Immunoglobulin like domain smart00410

Associate Editor(s)-in-Chief: Henry A. Hoff

The United States National Library of Medicine (NLM) is a biomedical library in the United States as part of the National Institutes of Health that contains "hierarchical classifications of widely distributed protein domain families [and records] conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research."

"At the time of writing, the CDD version v3.17 is the live production version with 52,910 protein- and protein domain-models obtained from Pfam (1), SMART (2), the COGs collection (3), TIGRFAMS (4), the NCBI Protein Clusters collection (5), NCBIfam (6) and CDD’s in-house data curation effort (7)."

"SMART (Simple Modular Architecture Research Tool) is a web resource (http://smart.embl.de) for the identification and annotation of protein domains and the analysis of protein domain architectures."

Immunoglobulin supergene family

Main article: Immunoglobulin supergene family

The immunoglobulin supergene family is "the group of proteins that have immunoglobulin-like domains, including histocompatibility antigens, the T-cell antigen receptor, poly-IgR, and other proteins involved in the vertebrate immune response (17)."

Alpha-1-B glycoprotein variants

Gene ID: 1 A1BG alpha-1-B glycoprotein on 19q13.43: "The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins."

"𝛂₁B-glycoprotein(𝛂₁B) [...] consists of a single polypeptide chain N-linked to four glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues. [...] 𝛂₁B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond. [...] several domains of 𝛂₁B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 𝛂₁B [...] exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."

"Some of the domains of 𝛂₁B show significant homology to variable (V) and constant (C) regions of certain immunoglobulins. Likewise, there is statistically significant homology between 𝛂₁B and the secretory component (SC) of human IgA (15) and also with the extracellular portion of the rabbit receptor for transepithelial transport of polymeric immunoglobulins (IgA and IgM). Mostov et al. (16) have called the later protein the poly-Ig receptor or poly-IgR and have shown that it is the precursor of SC."

"𝛂₁B-glycoprotein(𝛂₁B) [...] consists of a single polypeptide chain N-linked to four glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues. [...] 𝛂₁B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond. [...] several domains of 𝛂₁B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 𝛂₁B [...] exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."

A1BG contains the immunoglobulin domain: cl11960 and three immunoglobulin-like domains: pfam13895, cd05751 and smart00410.

"Immunoglobulin (Ig) domain [cl11960] found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond."

"This domain [pfam13895] contains immunoglobulin-like domains."

"Ig1_LILR_KIR_like: [cd05751] domain similar to the first immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs) and Natural killer inhibitory receptors (KIRs). This group includes LILRB1 (or LIR-1), LILRA5 (or LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (or CD89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3,and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1 (LIR-1), LILRB2 (LIR-2), and LILRB3 (LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LIR-1 (LILRB1), and LIR-2 (LILRB2), show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1 (LIR-1), and LILRB2 (LIR-2), and two in the case of LILRB4 (LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst."

"IG domains [smart00410] that cannot be classified into one of IGv1, IGc1, IGc2, IG."

IGv: "This entry [SM00406] represents the V-set domains, which are Ig-like domains resembling the antibody variable domain. V-set domains are found in diverse protein families, including immunoglobulin light and heavy chains; in several T-cell receptors such as CD2 (Cluster of Differentiation 2), CD4, CD80, and CD86; in myelin membrane adhesion molecules; in junction adhesion molecules (JAM); in tyrosine-protein kinase receptors; and in the programmed cell death protein 1 (PD1)."

"There are 25606 IGv domains [SM00406] in 24468 proteins in SMART's nrdb database."

IGc1: "The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. The domains in Ig and Ig-like molecules are grouped into four types: V-set (variable; IPR013106), C1-set (constant-1; IPR003597), C2-set (constant-2; IPR008424) and I-set (intermediate; IPR013098) [(PUBMED:9417933)]. Structural studies have shown that these domains share a common core Greek-key beta-sandwich structure, with the types differing in the number of strands in the beta-sheets as well as in their sequence patterns [(PUBMED:15327963), (PUBMED:11377196)]." "Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. Ig-like domains are involved in a variety of functions, including cell-cell recognition, cell-surface receptors, muscle structure and the immune system [(PUBMED:10698639)]." "This entry [SM00407] represents C1-set domains, which are classical Ig-like domains resembling the antibody constant domain. C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules [(PUBMED:9597133), (PUBMED:12637770)], and in various T-cell receptors."

"There are 24638 IGc1 domains [SM00407] in 22657 proteins in SMART's nrdb database."

IGc2: "This entry [SM00408] represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules. It also includes proteins that are classified as unassigned proteinase inhibitors belonging to MEROPS inhibitor families I2, I17 and I43 [(PUBMED:14705960)]."

"There are 363480 IGc2 domains [SM00408] in 114582 proteins in SMART's nrdb database."

IG: "This subfamily [SM00409] includes:

• Cell surface receptors containing an immunoglobin domain.
• Killer cell inhibitory receptors.
• Oprin a snake venom metalloproteinase inhibitor from Didelphis marsupialis (Southern opossum) [(PUBMED:10779682)], which belongs to MEROPS inhibitor family I43, clan I- [(PUBMED:14705960)].
• Oprin homologues."

"There are 417572 IG domains [SM00409] in 173507 proteins in SMART's nrdb database."

"smart00410 is a member of the superfamily cl11960."

"There are 91644 IG_like domains [SM00410] in 55038 proteins in SMART's nrdb database."

Carcinoembryonic antigen gene family

Main article: Carcinoembryonic antigen gene family

Immunoglobulin superfamily genes

Main article: Immunoglobulin superfamily

Major histocompatibility complex genes

Main article: Major histocompatibility complex

Class I

Main article: MHC class I

Main article: Major histocompatibility complex class I gene family

Class II

Main article: MHC class II

Main article: Major histocompatibility complex class II gene family

Class III

Main article: MHC class III

Main article: Major histocompatibility complex class III gene family

Immunoglobulin domain genes

Main article: Immunoglobulin domain genes

Immunoglobulin receptor superfamily

Main article: Immunoglobulin receptor superfamily genes

Genes having immunoglobulin like domain smart00410

Number of genes = 299.

Gene ID: 1 see Immunoglobulin domain genes.

Gene ID: 176 is ACAN aggrecan on 15q26.1: "This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene."

1. NP_001126.3 aggrecan core protein isoform 1 precursor: "Transcript Variant: This variant (1) lacks three alternate in-frame exons in the 3' CDS, compared to variant 3. It encodes isoform 1, which lacks two internal segments, and is shorter, compared to isoform 3." Conserved Domains (5) summary: cd05900 Location: 43 → 154 Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan and smart00410 Location: 36 → 150 IG_like; Immunoglobulin like.
2. NP_001356197.1 aggrecan core protein isoform 3 precursor: "Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3)." Conserved Domains (8) summary: cd05900 Location: 43 → 154 Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan.
3. NP_037359.3 aggrecan core protein isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 3. It encodes isoform 2, which lacks an internal segment, and is shorter, compared to isoform 3." Conserved Domains (8) summary: cd05900 Location: 43 → 154 Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan.
4. XP_011519615.1 aggrecan core protein isoform X2, Conserved Domains (7) summary: cd05900 Location: 43 → 154 Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan and smart00410 Location: 36 → 150 IG_like; Immunoglobulin like.
5. XP_011519616.1 aggrecan core protein isoform X3, Conserved Domains (6) summary: cd05900 Location: 43 → 154 Ig_Aggrecan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), aggrecan and smart00410 Location: 36 → 150 IG_like; Immunoglobulin like.

Gene ID: 177 see Major histocompatibility complex class III gene family.

Gene ID: 214 see Carcinoembryonic antigen gene family.

Gene ID: 558 is AXL AXL receptor tyrosine kinase on 19q13.2: "The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene."

1. NP_001690.2 tyrosine-protein kinase receptor UFO isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1." Conserved Domains (7) summary: cd00096 Location: 53 → 126 Ig; Immunoglobulin domain, cd05749 Location: 141 → 222 Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs) and smart00410 Location: 145 → 223 IG_like; Immunoglobulin like.
2. NP_068713.2 tyrosine-protein kinase receptor UFO isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)." Conserved Domains (5) summary: cd05749 Location: 141 → 222 Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs) and cd00096 Location: 53 → 119 Ig; Immunoglobulin domain.

Gene ID: 634 see Carcinoembryonic antigen gene family.

Gene ID: 682 see Immunoglobulin supergene family.

Gene ID: 696 see Major histocompatibility complex class I gene family.

Gene ID: 924 see Immunoglobulin supergene family.

Gene ID: 925 is CD8A CD8a molecule on 2p11.2: "The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein."

1. NP_001139345.1 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor: "Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 3 encode the longer, membrane associated isoform (1)." Conserved Domains (2) summary: cd05720 Location: 31 → 133 Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain and smart00410 Location: 28 → 128 IG_like; Immunoglobulin like.
2. NP_001369627.1 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor.
3. NP_001759.3 T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longer, membrane associated isoform (1). Both variants 1 and 3 encode the same isoform (1)." Conserved Domains (2) summary: cd05720 Location: 31 → 133 Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain and smart00410 Location: 28 → 128 IG_like; Immunoglobulin like.
4. NP_741969.1 T-cell surface glycoprotein CD8 alpha chain isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) lacks an internal segment including the transmembrane domain compared to isoform 1, resulting in a secreted protein." Conserved Domains (2) summary: cd05720 Location: 31 → 133 Ig_CD8_alpha; Immunoglobulin (Ig) like domain of CD8 alpha chain and smart00410 Location: 28 → 128 IG_like; Immunoglobulin like.

Gene ID: 926 CD8B CD8b molecule on 2p11.2: "The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified."

1. NP_001171571.1 T-cell surface glycoprotein CD8 beta chain isoform 6 precursor: "Transcript Variant: This variant (6) lacks two exons in the 3' coding region, which results in a frameshift, compared to variant 2. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 2." Conserved Domains (2) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain and smart00410 Location: 26 → 134 IG_like; Immunoglobulin like.
2. NP_004922.1 T-cell surface glycoprotein CD8 beta chain isoform 5 precursor: "Transcript Variant: This variant (5), also known as M-1, differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 2." Conserved Domains (2) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain and smart00410 Location: 26 → 134 IG_like; Immunoglobulin like.
3. NP_742099.1 T-cell surface glycoprotein CD8 beta chain isoform 3 precursor: "Transcript Variant: This variant (3), also known as M-3, includes an alternate exon in the 3' coding region, which results in a frameshift compared to variant 2. The resulting membrane associated protein (isoform 3) is shorter and has a distinct C-terminus, compared to isoform 2." Conserved Domains (2) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain and smart00410 Location: 26 → 134 IG_like; Immunoglobulin like.
4. NP_742100.1 T-cell surface glycoprotein CD8 beta chain isoform 4 precursor: "Transcript Variant: This variant (4), also known as S-1, lacks an in-frame exon in the coding region, compared to variant 2. The resulting secreted protein (isoform 4) is shorter than isoform 2." Conserved Domains (2) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain and smart00410 Location: 26 → 134 IG_like; Immunoglobulin like.
5. NP_757362.1 T-cell surface glycoprotein CD8 beta chain isoform 2 precursor: "Transcript Variant: This variant (2) encodes the longest isoform (2)." Conserved Domains (1) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain.
6. XP_011531466.1 T-cell surface glycoprotein CD8 beta chain isoform X1, Conserved Domains (2) summary: cd07700 Location: 29 → 134 IgV_CD8_beta; Immunoglobulin (Ig) like domain of CD8 beta chain and smart00410 Location: 26 → 134 IG_like; Immunoglobulin like.

Gene ID: 930 see Immunoglobulin domain cl11960.

Gene ID: 933 see Carcinoembryonic antigen gene family.

Gene ID: 941 is CD80 CD80 molecule on 3q13.33: "The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy."

1. NP_005182.1 T-lymphocyte activation antigen CD80 precursor, Conserved Domains (2) summary: cd16083 Location: 142 → 232 IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80 and cd16086 Location: 35 → 139 IgV_CD80; Immunoglobulin variable domain (IgV) in CD80.

Gene ID: 942 see Immunoglobulin like domain pfam13895.

Gene ID: 945 is CD33 CD33 molecule on 19q13.41.

