Template:Amino acid metabolism enzymes: Difference between revisions

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{{Navbox
{{Navbox
| name = Amino acid metabolism enzymes
| name = Amino acid metabolism enzymes
| title = [[Amino acid]] [[Amino acid synthesis|metabolism]] enzymes ([[Essential amino acid|essential]] in CAPS)
| title = [[Metabolism]]: [[Protein metabolism]], [[Amino acid synthesis|synthesis]] and catabolism [[enzyme]]s
| style =  
| state = {{{state|}}}
| titlestyle = background:#e7dcc3
| listclass = hlist
| groupstyle = background-color: AntiqueWhite


| above= ''[[Essential amino acid]]s are in Capitals''


| group1 = [[Ketogenic amino acid|K]]
| group1 = [[Ketogenic amino acid|K]]→[[acetyl-CoA]]
| list1 = {{Navbox subgroup
| list1 = {{Navbox|child
  | groupstyle = background-color: AntiqueWhite


  | group1 = [[lysine|LYSINE]]→[[acetyl-CoA]]
  | group1 = [[lysine|LYSINE]]→
  | list1 = [[Saccharopine dehydrogenase]] - [[Glutaryl-CoA dehydrogenase]]
  | list1 =
* [[Saccharopine dehydrogenase]]
* [[Glutaryl-CoA dehydrogenase]]


  | group2 = [[leucine|LEUCINE]]→[[acetyl-CoA]]
  | group2 = [[leucine|LEUCINE]]→
  |  list2 = [[Branched-chain alpha-keto acid dehydrogenase complex]] - [[Isovaleryl coenzyme A dehydrogenase]] - [[Methylcrotonyl-CoA carboxylase]]  
  | list2 =
* [[3-Hydroxybutyryl-CoA dehydrogenase]]
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[Enoyl-CoA hydratase]]
* [[3-hydroxy-3-methylglutaryl-CoA lyase|HMG-CoA lyase]]
* [[HMG-CoA reductase]]
* [[Isovaleryl coenzyme A dehydrogenase]]
* [[α-ketoisocaproate dioxygenase|α-Ketoisocaproate dioxygenase]]
* [[Leucine 2,3-aminomutase]]
* [[Methylcrotonyl-CoA carboxylase]]
* [[Methylglutaconyl-CoA hydratase]]
(See [[Template:Leucine metabolism in humans]] – this diagram does not include the pathway for β-leucine synthesis via leucine 2,3-aminomutase)


  | group3 = [[tryptophan|TRYPTOPHAN]]→[[acetyl-CoA]]
  | group3 = [[tryptophan|TRYPTOPHAN]]→
  |  list3 = [[Kynureninase]]
  | list3 =
* [[Indoleamine 2,3-dioxygenase]]/[[Tryptophan 2,3-dioxygenase]]
* [[Arylformamidase]]
* [[Kynureninase]]
* [[3-hydroxyanthranilate oxidase]]
* [[Aminocarboxymuconate-semialdehyde decarboxylase]]
* [[Aminomuconate-semialdehyde dehydrogenase]]


  | group4 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→[[acetoacetate]]
  | group4 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
  | list4 = (see below)
  | list4 =
* (see below)


}}
}}


| group2 = [[Glucogenic amino acid|G]]
| group2 = [[Glucogenic amino acid|G]]
| list2 = {{Navbox subgroup
| list2 = {{Navbox|child
  | groupstyle = background-color: AntiqueWhite


  | group1 = [[glycine]]→[[serine]]→[[pyruvate]]→TCA
  | group1 = G→[[pyruvate]]<br />→[[citrate]]
  | list1 = [[Serine hydroxymethyltransferase]] - [[Serine dehydratase]]
  | list1 = {{Navbox|child


  | group2 = [[alanine]]→[[pyruvate]]→TCA
    | group1 = [[glycine]]→[[serine]]→
  | list2 = [[Alanine transaminase]]
    | list1 =
* [[Serine hydroxymethyltransferase]]
* [[Serine dehydratase]]


  | group3 = [[cysteine]]→[[pyruvate]]→TCA
* [[glycine]]→[[creatine]]: [[Guanidinoacetate N-methyltransferase]]
  |  list3 = [[D-cysteine desulfhydrase]]
* [[Creatine kinase]]


  | group4 = [[threonine]]→[[pyruvate]]→TCA
    | group2 = [[alanine]]→
  | list4 = [[L-threonine dehydrogenase]]
    | list2 =
* [[Alanine transaminase]]


