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COVID-19 Microchapters



Frequently Asked Outpatient Questions

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Differentiating COVID-19 from other Diseases

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Diagnostic Study of Choice

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Case #1

COVID-19 MRI On the Web

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D. Sabawoon Mirwais, M.B.B.S, M.D.[2] Syed Hassan A. Kazmi BSc, MD [3] Aisha Adigun, B.Sc., M.D.[4]


MRI may be helpful in the diagnosis of COVID-19 complications. Findings on cardiac MRI suggestive of COVID-19 include myocardial edema, scarring, fibrosis, impaired RV function, impaired LV function (reduced ejection fraction), biventricular hypokinesis, late gadolinium enhancement, increased wall thickness, pericardial effusion. Findings on an lung MRI suggestive of pulmonary complications associated with COVID-19 include cloudy sky sign, parenchyma compaction, consolidation, pleural effusion, lung infiltrations with peripheral preference. Findings on an Brain MRI suggestive of neurologic complications associated with COVID-19 include signal abnormalities located in the medial temporal lobe, non-confluent multifocal white matter hyperintense lesions on FLAIR and diffusion sequences, extensive and isolated white matter micro-hemorrhages, intra-cerebral hemorrhagic lesions. Findings on an spine MRI suggestive of neurologic complications associated with COVID-19 include widespread elongated signal changes throughout the gray matter of spinal cord ( Acute transverse myelitis), caudal nerve roots enhanced (Guillain-Barre syndrome).