1. NP_001076087.1 myeloid cell surface antigen CD33 isoform 2: "Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2, also known as CD33m), compared to isoform 1." Conserved Domains (1) summary: pfam00047 Location: 19 → 100 ig; Immunoglobulin domain.
2. NP_001171079.1 myeloid cell surface antigen CD33 isoform 3 precursor: "Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1." Conserved Domains (3) summary: smart00410 Location: 26 → 128 IG_like; Immunoglobulin like, pfam00047 Location: 146 → 227 ig; Immunoglobulin domain and cl11960 Location: 23 → 139 Ig; Immunoglobulin domain.
3. NP_001763.3 myeloid cell surface antigen CD33 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as CD33M." Conserved Domains (3) summary: smart00410 Location: 26 → 128 IG_like; Immunoglobulin like, pfam00047 Location: 146 → 227 ig; Immunoglobulin domain and cl11960 Location: 23 → 139 Ig; Immunoglobulin domain.
4. XP_016882997.1 myeloid cell surface antigen CD33 isoform X1, Conserved Domains (3) summary: smart00410 Location: 80 → 182 IG_like; Immunoglobulin like, pfam00047 Location: 200 → 281 ig; Immunoglobulin domain and cl11960 Location: 77 → 193 Ig; Immunoglobulin domain.
5. XP_011525834.1 myeloid cell surface antigen CD33 isoform X3, Conserved Domains (3) summary: smart00410 Location: 26 → 128 IG_like; Immunoglobulin like, pfam00047 Location: 146 → 227ig; Immunoglobulin domain and cl11960 Location: 23 → 139 Ig; Immunoglobulin domain.
6. XP_011525833.1 myeloid cell surface antigen CD33 isoform X1, Conserved Domains (3) summary: smart00410 Location: 80 → 182 IG_like; Immunoglobulin like, pfam00047 Location: 200 → 281 ig; Immunoglobulin domain and cl11960 Location: 77 → 193 Ig; Immunoglobulin domain.

Gene ID: 946 is SIGLEC6 sialic acid binding Ig like lectin 6 on 19q13.41: "This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia."

1. NP_001171018.1 sialic acid-binding Ig-like lectin 6 isoform 4: "Transcript Variant: This variant (4) uses an alternate, in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1." Conserved Domains (3) summary: pfam07679 Location: 202 → 284 I-set; Immunoglobulin I-set domain, pfam13927 Location: 111 → 182 Ig_3; Immunoglobulin domain and cl11960 Location: 28 → 105 Ig; Immunoglobulin domain.
2. NP_001171019.1 sialic acid-binding Ig-like lectin 6 isoform 5 precursor: "Transcript Variant: This variant (5) uses an alternate, in-frame splice site and lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1." Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 265 → 347 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
3. NP_001171020.1 sialic acid-binding Ig-like lectin 6 isoform 6 precursor: "Transcript Variant: This variant (6) uses an alternate, in-frame splice site and lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1." Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 243 → 325 I-set; Immunoglobulin I-set domain, pfam13927 Location: 143 → 207 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
4. NP_001236.4 sialic acid-binding Ig-like lectin 6 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1)." Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 254 → 336 I-set; Immunoglobulin I-set domain pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
5. NP_942142.3 sialic acid-binding Ig-like lectin 6 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1." Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 238 → 320 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
6. NP_942143.3 sialic acid-binding Ig-like lectin 6 isoform 3 precursor: "Transcript Variant: This variant (3) lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1." Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 254 → 336 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
7. XP_011525838.1 sialic acid-binding Ig-like lectin 6 isoform X4, Conserved Domains (3) summary: pfam07679 Location: 229 → 311 I-set; Immunoglobulin I-set domain, pfam13927 Location: 111 → 182 Ig_3; Immunoglobulin domain and cl11960 Location: 28 → 105 Ig; Immunoglobulin domain.
8. XP_011525837.1 sialic acid-binding Ig-like lectin 6 isoform X3, Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 254 → 336 I-set; Immunoglobulin I-set domain, pfam13927 Location: 143 → 207 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
9. XP_011525840.1 sialic acid-binding Ig-like lectin 6 isoform X6, Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 265 → 347 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
10. XP_011525835.1 sialic acid-binding Ig-like lectin 6 isoform X1, Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 265 → 347 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
11. XP_011525839.1 sialic acid-binding Ig-like lectin 6 isoform X5, Conserved Domains (3) summary: pfam07679 Location: 218 → 300 I-set; Immunoglobulin I-set domain, pfam13927 Location: 111 → 182 Ig_3; Immunoglobulin domain and cl11960 Location: 28 → 105 Ig; Immunoglobulin domain.
12. XP_011525841.1 sialic acid-binding Ig-like lectin 6 isoform X8, Conserved Domains (3) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.
13. XP_011525836.1 sialic acid-binding Ig-like lectin 6 isoform X2, Conserved Domains (4) summary: smart00410 Location: 36 → 141 IG_like; Immunoglobulin like, pfam07679 Location: 265 → 347 I-set; Immunoglobulin I-set domain, pfam13927 Location: 147 → 218 Ig_3; Immunoglobulin domain and cl11960 Location: 31 → 141 Ig; Immunoglobulin domain.

Gene ID: 962 see Immunoglobulin like domain pfam13895.

Gene ID: 973 see Immunoglobulin receptor superfamily genes.

Gene ID: 974 see Immunoglobulin receptor superfamily genes.

Gene ID: 1048 see Carcinoembryonic antigen gene family.

Gene ID: 1088 see Carcinoembryonic antigen gene family.

Gene ID: 1089 see Carcinoembryonic antigen gene family.

Gene ID: 1272 see Immunoglobulin superfamily genes.

Gene ID: 1404

Gene ID: 1436

Gene ID: 1462

Gene ID: 1525

Gene ID: 1630 see Immunoglobulin receptor superfamily genes.

Gene ID: 1826 see Carcinoembryonic antigen gene family.

Gene ID: 2209 see Immunoglobulin receptor superfamily genes.

Gene ID: 2212 see Immunoglobulin receptor superfamily genes.

Gene ID: 2213 see Immunoglobulin receptor superfamily genes.

Gene ID: 2214 see Immunoglobulin receptor superfamily genes.

Gene ID: 2215

Gene ID: 2260 is FGFR1 fibroblast growth factor receptor 1: "The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized."

