Profenamine: Difference between revisions

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{{drugbox
 
|IUPAC_name=''N'',''N''-diethyl-1-(10''H''-phenothiazin-10-yl)propan-2-amine
{{Drugbox
|image=Profenamine.svg
| verifiedrevid = 464215203
|CAS_number=1094-08-2
| IUPAC_name = ''N'',''N''-diethyl-1-(10''H''-phenothiazin-10-yl)propan-2-amine
|ATC_prefix=N04
| image = Profenamine.svg
|ATC_suffix=AA05
 
|ATC_supplemental=
<!--Clinical data-->
|PubChem=3290
| tradename =
|DrugBank=APRD00729
| Drugs.com = {{drugs.com|international|profenamine}}
|C=19|H=24|N=2|S=1
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
|molecular_weight=312.473 g/mol
| pregnancy_US = <!-- A / B / C / D / X -->
|bioavailability=
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
|protein_bound=93%
| legal_UK = <!-- GSL / P / POM / CD -->
|metabolism=
| legal_US = <!-- OTC / Rx-only -->
|elimination_half-life=1 to 2 hours
 
|excretion=
<!--Pharmacokinetic data-->
|pregnancy_AU=<!-- A / B1 / B2 / B3 / C / D / X -->
| protein_bound = 93%
|pregnancy_US=<!-- A / B / C / D / X -->
| elimination_half-life = 1 to 2 hours
|pregnancy_category=
 
|legal_AU=<!-- Unscheduled / S2 / S4 / S8 -->
<!--Identifiers-->
|legal_UK=<!-- GSL / P / POM / CD -->
| CASNo_Ref = {{cascite|correct|CAS}}
|legal_US=<!-- OTC / Rx-only -->
| CAS_number_Ref = {{cascite|correct|??}}
|legal_status=
| CAS_number = 1094-08-2
|routes_of_administration=
| ATC_prefix = N04
| ATC_suffix = AA05
| PubChem = 3290
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00392
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 3174
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = O00T1I1VRN
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 313639
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 1206
 
<!--Chemical data-->
| C=19 | H=24 | N=2 | S=1
| molecular_weight = 312.473 g/mol
| smiles = S2c1ccccc1N(c3c2cccc3)CC(N(CC)CC)C
| InChI = 1/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
| InChIKey = CDOZDBSBBXSXLB-UHFFFAOYAV
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = CDOZDBSBBXSXLB-UHFFFAOYSA-N
}}
}}
'''Profenamine hydrochloride''' ([[International Nonproprietary Name|INN]], also known as '''ethopropazine''') is a [[medication]] derived from [[phenothiazine]]. It is primarily used as an [[antidyskinetic]] to treat [[parkinsonism]].
It is sold under the trade names '''Parsidol''' in the [[United States]] and '''Parsidan''' in [[Canada]].


{{pharma-stub}}
'''Profenamine''' ([[International Nonproprietary Name|INN]], trade names '''Parsidol''', '''Parsidan''', '''Parkin'''), also known as '''ethopropazine''' ([[British Approved Name|BAN]]), is a [[phenothiazine]] [[chemical derivative|derivative]] used as an [[antiparkinsonian]] agent that has [[anticholinergic]], [[antihistamine]], and [[antiadrenergic]] actions. It is also used in the alleviation of the [[extrapyramidal syndrome]] induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against [[tardive dyskinesia]].
{{Anti-parkinson anticholinergic agents}}
== References ==
{{Reflist}}
 
 
{{Antiparkinson}}
{{Adrenergics}}
{{Cholinergics}}
{{Histaminergics}}
{{Tricyclics}}
 
[[Category:Phenothiazines]]
[[Category:Phenothiazines]]
{{nervous-system-drug-stub}}

Revision as of 20:26, 12 April 2015

Profenamine
File:Profenamine.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Pharmacokinetic data
Protein binding93%
Elimination half-life1 to 2 hours
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H24N2S
Molar mass312.473 g/mol
3D model (JSmol)
  (verify)

Profenamine (INN, trade names Parsidol, Parsidan, Parkin), also known as ethopropazine (BAN), is a phenothiazine derivative used as an antiparkinsonian agent that has anticholinergic, antihistamine, and antiadrenergic actions. It is also used in the alleviation of the extrapyramidal syndrome induced by drugs such as other phenothiazine compounds, but, like other compounds with antimuscarinic properties, is of no value against tardive dyskinesia.

References


Template:Antiparkinson

Template:Tricyclics


Template:Nervous-system-drug-stub

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