Leukocyte alkaline phosphatase: Difference between revisions
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| '''Hematologic''' | | '''Hematologic''' | ||
|bgcolor="Beige"| [[Acute myelogenous leukemia]], [[aplastic anemia]], [[ | |bgcolor="Beige"| [[Acute myelogenous leukemia]], [[aplastic anemia]], [[Chronic myelogenous leukemia | atypical chronic myeloid leukemia ]], [[beta thalassemia ]], [[blood transfusion ]], [[chronic eosinophilic leukemia]], [[chronic myelogenous leukemia]], [[chronic myelomonocytic leukemia]], [[erythroblastosis fetalis]], [[essential thrombocythemia]], [[fanconi syndrome]], [[hemolysis]], [[idiopathic hypereosinophilic syndrome]], [[idiopathic thrombocytopenic purpura]], [[iron deficiency anemia]], [[myeloproliferative variants of hypereosinophilic sundrome]], [[Non-Hodgkin lymphoma]], [[paroxysmal nocturnal hemoglobinuria]], [[pernicious anemia]], [[Myelofibrosis | primary myelofibrosis]], [[refractory anemia with ringed sideroblasts]], [[refractory thrombocytopenia ]], [[sickle cell disease]], [[sideroachrestic anemia]], [[sideroblastic anemia]], [[thrombocytopenic purpura]] | ||
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| '''Nutritional/Metabolic''' | | '''Nutritional/Metabolic''' | ||
|bgcolor="Beige"| [[ | |bgcolor="Beige"| [[Bacterial overgrowth]], [[bariatric surgery ]], [[blind loops]], [[celiac disease]], [[chronic pancreatitis]], [[chronic renal failure]], [[Crohn's disease]], [[gastrectomy]], [[X-linked_hypophosphatemia | Hereditary hypophosphatemia]], [[hereditary vitamin D-resistant rickets]], [[hungry bone syndrome]], [[hypophosphatemia]], [[primary bile acid diarrhea]], [[radiation enteritis]], [[refeeding syndrome]], [[Respiratory alkalosis | respiratory alkalosis]], [[short bowel syndrome]], [[sucrose intolerance]], [[tropical sprue]], [[Whipple's disease]] | ||
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| '''Oncologic''' | | '''Oncologic''' | ||
|bgcolor="Beige"| [[Acute myelogenous leukemia]], [[atypical chronic | |bgcolor="Beige"| [[Acute myelogenous leukemia]], [[Chronic myelogenous leukemia | atypical chronic myelogenous leukemia ]], [[carcinoid syndrome]], [[carcinoma of pancreas]], [[chronic eosinophilic leukemia]], [[chronic myelogenous leukemia]], [[chronic myelomonocytic leukemia]], [[malignant diseases]], [[malignant lymphoma]], [[Non-Hodgkin lymphoma]], [[oncogenic osteomalacia]], [[ganglioneuroma | Thoracic ganglioneuroma]] | ||
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| '''Pulmonary''' | | '''Pulmonary''' | ||
|bgcolor="Beige"| [[ | |bgcolor="Beige"| [[Cystic fibrosis]], [[Respiratory alkalosis | respiratory alkalosis]] | ||
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Revision as of 15:15, 18 July 2013
Leukocyte alkaline phosphatase |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Vendhan Ramanujam M.B.B.S [2]
Synonyms and keywords: LAP
Overview
Leukocyte alkaline phosphatase is an enzyme found within white blood cells. The blood level of leukocyte alkaline phosphatase is measured in order to help in the diagnosis of certain conditions. Higher levels of the enzyme are seen in polycythemia vera, essential thrombocytosis, primary myelofibrosis and leukemoid reaction. Lower levels are found in chronic myelogenous leukemia, aplastic anemia, paroxysmal nocturnal hemoglobinuria and acute myelogenous leukemia.
Causes of Increased Leukocyte Alkaline Phosphatase
Common Causes
- Acute leukemia
- Essential thrombocytosis
- Leukemoid reaction
- Malignant lymphomas
- Megaloblastic anemia
- Multiple Myeloma[1]
- Myelofibrosis
- Polycythemia Vera
- Solid tumors
- Tissue necrosis[2][3]
Causes by Organ System
Causes in Alphabetical Order
Causes of Decreased Leukocyte Alkaline Phosphatase
Common Causes
- Aplastic anemia
- Chronic Myelogenous Leukemia
- Hypophosphatemia[4]
- Iron deficiency anemia
- Paroxysmal nocturnal hemoglobinuria
- Systemic lupus erythematosus[4][5][6][7][8][9]
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Brook J, Dreisbach PB (1977). "Leukocyte alkaline phosphatase levels in multiple myeloma". J Lab Clin Med. 90 (1): 114–7. PMID 406335.
- ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
- ↑ 4.0 4.1 Gaasbeek, A.; Meinders, AE. (2005). "Hypophosphatemia: an update on its etiology and treatment". Am J Med. 118 (10): 1094–101. doi:10.1016/j.amjmed.2005.02.014. PMID 16194637. Unknown parameter
|month=
ignored (help) - ↑ TANAKA, KR.; VALENTINE, WN.; FREDRICKS, RE. (1960). "Diseases or clinical conditions associated with low leukocyte alkaline phosphatase". N Engl J Med. 262: 912–8. doi:10.1056/NEJM196005052621804. PMID 13836802. Unknown parameter
|month=
ignored (help) - ↑ Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
- ↑ Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X
- ↑ 8.0 8.1 Sharma, SC. (1980). "Leucocyte alkaline phosphatase in neonatal infections". Postgrad Med J. 56 (657): 485–7. PMID 7443603. Unknown parameter
|month=
ignored (help) - ↑ 9.0 9.1 Lokich, JJ. (1977). "Leukocyte alkaline phosphatase activity in patients with malignant disease". Cancer. 40 (3): 1202–5. PMID 902237. Unknown parameter
|month=
ignored (help)