  1. Han, Yuchi; Chen, Tiffany; Bryant, Jennifer; Bucciarelli-Ducci, Chiara; Dyke, Christopher; Elliott, Michael D.; Ferrari, Victor A.; Friedrich, Matthias G.; Lawton, Chris; Manning, Warren J.; Ordovas, Karen; Plein, Sven; Powell, Andrew J.; Raman, Subha V.; Carr, James (2020). "Society for Cardiovascular Magnetic Resonance (SCMR) guidance for the practice of cardiovascular magnetic resonance during the COVID-19 pandemic". Journal of Cardiovascular Magnetic Resonance. 22 (1). doi:10.1186/s12968-020-00628-w. ISSN 1532-429X.
  2. Puntmann VO, Carerj ML, Wieters I, et al. Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. Published online July 27, 2020. doi:10.1001/jamacardio.2020.3557
  3. Inciardi, Riccardo M.; Lupi, Laura; Zaccone, Gregorio; Italia, Leonardo; Raffo, Michela; Tomasoni, Daniela; Cani, Dario S.; Cerini, Manuel; Farina, Davide; Gavazzi, Emanuele; Maroldi, Roberto; Adamo, Marianna; Ammirati, Enrico; Sinagra, Gianfranco; Lombardi, Carlo M.; Metra, Marco (2020). "Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)". JAMA Cardiology. doi:10.1001/jamacardio.2020.1096. ISSN 2380-6583.
  4. Han, Seongwook; Kim, Hyun Ah; Kim, Jin Young; Kim, In-Cheol (2020). "COVID-19-related myocarditis in a 21-year-old female patient". European Heart Journal. 41 (19): 1859–1859. doi:10.1093/eurheartj/ehaa288. ISSN 0195-668X.
  5. Esposito, Antonio; Godino, Cosmo; Basso, Cristina; Cappelletti, Alberto Maria; Tresoldi, Moreno; De Cobelli, Francesco; Vignale, Davide; Villatore, Andrea; Palmisano, Anna; Gramegna, Mario; Peretto, Giovanni; Sala, Simone (2020). "Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection". European Heart Journal. 41 (19): 1861–1862. doi:10.1093/eurheartj/ehaa286. ISSN 0195-668X.
  6. Coyle, Justin; Igbinomwanhia, Efehi; Sanchez-Nadales, Alejandro; Danciu, Sorin; Chu, Chae; Shah, Nishit (2020). "A Recovered Case of COVID-19 Myocarditis and ARDS Treated With Corticosteroids, Tocilizumab, and Experimental AT-001". JACC: Case Reports. doi:10.1016/j.jaccas.2020.04.025. ISSN 2666-0849.
  7. Doyen, Denis; Moceri, Pamela; Ducreux, Dorothée; Dellamonica, Jean (2020). "Myocarditis in a patient with COVID-19: a cause of raised troponin and ECG changes". The Lancet. 395 (10235): 1516. doi:10.1016/S0140-6736(20)30912-0. ISSN 0140-6736.
  8. Luetkens, Julian Alexander; Isaak, Alexander; Zimmer, Sebastian; Nattermann, Jacob; Sprinkart, Alois Martin; Boesecke, Christoph; Rieke, Gereon Jonas; Zachoval, Christian; Heine, Annkristin; Velten, Markus; Duerr, Georg Daniel (2020). "Diffuse Myocardial Inflammation in COVID-19 Associated Myocarditis Detected by Multiparametric Cardiac Magnetic Resonance Imaging". Circulation: Cardiovascular Imaging. 13 (5). doi:10.1161/CIRCIMAGING.120.010897. ISSN 1941-9651.
  9. Inciardi, Riccardo M.; Lupi, Laura; Zaccone, Gregorio; Italia, Leonardo; Raffo, Michela; Tomasoni, Daniela; Cani, Dario S.; Cerini, Manuel; Farina, Davide; Gavazzi, Emanuele; Maroldi, Roberto; Adamo, Marianna; Ammirati, Enrico; Sinagra, Gianfranco; Lombardi, Carlo M.; Metra, Marco (2020). "Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19)". JAMA Cardiology. doi:10.1001/jamacardio.2020.1096. ISSN 2380-6583.
  10. Huang, Lu; Zhao, Peijun; Tang, Dazhong; Zhu, Tong; Han, Rui; Zhan, Chenao; Liu, Weiyong; Zeng, Hesong; Tao, Qian; Xia, Liming (2020). "Cardiac involvement in recovered COVID-19 patients identified by magnetic resonance imaging". JACC: Cardiovascular Imaging. doi:10.1016/j.jcmg.2020.05.004. ISSN 1936-878X.
  11. Vasilev, Yuriy; Sergunova, Kristina; Bazhin, Alexander; Masri, Amir; Vasileva, Yulia; Suleumanov, Elhan; Semenov, Dmitry; Kudryavtsev, Nikita; Panina, Olga; Khoruzhaya, Anna; Znichenko, Victoria; Akhmad, Ekaterina; Petraikin, Alexey; Vladzymyrskyy, Anton; Midaev, Aslanbek; Morozov, Sergey (2020). doi:10.1101/2020.05.13.20088732. Missing or empty |title= (help)
  12. Langenbach, Marcel C.; Hokamp, Nils Grosse; Persigehl, Thorsten; Bratke, Grischa (2020). "MRI appearance of COVID-19 infection". Diagnostic and Interventional Radiology. 26 (4): 377–378. doi:10.5152/dir.2020.20152. ISSN 1305-3612.
  13. Kremer, Stéphane; Lersy, François; de Sèze, Jérome; Ferré, Jean-Christophe; Maamar, Adel; Carsin-Nicol, Béatrice; Collange, Olivier; Bonneville, Fabrice; Adam, Gilles; Martin-Blondel, Guillaume; Rafiq, Marie; Geeraerts, Thomas; Delamarre, Louis; Grand, Sylvie; Krainik, Alexandre; Caillard, Sophie; Marc Constans, Jean; Metanbou, Serge; Heintz, Adrien; Helms, Julie; Schenck, Maleka; Lefèbvre, Nicolas; Boutet, Claire; Fabre, Xavier; Forestier, Géraud; de Beaurepaire, Isaure; Bornet, Grégoire; Lacalm, Audrey; Oesterlé, Hélène; Bolognini, Federico; Messie, Julien; Hmeydia, Ghazi; Benzakoun, Joseph; Oppenheim, Catherine; Bapst, Blanche; Megdiche, Imen; Henri-Feugeas, Marie-Cécile; Khalil, Antoine; Gaudemer, Augustin; Jager, Lavinia; Nesser, Patrick; Talla Mba, Yannick; Hemmert, Céline; Feuerstein, Philippe; Sebag, Nathan; Carré, Sophie; Alleg, Manel; Lecocq, Claire; Schmitt, Emmanuelle; Anxionnat, René; Zhu, François; Comby, Pierre-Olivier; Ricolfi, Frédéric; Thouant, Pierre; Desal, Hubert; Boulouis, Grégoire; Berge, Jérome; Kazémi, Apolline; Pyatigorskaya, Nadya; Lecler, Augustin; Saleme, Suzana; Edjlali-Goujon, Myriam; Kerleroux, Basile; Zorn, Pierre-Emmanuel; Mathieu, Muriel; Baloglu, Seyyid; Ardellier, François-Daniel; Willaume, Thibault; Brisset, Jean Christophe; Boulay, Clotilde; Mutschler, Véronique; Hansmann, Yves; Mertes, Paul-Michel; Schneider, Francis; Fafi-Kremer, Samira; Ohana, Mickael; Meziani, Ferhat; David, Jean-Stéphane; Meyer, Nicolas; Anheim, Mathieu; Cotton, Pr François (2020). "Brain MRI Findings in Severe COVID-19: A Retrospective Observational Study". Radiology: 202222. doi:10.1148/radiol.2020202222. ISSN 0033-8419.
  14. "A Case Report of Acute Transverse Myelitis Following Novel Coronavirus Infection".
  15. Toscano, Gianpaolo; Palmerini, Francesco; Ravaglia, Sabrina; Ruiz, Luigi; Invernizzi, Paolo; Cuzzoni, M. Giovanna; Franciotta, Diego; Baldanti, Fausto; Daturi, Rossana; Postorino, Paolo; Cavallini, Anna; Micieli, Giuseppe (2020). "Guillain–Barré Syndrome Associated with SARS-CoV-2". New England Journal of Medicine. 382 (26): 2574–2576. doi:10.1056/NEJMc2009191. ISSN 0028-4793.