia
Neurologic Dementia, thoracic ganglioneuroma
Nutritional/Metabolic Bacterial overgrowth, bariatric surgery, blind loop syndrome, celiac disease, chronic pancreatitis, chronic renal failure, Crohn's disease, gastrectomy, hereditary hypophosphatemia, hereditary vitamin D-resistant rickets, hungry bone syndrome, hypophosphatemia, primary bile acid diarrhea, radiation enteritis, refeeding syndrome, respiratory alkalosis, short bowel syndrome, sucrose intolerance, tropical sprue, Whipple's disease
Obstetric/Gynecologic No underlying causes
Oncologic Acute myelogenous leukemia, atypical chronic myelogenous leukemia, carcinoid syndrome, carcinoma of pancreas, chronic eosinophilic leukemia, chronic myelogenous leukemia, chronic myelomonocytic leukemia, malignant diseases, malignant lymphoma, non-Hodgkin lymphoma, oncogenic osteomalacia, thoracic ganglioneuroma
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric Chronic fatigue syndrome, dementia, panic attacks
Pulmonary Cystic fibrosis, respiratory alkalosis
Renal/Electrolyte Chronic renal failure, renal transplant
Rheumatology/Immunology/Allergy Blood transfusion, collagen vascular diseases, fibromyalgia, pernicious anemia, renal transplant, sarcoidosis, systemic lupus erythematosus, systemic sclerosis
Sexual No underlying causes
Trauma Burns
Urologic No underlying causes
Miscellaneous Alcohol, amyloidosis, citrated blood sample, EDTA blood sample, fluoride treated blood sample, inadequate phosphate intake, old blood samples, oxalate blood sample

Causes in Alphabetical Order

References

  1. ↑ Brook J, Dreisbach PB (1977). "Leukocyte alkaline phosphatase levels in multiple myeloma". J Lab Clin Med. 90 (1): 114–7. PMID 406335.
  2. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  3. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
  4. ↑ Gaasbeek, A.; Meinders, AE. (2005). "Hypophosphatemia: an update on its etiology and treatment". Am J Med. 118 (10): 1094–101. doi:10.1016/j.amjmed.2005.02.014. PMID 16194637. Unknown parameter |month= ignored (help)
  5. ↑ TANAKA, KR.; VALENTINE, WN.; FREDRICKS, RE. (1960). "Diseases or clinical conditions associated with low leukocyte alkaline phosphatase". N Engl J Med. 262: 912–8. doi:10.1056/NEJM196005052621804. PMID 13836802. Unknown parameter |month= ignored (help)
  6. ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  7. ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
  8. ↑ 8.0 8.1 Sharma, SC. (1980). "Leucocyte alkaline phosphatase in neonatal infections". Postgrad Med J. 56 (657): 485–7. PMID 7443603. Unknown parameter |month= ignored (help)
  9. ↑ 9.0 9.1 Lokich, JJ. (1977). "Leukocyte alkaline phosphatase activity in patients with malignant disease". Cancer. 40 (3): 1202–5. PMID 902237. Unknown parameter |month= ignored (help)

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