Krüppel-like factor gene transcriptions: Difference between revisions

Associate Editor(s)-in-Chief: Henry A. Hoff

"Krüppel-like factor 1 (KLF1/EKLF) is a transcription factor that globally activates genes involved in erythroid cell development. [...] KLF1 belongs to the KLF family of transcription factors that binds the G-rich strand of so-called CACCC-box motifs located in regulatory regions of numerous erythroid genes."^[1]

Human genes

The following human genes encode Kruppel-like factors: KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17.

Interactions

Consensus sequences

"Using the in vitro CASTing method, we identified a new set of sequences bound by [congenital dyserythropoietic anemia] CDA-KLF1, and based on them we defined the consensus binding site as 5′-NGG-GG(T/G)-(T/G)(T/G)(T/G)-3′. It differs from the consensus binding sites for [wild-type] WT-KLF1, 5′-NGG-G(C/T)G-(T/G)GG-3′, and for [neonatal anemia] Nan-KLF1, 5′-NGG-G(C/A)N-(T/G)GG-3′, as well."^[1]

An apparent consensus is GGG(A/C/G/T)(A/C/G/T)(G/T)(G/T)(G/T).

Samplings

Copying an apparent consensus sequence for the KLF of GGGTCGTG and putting it in "⌘F" finds six located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.

For the Basic programs testing consensus sequence GGGTCGTG (starting with SuccessablesKrup.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:

negative strand, negative direction, looking for AAAAAAAA, 0.
negative strand, positive direction, looking for AAAAAAAA, 0.
positive strand, negative direction, looking for AAAAAAAA, 0.
positive strand, positive direction, looking for AAAAAAAA, 0.
complement, negative strand, negative direction, looking for TTTTTTTT, 0.
complement, negative strand, positive direction, looking for TTTTTTTT, 0.
complement, positive strand, negative direction, looking for TTTTTTTT, 0.
complement, positive strand, positive direction, looking for TTTTTTTT, 0.
inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
inverse negative strand, negative direction, looking for AAAAAAAA, 0.
inverse negative strand, positive direction, looking for AAAAAAAA, 0.
inverse positive strand, negative direction, looking for AAAAAAAA, 0.
inverse positive strand, positive direction, looking for AAAAAAAA, 0.

Krup UTR gene transcriptions

Krup core promoters

Krup proximal promoters

References

↑ ^1.0 ^1.1 Klaudia Kulczynska, James J. Bieker, Miroslawa Siatecka (12 February 2020). "A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity". Molecular and Cellular Biology. 40 (5): e00444–19. doi:10.1128/MCB.00444-19. PMID 31818881. |access-date= requires |url= (help)

External links

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@@ Line 31: / Line 31: @@
 Copying an apparent consensus sequence for the KLF of GGGTCGTG and putting it in "⌘F" finds six located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.
+For the Basic programs testing consensus sequence GGGTCGTG (starting with SuccessablesKrup.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
+# negative strand, negative direction, looking for AAAAAAAA, 0.
+# negative strand, positive direction, looking for AAAAAAAA, 0.
+# positive strand, negative direction, looking for AAAAAAAA, 0.
+# positive strand, positive direction, looking for AAAAAAAA, 0.
+# complement, negative strand, negative direction, looking for TTTTTTTT, 0.
+# complement, negative strand, positive direction, looking for TTTTTTTT, 0.
+# complement, positive strand, negative direction, looking for TTTTTTTT, 0.
+# complement, positive strand, positive direction, looking for TTTTTTTT, 0.
+# inverse complement, negative strand, negative direction, looking for TTTTTTTT, 0.
+# inverse complement, negative strand, positive direction, looking for TTTTTTTT, 0.
+# inverse complement, positive strand, negative direction, looking for TTTTTTTT, 0.
+# inverse complement, positive strand, positive direction, looking for TTTTTTTT, 0.
+# inverse negative strand, negative direction, looking for AAAAAAAA, 0.
+# inverse negative strand, positive direction, looking for AAAAAAAA, 0.
+# inverse positive strand, negative direction, looking for AAAAAAAA, 0.
+# inverse positive strand, positive direction, looking for AAAAAAAA, 0.
+===Krup UTR gene transcriptions===
+{{main|UTR gene transcriptions}}
+===Krup core promoters===
+{{main|Core promoter gene transcriptions}}
+===Krup proximal promoters===
+{{main|Proximal promoter gene transcriptions}}
 ==See also==