Differentiating Antiphospholipid syndrome from other diseases: Difference between revisions
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![[HELLP syndrome|HELLP]] | ![[HELLP syndrome|HELLP]] | ||
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! colspan="2" |[[Paroxysmal nocturnal hemoglobinuria|Paroxysmal nocturnal hemoglobinuria (PNH)]] | ! colspan="2" |[[Paroxysmal nocturnal hemoglobinuria|Paroxysmal nocturnal hemoglobinuria (PNH)]] | ||
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!+/- | |||
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! | ![[Anemia]], [[Reticulocyte|reticulocytosis]], | ||
Increased [[lactate]] [[dehydrogenase]] (LDH) and [[bilirubin]] | |||
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!Direct [[Coombs test|antiglobulin]] (Coombs) testing (DAT) | |||
! | !Increased [[haptoglobin]] | ||
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! | !Bone marrow biopsy shows normocellular or hypercellular bone marrow with [[Red blood cell|erythroid]] [[hyperplasia]] | ||
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!Splenomegaly | |||
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!↑WBCs, predominantly neutrophils | |||
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! | !Philedelphia chromosome by PCR or BCR/ABL by FISH | ||
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Revision as of 20:21, 26 April 2018
Antiphospholipid syndrome Microchapters |
Differentiating Antiphospholipid syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
Antiphospholipid syndrome should be differentiated from conditions such as hemolytic uremic syndrome-thrombotic thrombocytopenic purpura (HUS-TTP), disseminated intravascular coagulation (DIC), paroxysmal nocturnal hemoglobinuria, SLE, HELLP syndrome and other myeloproliferative diseases.
Differentiating Antiphospholipid antibody syndrome from other Diseases
- Hemolytic uremic syndrome-Thrombotic thrombocytopenic purpura (HUS-TTP)
- Disseminated Intravascular Coagulation (DIC)
- paroxysmal nocturnal hemoglobinuria
- SLE
- HELLP syndrome
- Myeloproliferative diseases
Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.