P2RX5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''P2X purinoceptor 5''' is a [[protein]] that in humans is encoded by the ''P2RX5'' [[gene]].<ref name="pmid9414125">{{cite journal | vauthors = Le KT, Paquet M, Nouel D, Babinski K, Seguela P | title = Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system | journal = FEBS Lett | volume = 418 | issue = 1–2 | pages = 195–9 |date=Jan 1998 | pmid = 9414125 | pmc =  | doi =10.1016/S0014-5793(97)01380-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Purinergic receptor P2X, ligand-gated ion channel, 5
| HGNCid = 8536
| Symbol = P2RX5
| AltSymbols =; MGC47755; P2X5; P2X5R
| OMIM = 602836
| ECnumber = 
| Homologene = 1924
| MGIid = 2137026
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5026
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002552
    | Hs_RefseqmRNA = NM_002561
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 94045
    | Mm_Ensembl = ENSMUSG00000005950
    | Mm_RefseqmRNA = NM_033321
    | Mm_RefseqProtein = NP_201578
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 72976720
    | Mm_GenLoc_end = 72988880
    | Mm_Uniprot = 
  }}
}}
'''Purinergic receptor P2X, ligand-gated ion channel, 5''', also known as '''P2RX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5026| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez" />
}}
}}


Line 57: Line 12:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 63: Line 18:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013-67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal   |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal   |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146 }}
*{{cite journal  | author=Lê KT, Paquet M, Nouel D, ''et al.'' |title=Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system. |journal=FEBS Lett. |volume=418 |issue= 1-2 |pages= 195-9 |year= 1998 |pmid= 9414125 |doi=  }}
*{{cite journal   |vauthors=Touchman JW, Anikster Y, Dietrich NL, etal |title=The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion |journal=Genome Res. |volume=10 |issue= 2 |pages= 165–73 |year= 2000 |pmid= 10673275 |doi=10.1101/gr.10.2.165  | pmc=310836 }}
*{{cite journal | author=Touchman JW, Anikster Y, Dietrich NL, ''et al.'' |title=The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. |journal=Genome Res. |volume=10 |issue= 2 |pages= 165-73 |year= 2000 |pmid= 10673275 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Greig AV, Linge C, Terenghi G, etal |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007–15 |year= 2003 |pmid= 12787128 |doi=10.1046/j.1523-1747.2003.12261.x }}
*{{cite journal | author=Greig AV, Linge C, Terenghi G, ''et al.'' |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007-15 |year= 2003 |pmid= 12787128 |doi=  }}
*{{cite journal   |vauthors=Greig AV, Linge C, Healy V, etal |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315–27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
*{{cite journal | author=Greig AV, Linge C, Healy V, ''et al.'' |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315-27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=de Rijke B, van Horssen-Zoetbrood A, Beekman JM, etal |title=A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3506–16 |year= 2006 |pmid= 16322791 |doi= 10.1172/JCI24832 | pmc=1297240 }}
*{{cite journal | author=de Rijke B, van Horssen-Zoetbrood A, Beekman JM, ''et al.'' |title=A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia. |journal=J. Clin. Invest. |volume=115 |issue= 12 |pages= 3506-16 |year= 2006 |pmid= 16322791 |doi= 10.1172/JCI24832 }}
*{{cite journal  | vauthors=Metcalfe MJ, Baker DM, Burnstock G |title=Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency |journal=Arch. Dermatol. Res. |volume=298 |issue= 6 |pages= 301–7 |year= 2007 |pmid= 16967306 |doi= 10.1007/s00403-006-0693-x }}
*{{cite journal  | author=Metcalfe MJ, Baker DM, Burnstock G |title=Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency. |journal=Arch. Dermatol. Res. |volume=298 |issue= 6 |pages= 301-7 |year= 2007 |pmid= 16967306 |doi= 10.1007/s00403-006-0693-x }}
*{{cite journal  | vauthors=Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G |title=P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39561–72 |year= 2007 |pmid= 17001079 |doi= 10.1074/jbc.M606113200 }}
*{{cite journal  | author=Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G |title=P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39561-72 |year= 2007 |pmid= 17001079 |doi= 10.1074/jbc.M606113200 }}
}}
}}
{{refend}}
{{refend}}
Line 82: Line 36:
* {{MeshName|P2RX5+protein,+human}}
* {{MeshName|P2RX5+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
{{Purinergics}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 17:25, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene.[1][2]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]

See also

References

  1. ↑ Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125.
  2. ↑ 2.0 2.1 "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=P2RX5&oldid=1418027"