Celiprolol

Celiprolol

Clinical data
ATC code	C07AB08 (WHO)
Identifiers
IUPAC name N'-(3-Acetyl-4-(3-((1,1-dimethylethyl)amino) - 2-hydroxypropoxy)phenyl)-N,N-diethylurea
CAS Number	56980-93-9
PubChem CID	2663
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C20H33N3O4
Molar mass	379.49 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alonso Alvarado, M.D. [2]

Overview

Celiprolol (brand names Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.

A recent clinical trial has suggested a use for this medication in the prevention of vascular complications of a rare inherited disease called vascular Ehlers-Danlos syndrome. This study demonstrated decreased incidence of arterial rupture or dissection (a specific type of arterial rupture in which the layers of the vessel separate prior to complete failure of the artery wall).

External Links

• Selectol Summary of Product Characteristics (from the IPHA Medicines Compendium)
• Celiprolol data sheet for New Zealand