1. NP_001167534.1 fibroblast growth factor receptor 1 isoform 10 precursor: "Transcript Variant: This variant (10) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (10) lacks a 2-aa segment, compared to isoform 1." Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 163 → 247 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and cd05858 Location: 270 → 359 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
2. NP_001167535.1 fibroblast growth factor receptor 1 isoform 11 precursor: "Transcript Variant: This variant (11) includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (11) has a shorter and distinct N-terminus and lacks a 2-aa segment, compared to isoform 1." Conserved Domains (7) summary: cd04973 Location: 32 → 110 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 262 → 351 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 155 → 239 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 254 → 350 IG_like; Immunoglobulin like, and pfam07679 Location: 152 → 239 I-set; Immunoglobulin I-set domain.
3. NP_001167536.1 fibroblast growth factor receptor 1 isoform 2 precursor: "Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform.z" Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 268 → 357 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 260 → 356 IG_like; Immunoglobulin like, and pfam07679 Location: 158 → 245 I-set; Immunoglobulin I-set domain.
4. NP_001167537.1 fibroblast growth factor receptor 1 isoform 3 precursor: "Transcript Variant: This variant (12) represents use of an alternate promoter and 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform." Conserved Domains (6) summary: cd04974 Location: 181 → 270 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 74 → 158 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 173 → 269 IG_like; Immunoglobulin like, pfam07679 Location: 71 → 158 I-set; Immunoglobulin I-set domain.
5. NP_001167538.1 fibroblast growth factor receptor 1 isoform 14 precursor: "Transcript Variant: This variant (14) represents use of an alternate promoter and 5' UTR, includes an alternate exon, uses an alternate translation start site, and uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (14) lacks two internal segments, compared to isoform 1." Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 301 → 390 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 194 → 278 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 293 → 389 IG_like; Immunoglobulin like, pfam07679 Location: 191 → 278 I-set; Immunoglobulin I-set domain.
6. NP_001341296.1 fibroblast growth factor receptor 1 isoform 15 precursor, Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location:161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357, Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
7. NP_001341297.1 fibroblast growth factor receptor 1 isoform 16 precursor, Conserved Domains (3) summary: cd05857 Location: 72 → 156 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 179 → 268 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
8. NP_001341298.1 fibroblast growth factor receptor 1 isoform 17 precursor, Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, and cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
9. NP_001341299.1 fibroblast growth factor receptor 1 isoform 18 precursor, Conserved Domains (3) summary: cd05857 Location: 72 → 156 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 179 → 268 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
10. NP_056934.2 fibroblast growth factor receptor 1 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2), also known as isoform A, III, and the 3-Ig domain form, lacks a 2-aa segment, compared to isoform 1. Both variants 2 and 12 encode the same isoform." Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 268 → 357 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 260 → 356 IG_like; Immunoglobulin like, pfam07679 Location: 158 → 245 I-set; Immunoglobulin I-set domain.
11. NP_075593.1 fibroblast growth factor receptor 1 isoform 3 precursor: "Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3), also known as isoform Beta A1, II, H2, and the 2-Ig Domain+2 AA insert form, lacks the first Ig domain, compared to isoform 1. Both variants 3 and 13 encode the same isoform." Conserved Domains (6) summary: cd04974 Location: 181 → 270 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 74 → 158 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 173 → 269 IG_like; Immunoglobulin like, pfam07679 Location: 71 → 158 I-set; Immunoglobulin I-set domain.
12. NP_075594.1 fibroblast growth factor receptor 1 isoform 4 precursor: "Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses a different in-frame splice junction compared to variant 1. This variant encodes isoform 4, also known as isoform I, H3, and the 2-Ig Domain form, which is 91 aa shorter than isoform 1." Conserved Domains (6) summary: cd04974 Location: 179 → 268 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 72 → 156 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 171 → 267 IG_like; Immunoglobulin like, pfam07679 Location: 69 → 156 I-set; Immunoglobulin I-set domain.
13. NP_075598.2 fibroblast growth factor receptor 1 isoform 1 precursor: "Transcript Variant: This variant (1) encodes isoform 1, also known as isoform Alpha A1, IV and the 3-Ig domain+2 AA insert form." Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 270 → 359 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 163 → 247 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 262 → 358 IG_like; Immunoglobulin like, pfam07679 Location: 160 → 247 I-set; Immunoglobulin I-set domain.
14. XP_006716373.1 fibroblast growth factor receptor 1 isoform X18 Conserved Domains (6) summary: cd04974 Location: 181 → 270 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 74 → 158 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 173 → 269 IG_like; Immunoglobulin like, and pfam07679 Location: 71 → 158 I-set; Immunoglobulin I-set domain.
15. XP_006716366.1 fibroblast growth factor receptor 1 isoform X8, Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 270 → 359 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 163 → 247 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 262 → 358 IG_like; Immunoglobulin like, and pfam07679 Location: 160 → 247 I-set; Immunoglobulin I-set domain.
16. XP_016868710.1 fibroblast growth factor receptor 1 isoform X8, Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 270 → 359 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 163 → 247 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 262 → 358 IG_like; Immunoglobulin like, and pfam07679 Location: 160 → 247 I-set; Immunoglobulin I-set domain.
17. XP_006716370.1 fibroblast growth factor receptor 1 isoform X9, Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
18. XP_006716367.1 fibroblast growth factor receptor 1 isoform X8 Conserved Domains (7) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 270 → 359 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 163 → 247 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 262 → 358 IG_like; Immunoglobulin like, and pfam07679 Location: 160 → 247 I-set; Immunoglobulin I-set domain.
19. XP_006716377.1 fibroblast growth factor receptor 1 isoform X19, Conserved Domains (3) summary: cd05857 Location: 72 → 156 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 179 → 268 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
20. XP_006716374.1 fibroblast growth factor receptor 1 isoform X18, Conserved Domains (6) summary: cd04974 Location: 181 → 270 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 74 → 158 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 173 → 269 IG_like; Immunoglobulin like, and pfam07679 Location: 71 → 158 I-set; Immunoglobulin I-set domain.
21. XP_011542747.1 fibroblast growth factor receptor 1 isoform X3, Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 303 → 392 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 196 → 280 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 295 → 391 IG_like; Immunoglobulin like, pfam07679 Location: 193 → 280 I-set; Immunoglobulin I-set domain.
22. XP_011542745.1 fibroblast growth factor receptor 1 isoform X1, Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 303 → 392 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 196 → 280 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 295 → 391 IG_like; Immunoglobulin like, pfam07679 Location: 193 → 280 I-set; Immunoglobulin I-set domain.
23. XP_011542746.1 fibroblast growth factor receptor 1 isoform X2, Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 301 → 390 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 194 → 278 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 293 → 389 IG_like; Immunoglobulin like, pfam07679 Location: 191 → 278 I-set; Immunoglobulin I-set domain.
24. XP_011542751.1 fibroblast growth factor receptor 1 isoform X14, Conserved Domains (6) summary: cd04974 Location: 212 → 301 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 105 → 189 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 204 → 300 IG_like; Immunoglobulin like, pfam07679 Location: 102 → 189 I-set; Immunoglobulin I-set domain.
25. XP_011542750.1 fibroblast growth factor receptor 1 isoform X13, Conserved Domains (6) summary: cd04974 Location: 214 → 303 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 107 → 191 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 206 → 302 IG_like; Immunoglobulin like, pfam07679 Location: 104 → 191 I-set; Immunoglobulin I-set domain.
26. XP_006716375.1 fibroblast growth factor receptor 1 isoform X18, Conserved Domains (6) summary: cd04974 Location: 181 → 270 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 74 → 158 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 173 → 269 IG_like; Immunoglobulin like, pfam07679 Location: 71 → 158 I-set; Immunoglobulin I-set domain.
27. XP_011542753.1 fibroblast growth factor receptor 1 isoform X20, Conserved Domains (6) summary: cd04974 Location: 173 → 262 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 66 → 150 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 165 → 261 IG_like; Immunoglobulin like, pfam07679 Location: 63 → 150 I-set; Immunoglobulin I-set domain.
28. XP_024302865.1 fibroblast growth factor receptor 1 isoform X11, Conserved Domains (4) summary: cd04973 Location: 32 → 110 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 155 → 239 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 262 → 351 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
29. XP_016868713.1 fibroblast growth factor receptor 1 isoform X12, Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
30. XP_011542749.1 fibroblast growth factor receptor 1 isoform X6, Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 303 → 392 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 196 → 280, Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 295 → 391 IG_like; Immunoglobulin like, and pfam07679 Location:193 → 280 I-set; Immunoglobulin I-set domain.
31. XP_011542748.1 fibroblast growth factor receptor 1 isoform X5, Conserved Domains (7) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 303 → 392 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 196 → 280 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 295 → 391 IG_like; Immunoglobulin like, and pfam07679 Location: 193 → 280 I-set; Immunoglobulin I-set domain.
32. XP_011542752.1 fibroblast growth factor receptor 1 isoform X15, Conserved Domains (6) summary: cd04974 Location: 212 → 301 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 105 → 189 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 204 → 300 IG_like; Immunoglobulin like, and pfam07679 Location: 102 → 189 I-set; Immunoglobulin I-set domain.
33. XP_016868714.1 fibroblast growth factor receptor 1 isoform X12, Conserved Domains (4) summary: cd04973 Location: 40 → 118 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2).
34. XP_011542754.1 fibroblast growth factor receptor 1 isoform X24, Conserved Domains (5) summary: cd04973 Location: 73 → 151 Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd04974 Location: 301 → 387 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 194 → 278 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00410 Location: 293 → 387 IG_like; Immunoglobulin like, and pfam07679 Location: 191 → 278 I-set; Immunoglobulin I-set domain.