  | group5 = [[histidine|HISTIDINE]]→[[glutamate]]
    | group3 = [[cysteine]]→
  | list5 = [[Histidine ammonia-lyase]] - [[Urocanate hydratase]] - [[Formiminotransferase cyclodeaminase]]
    | list3 =
* [[D-cysteine desulfhydrase]]


  | group6 = [[proline]]→[[glutamate]]
    | group4 = [[threonine]]→
  | list6 = [[Proline oxidase]] - [[Pyrroline-5-carboxylate reductase]] - [[1-Pyrroline-5-carboxylate dehydrogenase]]/[[ALDH4A1]] - [[PYCR1]]
    | list4 =
* [[L-threonine dehydrogenase]]


  | group7 = [[arginine]]→[[glutamate]]
  }}
  |  list7 = [[Ornithine aminotransferase]] - [[Ornithine decarboxylase]] - [[Agmatinase]]


  | group8 = [[glutamate]]→[[alpha-ketoglutarate]]→TCA
  | group3 = G→[[glutamate]]→<br />[[alpha-Ketoglutaric acid|α-ketoglutarate]]
  | list8 = [[Glutamate dehydrogenase]]
  | list3 = {{Navbox|child


  | group9 = [[methionine|METHIONINE]]→[[propionyl-CoA]]
    | group5 = [[histidine|HISTIDINE]]→
  | list9 = [[Methionine adenosyltransferase]] - [[Adenosylhomocysteinase]] - (or [[5-Methyltetrahydrofolate-homocysteine methyltransferase|MTR]]/[[Homocysteine methyltransferase]]) - [[Cystathionine beta synthase]] - [[Cystathionine gamma-lyase]]
    | list5 =
* [[Histidine ammonia-lyase]]
* [[Urocanase|Urocanate hydratase]]
* [[Formiminotransferase cyclodeaminase]]


  | group10 = [[isoleucine|ISOLEUCINE]]/[[valine]]→[[propionyl-CoA]]
    | group6 = [[proline]]→
  |  list10 = [[Branched-chain alpha-keto acid dehydrogenase complex]]
    | list6 =
* [[Proline oxidase]]
* [[Pyrroline-5-carboxylate reductase]]
* [[1-Pyrroline-5-carboxylate dehydrogenase]]/[[Aldehyde dehydrogenase 4 family, member A1|ALDH4A1]]
* [[PYCR1]]


  | group11 = [[threonine|THREONINE]]→[[propionyl-CoA]]
    | group7 = [[arginine]]→
  |  list11 = [[Threonine aldolase]]
    | list7 =
* [[Ornithine aminotransferase]]
* [[Ornithine decarboxylase]]
* [[Agmatinase]]


  | group12 = [[propionyl-CoA]]→[[succinyl-CoA]]→TCA
    | group8 = →[[alpha-ketoglutarate]]→TCA
  | list12 = [[Propionyl-CoA carboxylase]] - [[Methylmalonyl-CoA mutase]]
    | list8 =
* [[Glutamate dehydrogenase]]


  | group13 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→[[fumarate]]→TCA
    | group9 = Other
  |  list13 = [[Phenylalanine hydroxylase]] - [[Tyrosine aminotransferase]] - [[4-Hydroxyphenylpyruvate dioxygenase]] - [[Homogentisate 1,2-dioxygenase]] - [[Fumarylacetoacetate hydrolase]]
    | list9 =
* [[cysteine]]+[[glutamate]]→[[glutathione]]: [[Gamma-glutamylcysteine synthetase]]
* [[Glutathione synthetase]]
* [[Gamma-glutamyl transpeptidase]]


  | group14 = [[asparagine]]→[[aspartate]]→[[oxaloacetate]]→TCA
* [[glutamate]]→[[glutamine]]: [[Glutamine synthetase]]
  |  list14 = [[Asparaginase]]/[[Asparagine synthetase]] - [[Aspartate transaminase]]
* [[Glutaminase]]


