Aminomuconate-semialdehyde dehydrogenase

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In enzymology, an aminomuconate-semialdehyde dehydrogenase (EC 1.2.1.32) is an enzyme that catalyzes the chemical reaction

2-aminomuconate 6-semialdehyde + NAD+ + H2O 2-aminomuconate + NADH + 2 H+

The 3 substrates of this enzyme are 2-aminomuconate 6-semialdehyde, NAD+, and H2O, whereas its 3 products are 2-aminomuconate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-aminomuconate-6-semialdehyde:NAD+ 6-oxidoreductase. Other names in common use include 2-aminomuconate semialdehyde dehydrogenase, 2-hydroxymuconic acid semialdehyde dehydrogenase, 2-hydroxymuconate semialdehyde dehydrogenase, alpha-aminomuconic epsilon-semialdehyde dehydrogenase, alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase, and 2-hydroxymuconic semialdehyde dehydrogenase. This enzyme participates in 3 metabolic pathways: benzoic acid degradation via hydroxylation, tryptophan metabolism, and the degradation pathway for toluene and xylene.

References

  • IUBMB entry for 1.2.1.32
  • BRENDA references for 1.2.1.32 (Recommended.)
  • PubMed references for 1.2.1.32
  • PubMed Central references for 1.2.1.32
  • Google Scholar references for 1.2.1.32
  • SENOH S (1965). "STUDIES ON THE METABOLISM OF THE BENZENE RING OF TRYPTOPHAN IN MAMMALIAN TISSUES. II. ENZYMIC FORMATION OF ALPHA-AMINOMUCONIC ACID FROM 3-HYDROXYANTHRANILIC ACID". J. Biol. Chem. 240: 740&ndash, 9. PMID 14275130.

External links

The CAS registry number for this enzyme class is 37250-95-6.

Gene Ontology (GO) codes

Template:1.2-enzyme-stub


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