Gene ID: 2261 is FGFR3 fibroblast growth factor receptor 3 on 4p16.3: "This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia."

1. NP_000133.1 fibroblast growth factor receptor 3 isoform 1 precursor: "Transcript Variant: This variant (1) lacks an alternate coding exon and contains another alternate coding exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3." Conserved Domains (7) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 356 IG_like; Immunoglobulin like.
2. NP_001156685.1 fibroblast growth factor receptor 3 isoform 3 precursor: "Transcript Variant: This variant (3), also known as isoform IIIb, encodes the longest isoform (3)." Conserved Domains (7) summary: cd04974 Location: 268 → 356 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 355 IG_like; Immunoglobulin like.
3. NP_001341738.1 fibroblast growth factor receptor 3 isoform 4 precursor: "Transcript Variant: This variant (4) lacks an alternate coding exon, contains another alternate coding exon, and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3." Conserved Domains (4) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), and smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type.
4. NP_001341739.1 fibroblast growth factor receptor 3 isoform 5 precursor: "Transcript Variant: This variant (5) lacks two alternate coding exons, contains another alternate coding exon, and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (5) has multiple differences compared to isoform 3." Conserved Domains (4) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), and smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type.
5. NP_075254.1 fibroblast growth factor receptor 3 isoform 2 precursor: "Transcript Variant: This variant (2) lacks two alternate coding exons compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3." Conserved Domains (6) summary: cd04974 Location: 268 → 357 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, and smart00409 Location: 260 → 289 IG; Immunoglobulin.
6. XP_006713931.1 fibroblast growth factor receptor 3 isoform X1, Conserved Domains (7) summary: cd04974 Location: 268 → 356 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 355 IG_like; Immunoglobulin like.
7. XP_006713932.1 fibroblast growth factor receptor 3 isoform X2 Conserved Domains (7) summary: cd04974 Location: 268 → 356 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 355 IG_like; Immunoglobulin like.
8. XP_006713933.1 fibroblast growth factor receptor 3 isoform X3, Conserved Domains (7) summary: cd04974 Location: 268 → 356 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and 'smart00410 Location: 260 → 355 IG_like; Immunoglobulin like.
9. XP_006713934.1 fibroblast growth factor receptor 3 isoform X4 Conserved Domains (7) summary: cd04974 Location: 268 → 356 Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR), cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 355 IG_like; Immunoglobulin like.
10. XP_011511722.1 fibroblast growth factor receptor 3 isoform X5, Conserved Domains (7) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 356 IG_like; Immunoglobulin like.
11. XP_011511724.1 fibroblast growth factor receptor 3 isoform X6, Conserved Domains (7) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 356 IG_like; Immunoglobulin like.
12. XP_006713936.1 fibroblast growth factor receptor 3 isoform X7, Conserved Domains (7) summary: cd05857 Location: 161 → 245 Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor, cd05858 Location: 268 → 357 Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2), smart00408 Location: 53 → 110 IGc2; Immunoglobulin C-2 Type, smart00409 Location: 54 → 125 IG; Immunoglobulin, and smart00410 Location: 260 → 356 IG_like; Immunoglobulin like.

Gene ID: 2263 see Immunoglobulin domain cl11960.

Gene ID: 2264

Gene ID: 2321 see Immunoglobulin domain cl11960.

Gene ID: 2324 see Immunoglobulin like domain pfam13895.

Gene ID: 3084 see Immunoglobulin domain cl11960.

Gene ID: 3120 see Major histocompatibility complex class II gene family.

Gene ID: 3321 see Immunoglobulin supergene family.

Gene ID: 3339 see Immunoglobulin like domain pfam13895.

Gene ID: 3383 see Carcinoembryonic antigen gene family.

Gene ID: 3385 see Carcinoembryonic antigen gene family.

Gene ID: 3547 see Immunoglobulin supergene family.

Gene ID: 3554

Gene ID: 3570 is IL6R interleukin 6 receptor on 1q21.3: "This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9."

