Squamous cell carcinoma of the skin: Difference between revisions

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==[[Squamous cell carcinoma physical examination|Physical Examination]]==
==[[Squamous cell carcinoma physical examination|Physical Examination]]==
===Esophagus===
[[Esophageal cancer]] may be due to either squamous cell carcinoma (ESCC) or [[adenocarcinoma]] (EAC). SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach. [[Dysphagia]] (difficulty swallowing, solids worse than liquids) and [[odynophagia]] are common initial symptoms. If the disease is localized, [[esophagectomy]] may offer the possibility of a cure. If the disease has spread, [[chemotherapy]] and radiotherapy are commonly used.
====Penis====
When squamous cell carcinoma in situ (Bowen's disease) is found on the penis, it is called erythroplasia of Queyrat<ref>http://www.emedicine.com/derm/TOPIC144.HTM</ref>.  This type of cancer respond very well to an experimental agent called Aldara.
====Prostate====
When associated with the prostate, squamous cell carcinoma is very aggressive in nature. It is difficult to detect as there is no increase in [[prostate specific antigen]] levels seen; meaning that the cancer is often diagnosed at an advanced stage.
<div align="left">
<gallery heights="175" widths="175">
Image:Squamous cell carcinoma of prostate.jpg|Prostate: Squamous cell carcinoma
Image:Squamous cell carcinoma of prostate 2.jpg|Prostate: Squamous cell carcinoma
</gallery>
</div>
====Lung====
When associated with the lung, it often causes ectopic production of [[parathyroid hormone-related protein]] (PTHrP), resulting in [[hypercalcemia]].
<div align="left">
<gallery heights="175" widths="175">
Image:Oral cancer (1) squamous cell carcinoma histopathology.jpg|[[Biopsy]] of a highly differentiated squamous cell carcinoma of the mouth. [[H&E stain|Haematoxylin & eosin stain]].
Image:Ca bronchus.jpg|Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus
</gallery>
</div>
====Vagina and cervix====
Vaginal squamous cell carcinoma spreads slowly and usually stays near the vagina, but may spread to the lungs and liver. This is the most common type of [[vaginal cancer]].


=== Cervix: Squamous cell carcinoma===
=== Cervix: Squamous cell carcinoma===

Revision as of 20:04, 16 June 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2], Raviteja Guddeti, M.B.B.S. [3]

Overview

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Cervix: Squamous cell carcinoma

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Future and Investigational treatment strategies

In 2007, Australian biopharmaceutical company Clinuvel Pharmaceuticals Limited began clinical trials with a melanocyte-stimulating hormone called melanotan (known by the International Nonproprietary Name afamelanotide, formerly CUV1647)[1] to provide photoprotection for organ transplant patients against squamous cell carcinoma of the skin and actinic keratosis.[2][3]

Cetuximab a monoclonal antibody that targets the epidermal growth factor receptor (EGFR), has antitumor activity in patients with advanced squamous cell carcinoma of the skin, as initially suggested by case reports.

References

  1. ↑ "World Health Organisation assigns CUV1647 generic name" (PDF). Clinuvel. 2008. Retrieved 2008-06-17.
  2. ↑ Clinuvel » Investors » FAQs
  3. ↑ PharmaAsia - Clinuvel’s Drug Begins Global Phase II Skin Cancer Trials

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