Alpha-7 nicotinic receptor

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File:Icp-lg.jpg
Molecular model of the alpha7 nicotinic receptor.

The alpha-7 nicotinic receptor (α7)5 is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits [1].

It is located in the brain, where activation yields post- and presynaptic excitation[1], mainly by increased Ca2+ permeability.

Agonists

Nicotinic agonists for this receptor include:

Antagonists

  • α-conotoxin ArIB[V11L,V16D][2]

References

  1. 1.0 1.1 Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138.
  2. Whiteaker P, Christensen S, Yoshikami D, Dowell C, Watkins M, Gulyas J, Rivier J, Olivera BM, McIntosh JM. Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist.Biochemistry. 2007 Jun 5;46(22):6628-38. http://pubs.acs.org/cgi-bin/abstract.cgi/bichaw/2007/46/i22/abs/bi7004202.html




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