1. NP_000556.1 interleukin-6 receptor subunit alpha isoform 1 precursor, Conserved Domains (3) summary: smart00408 Location: 39 → 97 IGc2; Immunoglobulin C-2 Type.
2. NP_001193795.1 interleukin-6 receptor subunit alpha isoform 3 precursor, Conserved Domains (4) summary: smart00408 Location: 39 → 97 IGc2; Immunoglobulin C-2 Type, smart00410 Location: 33 → 110 IG_like; Immunoglobulin like.
3. NP_852004.1 interleukin-6 receptor subunit alpha isoform 2 precursor, Conserved Domains (3) summary: smart00408 Location: 39 → 97 IGc2; Immunoglobulin C-2 Type.
4. XP_005245196.1 interleukin-6 receptor subunit alpha isoform X6, Conserved Domains (4) summary: smart00408 Location: 39 → 97 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 33 → 110 IG_like; Immunoglobulin like.
5. XP_005245197.1 interleukin-6 receptor subunit alpha isoform X7, Conserved Domains (4) summary: smart00408 Location: 39 → 97 IGc2; Immunoglobulin C-2 Type, and smart00410 Location: 33 → 110 IG_like; Immunoglobulin like.

Gene ID: 3590

Gene ID: 3791 see Immunoglobulin like domain pfam13895.

Gene ID: 3805 see Immunoglobulin receptor superfamily genes.

Gene ID: 3811 see Immunoglobulin receptor superfamily genes.

Gene ID: 3812 see Immunoglobulin receptor superfamily genes.

Gene ID: 3815 is KIT KIT proto-oncogene, receptor tyrosine kinase on 4q12: "This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene."

1. NP_000213.1 mast/stem cell growth factor receptor Kit isoform 1 precursor: Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." Conserved Domains (6) summary: cd00096 Location: 426 → 505 Ig; Immunoglobulin domain, cd05860 Location: 311 → 411 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 307 IG_like; Immunoglobulin like, and pfam00047 Location: 216 → 305 ig; Immunoglobulin domain.
2. NP_001087241.1 mast/stem cell growth factor receptor Kit isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2)." Conserved Domains (6) summary: cd00096 Location:426 → 505, Ig; Immunoglobulin domain, cd05860 Location: 311 → 411 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 307 IG_like; Immunoglobulin like, and pfam00047 Location: 216 → 305 ig; Immunoglobulin domain.
3. XP_005265797.1 mast/stem cell growth factor receptor Kit isoform X1 Conserved Domains (6) summary: cd00096 Location: 427 → 506 Ig; Immunoglobulin domain, cd05860 Location: 312 → 412 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 308 IG_like; Immunoglobulin like, and pfam00047 Location: 216 → 306 ig; Immunoglobulin domain.
4. XP_005265798.1 mast/stem cell growth factor receptor Kit isoform X2 Conserved Domains (6) summary: cd00096 Location: 427 → 506 Ig; Immunoglobulin domain, cd05860 Location: 312 → 412 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 308 IG_like; Immunoglobulin like, pfam00047 Location: 216 → 306 ig; Immunoglobulin domain.
5. XP_005265799.1 mast/stem cell growth factor receptor Kit isoform X4 Conserved Domains (6) summary: cd00096 Location: 427 → 506 Ig; Immunoglobulin domain, cd05860 Location: 312 → 412 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 308 IG_like; Immunoglobulin like, and pfam00047 Location: 216 → 306 ig; Immunoglobulin domain.
6. XP_016863669.1 mast/stem cell growth factor receptor Kit isoform X6 Conserved Domains (6) summary: cd00096 Location: 426 → 505 Ig; Immunoglobulin domain, cd05860 Location: 311 → 411 Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR), smart00410 Location: 220 → 307 IG_like; Immunoglobulin like, and pfam00047 Location: 216 → 305 ig; Immunoglobulin domain.

Gene ID: 3897 see Carcinoembryonic antigen gene family.

Gene ID: 3902

Gene ID: 3904 see Immunoglobulin receptor superfamily genes.

Gene ID: 4045

Gene ID: 4059 see Carcinoembryonic antigen gene family.

Gene ID: 4099

Gene ID: 4340

Gene ID: 4359

Gene ID: 4604

Gene ID: 4606

Gene ID: 4607

Gene ID: 4680 see Carcinoembryonic antigen gene family.

Gene ID: 4684 see Carcinoembryonic antigen gene family.

Gene ID: 4685 see Carcinoembryonic antigen gene family.

Gene ID: 4756

Gene ID: 4868

Gene ID: 4897 see Carcinoembryonic antigen gene family.

Gene ID: 4916 is NTRK3 neurotrophic receptor tyrosine kinase 3 on 15q25.3: "This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene."

1. NP_001007157.1 NT-3 growth factor receptor isoform c precursor: "Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus and is shorter than isoform a." Conserved Domains (5) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC.
2. NP_001012338.1 NT-3 growth factor receptor isoform a precursor: "Transcript Variant: This variant (1) encodes the longest isoform (a)." Conserved Domains (8) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
3. NP_001230030.1 NT-3 growth factor receptor isoform d precursor: "Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but lacks two alternate internal segments compared to isoform a." Conserved Domains (8) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
4. NP_001307063.1 NT-3 growth factor receptor isoform e precursor: "Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a." Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
5. NP_001307064.1 NT-3 growth factor receptor isoform f: "Transcript Variant: This variant (6) has multiple differences in the coding and non-coding regions, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform f) has a shorter N-terminus and a distinct C-terminus and is shorter than isoform a." Conserved Domains (7) summary: cd04971 Location: 221 → 298 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 113 → 203 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 120 → 203 IG_like; Immunoglobulin like.
6. NP_002521.2 NT-3 growth factor receptor isoform b precursor: "Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a." Conserved Domains (8) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
7. XP_016877729.1 NT-3 growth factor receptor isoform X1, Conserved Domains (8) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, smart00219 Location: 538 → 810 TyrKc; Tyrosine kinase, catalytic domain and smart00410 Location:218 → 301, IG_like; Immunoglobulin like.
8. XP_016877743.1 NT-3 growth factor receptor isoform X20, Conserved Domains (8) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
9. XP_024305701.1 NT-3 growth factor receptor isoform X6, Conserved Domains (6) summary: cd04971 Location: 221 → 298 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 113 → 203 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC.
10. XP_006720608.1 NT-3 growth factor receptor isoform X7, Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
11. XP_024305702.1 NT-3 growth factor receptor isoform X8, Conserved Domains (5) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC.
12. XP_024305704.1 NT-3 growth factor receptor isoform X13, Conserved Domains (5) summary: cd04971Location:221 → 298 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC and cd04972 Location: 113 → 203 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC.
13. XP_024305703.1 NT-3 growth factor receptor isoform X11, Conserved Domains (5) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC.
14. XP_006720611.1 NT-3 growth factor receptor isoform X12, Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
15. XP_006720613.1 NT-3 growth factor receptor isoform X15, Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
16. XP_006720612.1 NT-3 growth factor receptor isoform X14, Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.
17. XP_011519940.1 NT-3 growth factor receptor isoform X17, Conserved Domains (7) summary: cd04971 Location: 319 → 396 Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, cd04972 Location: 211 → 301 Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC, and smart00410 Location: 218 → 301 IG_like; Immunoglobulin like.