}}
  }}


| group3 = [[Neurotransmitter|NT]]
  | group4 = G→[[propionyl-CoA]]→<br />[[succinyl-CoA]]
| list3 = {{Navbox subgroup
  | list4 = {{Navbox|child
  | groupstyle = background-color: AntiqueWhite


  | group1 = [[histidine|HISTIDINE]]→[[histamine]]
    | group1 = [[valine|VALINE]]→
  |  list1 = [[Histidine decarboxylase]]
    | list1 =
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[Enoyl-CoA hydratase]]
* [[3-hydroxyisobutyryl-CoA hydrolase]]
* [[3-hydroxyisobutyrate dehydrogenase]]
* [[Methylmalonate-semialdehyde dehydrogenase (acylating)|Methylmalonate semialdehyde dehydrogenase]]


  | group2 = [[tyrosine]]→[[dopamine]]→[[epinephrine]]
    | group2 = [[isoleucine|ISOLEUCINE]]→
  | list2 = [[Tyrosine hydroxylase]] - [[Aromatic L-amino acid decarboxylase]] - [[Dopamine beta hydroxylase]] - [[Phenylethanolamine N-methyltransferase]] - [[Catechol-O-methyl transferase]]
    | list2 =
* [[Branched-chain amino acid aminotransferase]]
* [[Branched-chain alpha-keto acid dehydrogenase complex]]
* [[3-hydroxy-2-methylbutyryl-CoA dehydrogenase]]


  | group3 = [[glutamate]]→[[Gamma-aminobutyric acid|GABA]]
    | group3 = [[methionine|METHIONINE]]→
  |  list3 = [[Glutamate decarboxylase]]
    | list3 =
* ''[[Methionine#Generation of homocysteine|generation of homocysteine]]:'' [[Methionine adenosyltransferase]]
* [[Adenosylhomocysteinase]]


  | group4 = [[arginine]]→[[Nitric oxide|NO]]
* ''[[Methionine#Regeneration of methionine|regeneration of methionine]]:'' [[Methionine synthase]]/[[methionine synthase|Homocysteine methyltransferase]]
  |  list4 = [[Nitric oxide synthase]]
* [[Betaine-homocysteine S-methyltransferase|Betaine-homocysteine methyltransferase]]


}}
* ''[[Methionine#Conversion to cysteine|conversion to cysteine]]:'' [[Cystathionine beta synthase]]
* [[Cystathionine gamma-lyase]]


| group4 = Other
    | group4 = [[threonine|THREONINE]]→
| list4 = {{Navbox subgroup
    | list4 =
  | groupstyle = background-color: AntiqueWhite
* [[Threonine aldolase]]


  | group1 = [[tyrosine]]→[[melanin]]
    | group5 = →[[succinyl-CoA]]→TCA
  |  list1 = [[Tyrosinase]]
    | list5 =
* [[Propionyl-CoA carboxylase]]
* [[Methylmalonyl CoA epimerase]]
* [[Methylmalonyl-CoA mutase]]


  | group2 = [[tryptophan|TRYPTOPHAN]]→[[serotonin]]→[[melatonin]]
  }}
  |  list2 = [[Tryptophan hydroxylase]] - [[Aromatic L-amino acid decarboxylase]] - [[Acetylserotonin O-methyltransferase]]


  | group3 = [[cysteine]]+[[glutamate]]→[[glutathione]]
  | group5 = G→[[fumarate]]
  | list3 = [[Gamma-glutamylcysteine synthetase]] - [[Glutathione synthetase]]
  | list5 = {{Navbox|child


  | group4 = [[glycine]]→[[creatine]]
    | group13 = [[phenylalanine|PHENYLALANINE]]→[[tyrosine]]→
  | list4 = [[Guanidinoacetate N-methyltransferase]] - [[Creatine kinase]]
    | list13 =
* [[Phenylalanine hydroxylase]]
* [[Tyrosine aminotransferase]]
* [[4-Hydroxyphenylpyruvate dioxygenase]]
* [[Homogentisate 1,2-dioxygenase]]
* [[Fumarylacetoacetate hydrolase]]


  | group5 = [[glutamate]]→[[glutamine]]
* [[tyrosine]]→[[melanin]]: [[Tyrosinase]]
  |  list5 = [[Glutamine synthetase]] - [[Glutaminase]]


  | group6 = [[collagen]]
  }}
  |  list6 = [[Prolyl hydroxylase]] - [[Lysyl hydroxylase]]


}}
  | group6 = G→[[Oxaloacetic acid|oxaloacetate]]
  | list6 = {{Navbox|child


| group5 =  
    | group14 = [[asparagine]]→[[aspartate]]→
| list5 = ''see also [[Template:Amino acid metabolic pathology|disorders]], [[Template:Amino acid metabolism intermediates|intermediates]]''
    | list14 =
* [[Asparaginase]]/[[Asparagine synthetase]]
* [[Aspartate transaminase]]
 
  }}
}}


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[[Category:Amino acid metabolic pathway templates]]
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Revision as of 23:58, 14 June 2018

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