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In enzymology, an arylformamidase (EC is an enzyme that catalyzes the chemical reaction

N-formyl-L-kynurenine + H2O formate + L-kynurenine

Thus, the two substrates of this enzyme are N-formyl-L-kynurenine and H2O, whereas its two products are formate and L-kynurenine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is aryl-formylamine amidohydrolase. Other names in common use include kynurenine formamidase, formylase, formylkynureninase, formylkynurenine formamidase, formamidase I, and formamidase II. This enzyme participates in tryptophan metabolism and glyoxylate and dicarboxylate metabolism.


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  • HAYAISHI O, STANIER RY (1951). "The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway". J. Bacteriol. 62: 691&ndash, 709. PMID 14907621.
  • JAKOBY WB (1954). "Kynurenine formamidase from Neurospora". J. Biol. Chem. 207: 657&ndash, 63. PMID 13163050.
  • MEHLER AH, KNOX WE (1950). "The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine". J. Biol. Chem. 187: 431&ndash, 8. PMID 14794728.

External links

The CAS registry number for this enzyme class is 156229-75-3.

Gene Ontology (GO) codes