CHRNA2
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| Cholinergic receptor, nicotinic, alpha 2 (neuronal)
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| Identifiers | ||||||||||||||
| Symbol(s) | CHRNA2; | |||||||||||||
| External IDs | OMIM: 118502 MGI: 87886 Homologene: 20193 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 1135 | 110902 | ||||||||||||
| Ensembl | ENSG00000120903 | ENSMUSG00000022041 | ||||||||||||
| Uniprot | Q15822 | Q8VI12 | ||||||||||||
| Refseq | NM_000742 (mRNA) NP_000733 (protein) | NM_144803 (mRNA) NP_659052 (protein) | ||||||||||||
| Location | Chr 8: 27.37 - 27.39 Mb | Chr 14: 65.1 - 65.11 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Cholinergic receptor, nicotinic, alpha 2 (neuronal), also known as CHRNA2, is a human gene.[1]
See also
References
Further reading
- Hogg RC, Raggenbass M, Bertrand D (2003). "Nicotinic acetylcholine receptors: from structure to brain function.". Rev. Physiol. Biochem. Pharmacol. 147: 1-46. doi:10.1007/s10254-003-0005-1. PMID 12783266.
- Anand R, Lindstrom J (1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans.". Genomics 13 (4): 962-7. PMID 1505988.
- Wood S, Schertzer M, Yaremko ML (1995). "Identification of the human neuronal nicotinic cholinergic alpha 2 receptor locus, (CHRNA2), within an 8p21 mapped locus, by sequence homology with rat DNA.". Somat. Cell Mol. Genet. 21 (2): 147-50. PMID 7570187.
- García-Colunga J, Miledi R (1995). "Effects of serotonergic agents on neuronal nicotinic acetylcholine receptors.". Proc. Natl. Acad. Sci. U.S.A. 92 (7): 2919-23. PMID 7708749.
- Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.". J. Mol. Neurosci. 7 (3): 217-28. PMID 8906617.
- Chavez-Noriega LE, Crona JH, Washburn MS, et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes.". J. Pharmacol. Exp. Ther. 280 (1): 346-56. PMID 8996215.
- Navaneetham D, Penn A, Howard J, Conti-Fine BM (1997). "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses.". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433-42. PMID 9193799.
- Sato KZ, Fujii T, Watanabe Y, et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.". Neurosci. Lett. 266 (1): 17-20. PMID 10336173.
- Bertrand D, Picard F, Le Hellard S, et al. (2002). "How mutations in the nAChRs can cause ADNFLE epilepsy.". Epilepsia 43 Suppl 5: 112-22. PMID 12121305.
- Jin P, Fu GK, Wilson AD, et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.". Genomics 83 (4): 566-71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
- Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331-5. doi:10.1038/nature04406. PMID 16421571.
- Aridon P, Marini C, Di Resta C, et al. (2006). "Increased sensitivity of the neuronal nicotinic receptor alpha 2 subunit causes familial epilepsy with nocturnal wandering and ictal fear.". Am. J. Hum. Genet. 79 (2): 342-50. doi:10.1086/506459. PMID 16826524.
External links
Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Ion channel, receptor: ligand-gated ion channels | |
|---|---|
| Cys-loop receptors | 5-HT receptor (5-HT3 serotonin receptor (A)) - GABA receptor (GABA A (α1, α2, α3, α5, α6, β1, β2, β3, γ2, ε), GABA C (ρ1)) - Glycine receptor (α1) - Nicotinic acetylcholine receptor (α1, α2, α3, α4, α5, α7, β2, β3, β4, δ, ε, (α4)2(β2)3, (α7)5, Ganglion type, Muscle type) |
| Ionotropic glutamate receptors | AMPA (1, 2, 3, 4) - Kainate (1, 2) - NMDA (1, 2A, 2B, 2C, 2D) |
| ATP-gated channels | Purinergic receptors (P2X (1, 4, 5, 7)) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
