Abf1 regulatory factor gene transcriptions

Associate Editor(s)-in-Chief: Henry A. Hoff

Human genes

Gene ID: 9242 is MSC musculin on 8q13.3 aka ABF1; MYOR; ABF-1; bHLHa22: "The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway."^[1]

Consensus sequences

Specific "sequences considered as exact Abf1 motif occurrences": CGTNNNNNACGA(C/T), CGTNNNNNA(C/T)GAC, CGTNNNNNA(C/T)GA(C/T), CGTNNNNN(A/G)(C/T)GA(C/T).^[2]

Hypotheses

A1BG has no Abf1 regulatory factors in either promoter.
A1BG is not transcribed by an Abf1 regulatory factor.
Abf1 regulatory factor does not participate in the transcription of A1BG.

Samplings

Copying a consensus Abf1 regulatory factor: 5'-CGTNNNNNACGAT-3' and putting the sequence in "⌘F" locates 2 to 5 of this sequence in the ZSCAN22 to A1BG direction, and none between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence 5'-AAAAAAAA-3' (starting with SuccessablesAAA.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand in the negative direction (from ZSCAN22 to A1BG) is SuccessablesAAA--.bas, looking for 5'-AAAAAAAA-3', 0.
negative strand in the positive direction (from ZNF497 to A1BG) is SuccessablesAAA-+.bas, looking for 5'-AAAAAAAA-3', 0.
positive strand, negative direction is SuccessablesAAA+-.bas, looking for 5'-AAAAAAAA-3', 0.
positive strand, positive direction is SuccessablesAAA++.bas, looking for 5'-AAAAAAAA-3', 0.
complement, negative strand, negative direction is SuccessablesAAAc--.bas, looking for 5'-TTTTTTTT-3', 0.
complement, negative strand, positive direction is SuccessablesAAAc-+.bas, looking for 5'-TTTTTTTT-3', 0.
complement, positive strand, negative direction is SuccessablesAAAc+-.bas, looking for 5'-TTTTTTTT-3', 0.
complement, positive strand, positive direction is SuccessablesAAAc++.bas, looking for 5'-TTTTTTTT-3', 0.
inverse complement, negative strand, negative direction is SuccessablesAAAci--.bas, looking for 5'-TTTTTTTT-3', 0.
inverse complement, negative strand, positive direction is SuccessablesAAAci-+.bas, looking for 5'-TTTTTTTT-3', 0.
inverse complement, positive strand, negative direction is SuccessablesAAAci+-.bas, looking for 5'-TTTTTTTT-3', 0.
inverse complement, positive strand, positive direction is SuccessablesAAAci++.bas, looking for 5'-TTTTTTTT-3', 0.
inverse negative strand, negative direction is SuccessablesAAAi--.bas, looking for 5'-AAAAAAAA-3', 0.
inverse negative strand, positive direction is SuccessablesAAAi-+.bas, looking for 5'-AAAAAAAA-3', 0.
inverse positive strand, negative direction is SuccessablesAAAi+-.bas, looking for 5'-AAAAAAAA-3', 0.
inverse positive strand, positive direction is SuccessablesAAAi++.bas, looking for 5'-AAAAAAAA-3', 0.

Core promoters

Proximal promoters

Distal promoters

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

References

↑ RefSeq (July 2008). "MSC musculin [ Homo sapiens (human) ]". 8600 Rockville Pike, Bethesda MD, 20894 USA: National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 10 October 2020.
↑ Matthew J. Rossi, William K.M. Lai and B. Franklin Pugh (21 March 2018). "Genome-wide determinants of sequence-specific DNA binding of general regulatory factors". Genome Research. 28: 497–508. doi:10.1101/gr.229518.117. PMID 29563167. Retrieved 31 August 2020.

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