Gene ID: 4919

Gene ID: 4978 see Carcinoembryonic antigen gene family.

Gene ID: 5067

Gene ID: 5133 is PDCD1 programmed cell death 1 on 2q37.3: "This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases."

1. NP_005009.2 programmed cell death protein 1 precursor, Conserved Domains (1) summary: cd16088 Location: 35 → 144 IgV_PD1; Immunoglobulin (Ig)-like domain of Programmed cell Death 1 (PD1).
2. XP_006712636.1 programmed cell death protein 1 isoform X2, Conserved Domains (2) summary: smart00410 Location: 39 → 125 IG_like; Immunoglobulin like and pfam07686 Location: 38 → 127 V-set; Immunoglobulin V-set domain.

Gene ID: 5156 see Immunoglobulin domain cl11960.

Gene ID: 5157

Gene ID: 5159 see Immunoglobulin domain cl11960.

Gene ID: 5175 see Carcinoembryonic antigen gene family.

Gene ID: 5644

Gene ID: 5669

Gene ID: 5670

Gene ID: 5671

Gene ID: 5672

Gene ID: 5673

Gene ID: 5675

Gene ID: 5676

Gene ID: 5678

Gene ID: 5680

Gene ID: 5738

Gene ID: 5754

Gene ID: 5789

Gene ID: 5792

Gene ID: 5796

Gene ID: 5797

Gene ID: 5802

Gene ID: 5817

Gene ID: 5818

Gene ID: 5819

Gene ID: 6092

Gene ID: 6330

Gene ID: 6405 see Immunoglobulin domain genes.

Gene ID: 6614

Gene ID: 6900

Gene ID: 7075 see Immunoglobulin domain genes.

Gene ID: 7087 see Carcinoembryonic antigen gene family.

Gene ID: 7273 see Immunoglobulin like domain pfam13895.

Gene ID: 7301

Gene ID: 7412 see Carcinoembryonic antigen gene family.

Gene ID: 7441 see Immunoglobulin supergene family.

Gene ID: 7850

Gene ID: 8174 see Carcinoembryonic antigen gene family.

Gene ID: 8482 see Immunoglobulin domain genes.

Gene ID: 8736

Gene ID: 8778

Gene ID: 8808

Gene ID: 8809

Gene ID: 9019

Gene ID: 9103

Gene ID: 9172

Gene ID: 9173

Gene ID: 9214

Gene ID: 9308

Gene ID: 9398 see Immunoglobulin supergene family.

Gene ID: 9436

Gene ID: 9543 see Immunoglobulin supergene family.

Gene ID: 9848

Gene ID: 10261 see Immunoglobulin supergene family.

Gene ID: 10288 see Immunoglobulin receptor superfamily genes.

Gene ID: 10326

Gene ID: 10384 see Major histocompatibility complex class I gene family.

Gene ID: 10385 see Major histocompatibility complex class I gene family.

Gene ID: 10461

Gene ID: 10507 see Immunoglobulin domain genes.

Gene ID: 10666

Gene ID: 10752 see Carcinoembryonic antigen gene family.

Gene ID: 10859 see Immunoglobulin receptor superfamily genes.

Gene ID: 10892

Gene ID: 10990 see Immunoglobulin receptor superfamily genes.

Gene ID: 11006 see Immunoglobulin receptor superfamily genes.

Gene ID: 11024 see Immunoglobulin receptor superfamily genes.

Gene ID: 11026 see Immunoglobulin receptor superfamily genes.

Gene ID: 11027 see Immunoglobulin receptor superfamily genes.

Gene ID: 11055

Gene ID: 11118 see Major histocompatibility complex class I gene family.

Gene ID: 11119 see Major histocompatibility complex class I gene family.

Gene ID: 11120 see Major histocompatibility complex class I gene family.

Gene ID: 11141

Gene ID: 11148

Gene ID: 11314 see Immunoglobulin supergene family.

Gene ID: 11326 see Immunoglobulin domain genes.

Gene ID: 22997 see Immunoglobulin supergene family

Gene ID: 23105

Gene ID: 23114

Gene ID: 23363

Gene ID: 23547 see Immunoglobulin receptor superfamily genes.

Gene ID: 23705 see Carcinoembryonic antigen gene family.

Gene ID: 25878

Gene ID: 25945

Gene ID: 26103 see Immunoglobulin domain genes.

Gene ID: 26280

Gene ID: 27020

Gene ID: 27036

Gene ID: 27180

Gene ID: 27181

Gene ID: 27255

Gene ID: 29126 see Immunoglobulin domain cl11960.

Gene ID: 29992

Gene ID: 50848 see Carcinoembryonic antigen gene family.

Gene ID: 50863

Gene ID: 50937 see Carcinoembryonic antigen gene family.

Gene ID: 53942

Gene ID: 54209

Gene ID: 54210

Gene ID: 54538

Gene ID: 54549

Gene ID: 54621

Gene ID: 55080

Gene ID: 55243

Gene ID: 55423

Gene ID: 56244

Gene ID: 56253

Gene ID: 56884

Gene ID: 57188

Gene ID: 57453 see Carcinoembryonic antigen gene family.

Gene ID: 57463

Gene ID: 57549 see Immunoglobulin supergene family.

Gene ID: 57622

Gene ID: 57689

Gene ID: 57722

Gene ID: 57823

Gene ID: 57863 see Carcinoembryonic antigen gene family.

Gene ID: 58494 see Carcinoembryonic antigen gene family.

Gene ID: 63827

Gene ID: 79168 see Immunoglobulin domain genes.

Gene ID: 79368 see Immunoglobulin receptor superfamily genes.

