p27 (gene)

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Overview

p27 is a human gene on chromosome 6 and belongs to the cip/kip family. It encodes a cell cycle inhibitor protein that binds to cyclin D and CDK4 and causes arrest in G1 phase. p27 is activated by Transforming Growth Factor β (TGF β). A mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation.