Calcitriol: Difference between revisions

Calcitriol is the active form of vitamin D, normally made in the kidney.^[1]^[2]^[3] It is also known as 1,25-dihydroxycholecalciferol. It is a hormone which binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes.^[4] Calcitriol increases blood calcium (Ca²⁺) mainly by increasing the uptake of calcium from the intestines.^[5]

References

↑ Plum LA, DeLuca HF (December 2010). "Vitamin D, disease and therapeutic opportunities". Nature Reviews. Drug Discovery. 9 (12): 941–955. doi:10.1038/nrd3318. PMID 21119732.
↑ Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006.
↑ "Office of Dietary Supplements - Vitamin D". ods.od.nih.gov. 9 October 2020. Retrieved 31 October 2020.
↑ Norman AW (August 2008). "From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health". The American Journal of Clinical Nutrition. 88 (2): 491S–499S. doi:10.1093/ajcn/88.2.491S. PMID 18689389.
↑ "Calcitriol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 9 April 2019.

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@@ Line 1: / Line 1: @@
 {{Details0|Calcitriol (injection)}}
 {{Details0|Calcitriol (oral)}}
+{{Details0|Calcitriol (topical)}}
+'''Calcitriol''' is the active form of [[vitamin D]], normally made in the [[kidney]].<ref>{{cite journal | author = Plum LA, DeLuca HF | title = Vitamin D, disease and therapeutic opportunities | journal = Nature Reviews. Drug Discovery | volume = 9 | issue = 12 | pages = 941–955 | date = December 2010 | pmid = 21119732 | doi = 10.1038/nrd3318 }}</ref><ref>{{cite book |title=Encyclopedia of Endocrine Diseases |date=2018 |publisher=Academic Press |isbn=9780128122006 |page=344 |url=https://books.google.com/books?id=nVh7DwAAQBAJ&pg=RA4-PA344 }}</ref><ref name="NIH-ODS-2020">{{cite web |title=Office of Dietary Supplements - Vitamin D |url=https://ods.od.nih.gov/factsheets/VitaminD-HealthProfessional/ |website=ods.od.nih.gov |date=9 October 2020 |accessdate=31 October 2020 }}</ref> It is also known as '''1,25-dihydroxycholecalciferol'''. It is a [[hormone]] which binds to and activates the [[vitamin D receptor]] in the nucleus of the cell, which then increases the expression of many genes.<ref name="Norman_2008">{{cite journal | author = Norman AW | title = From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health | journal = The American Journal of Clinical Nutrition | volume = 88 | issue = 2 | pages = 491S–499S | date = August 2008 | pmid = 18689389 | doi = 10.1093/ajcn/88.2.491S }}</ref> Calcitriol increases blood [[Calcium in biology|calcium]] (Ca<sup>2+</sup>) mainly by increasing the uptake of calcium from the [[intestines]].<ref name=AHFS2019>{{cite web |title=Calcitriol Monograph for Professionals |url=https://www.drugs.com/monograph/calcitriol.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=9 April 2019 }}</ref>
-{{Details0|Calcitriol (topical)}}
+== References ==
+{{Reflist}}
+==External links==
+{{Gene project}}

Calcitriol: Difference between revisions

Latest revision as of 18:17, 30 March 2023

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