Gene ID: 79414

Gene ID: 79679

Gene ID: 79827

Gene ID: 79908

Gene ID: 80380

Gene ID: 80381

Gene ID: 81607

Gene ID: 83416 see Immunoglobulin receptor superfamily genes.

Gene ID: 83417 see Immunoglobulin receptor superfamily genes.

Gene ID: 83700 see Carcinoembryonic antigen gene family.

Gene ID: 83872

Gene ID: 83953 see Immunoglobulin supergene family.

Gene ID: 84033

Gene ID: 84063

Gene ID: 84623

Gene ID: 84824

Gene ID: 84868 see Immunoglobulin receptor superfamily genes.

Gene ID: 84966 see Immunoglobulin supergene family.

Gene ID: 89790

Gene ID: 89858

Gene ID: 89932

Gene ID: 90273 see Carcinoembryonic antigen gene family.

Gene ID: 90952 see Carcinoembryonic antigen gene family.

Gene ID: 91156

Gene ID: 91653

Gene ID: 91937 is TIMD4 T cell immunoglobulin and mucin domain containing 4 on 5q33.3.

1. NP_001140198.1 T-cell immunoglobulin and mucin domain-containing protein 4 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1." Conserved Domains (2) summary: smart00410 Location: 27 → 115 IG_like; Immunoglobulin like and pfam07686 Location: 23 → 128 V-set; Immunoglobulin V-set domain.
2. NP_612388.2 T-cell immunoglobulin and mucin domain-containing protein 4 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." Conserved Domains (2) summary: smart00410 Location: 27 → 115 IG_like; Immunoglobulin like and pfam07686 Location: 23 → 128 V-set; Immunoglobulin V-set domain.

Gene ID: 92949

Gene ID: 114132

Gene ID: 114625

Gene ID: 114836

Gene ID: 115350 see Immunoglobulin receptor superfamily genes.

Gene ID: 115352 see Immunoglobulin receptor superfamily genes.

Gene ID: 115653 see Immunoglobulin receptor superfamily genes.

Gene ID: 115701

Gene ID: 120425 see Carcinoembryonic antigen gene family.

Gene ID: 124599

Gene ID: 125931 see Carcinoembryonic antigen gene family.

Gene ID: 126014 see Immunoglobulin receptor superfamily genes.

Gene ID: 126259 see Immunoglobulin domain genes.

Gene ID: 127294

Gene ID: 127943

Gene ID: 128646

Gene ID: 133418

Gene ID: 140885 see Immunoglobulin supergene family.

Gene ID: 145864

Gene ID: 146722 see Immunoglobulin supergene family.

Gene ID: 146894

Gene ID: 147645

Gene ID: 147650

Gene ID: 150084 see Immunoglobulin supergene family.

Gene ID: 151888

Gene ID: 152330

Gene ID: 152404 see Immunoglobulin supergene family.

Gene ID: 153579

Gene ID: 161357

Gene ID: 166647

Gene ID: 196264

Gene ID: 199731 see Carcinoembryonic antigen gene family.

Gene ID: 220296 see Carcinoembryonic antigen gene family.

Gene ID: 221395

Gene ID: 222008

Gene ID: 223117 see Immunoglobulin domain genes.

Gene ID: 253559 see Carcinoembryonic antigen gene family.

Gene ID: 256158

Gene ID: 257194

Gene ID: 259197 see Major histocompatibility complex class III gene family.

Gene ID: 266727

Gene ID: 283284 see Immunoglobulin supergene family.

Gene ID: 283659

Gene ID: 284415

Gene ID: 284759

Gene ID: 285313 see Immunoglobulin supergene family.

Gene ID: 285852

Gene ID: 338667

Gene ID: 339398 see Immunoglobulin domain genes.

Gene ID: 340547 see Carcinoembryonic antigen gene family.

Gene ID: 342510

Gene ID: 342865

Gene ID: 343263

Gene ID: 343413 see Immunoglobulin receptor superfamily genes.

Gene ID: 345193 see Immunoglobulin domain genes.

Gene ID: 374383

Gene ID: 386724

Gene ID: 387804

Gene ID: 388364 is TMIGD1 transmembrane and immunoglobulin domain containing 1 on 17q11.2.

1. NP_001306871.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor: "Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1." Conserved Domains (2) summary: cd00096 Location: 139 → 209 Ig; Immunoglobulin domain and smart00410 Location: 131 → 212 IG_like; Immunoglobulin like.
2. NP_996663.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 1 precursor: "Transcript Variant: This variant (1) encodes the longer isoform (1)." Conserved Domains (2) summary: smart00410 Location: 131 → 212 IG_like; Immunoglobulin like.

Gene ID: 388551 see Carcinoembryonic antigen gene family.

Gene ID: 391123 is VSIG8 V-set and immunoglobulin domain containing 8 on 1q23.2.

1. NP_001013683.1 V-set and immunoglobulin domain-containing protein 8 precursor. smart00410 Location: 160 → 256 IG_like; Immunoglobulin like and pfam07686 Location: 35 → 142 V-set; Immunoglobulin V-set domain.

Gene ID: 400709

Gene ID: 440533

Gene ID: 441381

Gene ID: 441864

Gene ID: 553128 see Immunoglobulin receptor superfamily genes.

Gene ID: 729767 see Carcinoembryonic antigen gene family.

Gene ID: 100049587

Gene ID: 100130520

Gene ID: 100131439

Gene ID: 102723407

Gene ID: 102724971

Gene ID: 102725035

Gene ID: 107987425

Hypotheses

1. Downstream core promoters may work as transcription factors even as their complements or inverses.
2. In addition to the DNA binding sequences listed above, the transcription factors that can open up and attach through the local epigenome need to be known and specified.
3. The function of A1BG is the same as other immunoglobulin genes possessing the immunoglobulin domain cl11960 and/or any of three immunoglobulin-like domains: pfam13895, cd05751 and smart00410 in the order and nucleotide sequence: cd05751 Location: 401 → 493, smart00410 Location: 218 → 280, pfam13895 Location: 210 → 301 and cl11960 Location: 28 → 110.
4. More than one human gene or variant has all four: cd05751, cl11960, pfam13895 and smart00410.

See also

• Alpha-1-B glycoprotein
• Immunoglobulin like domain cd05751
• Immunoglobulin like domain pfam13895
• Immunoglobulin domain cl11960
• Nuclear factor gene transcriptions
• SCAN domain

External links

• GenomeNet KEGG database
• Home - Gene - NCBI
• NCBI All Databases Search
• NCBI Site Search

{{Phosphate biochemistry}}Template:Sisterlinks