P2RX1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''P2X purinoceptor 1''' is a [[protein]] that in humans is encoded by the ''P2RX1'' [[gene]].<ref name="pmid8834001">{{cite journal | vauthors = Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN | title = Characterization and chromosomal localization of a human P2X receptor from the urinary bladder | journal = Receptors Channels | volume = 3 | issue = 4 | pages = 283–9 |date=Nov 1996 | pmid = 8834001 | pmc =  | doi =  }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Purinergic receptor P2X, ligand-gated ion channel, 1
| HGNCid = 8533
| Symbol = P2RX1
| AltSymbols =; P2X1
| OMIM = 600845
| ECnumber = 
| Homologene = 1921
| MGIid = 1098235
| GeneAtlas_image1 = PBB_GE_P2RX1_210401_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004931 |text = ATP-gated cation channel activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5023
    | Hs_Ensembl = ENSG00000108405
    | Hs_RefseqProtein = NP_002549
    | Hs_RefseqmRNA = NM_002558
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3746640
    | Hs_GenLoc_end = 3766709
    | Hs_Uniprot = P51575
    | Mm_EntrezGene = 18436
    | Mm_Ensembl = ENSMUSG00000020787
    | Mm_RefseqmRNA = NM_008771
    | Mm_RefseqProtein = NP_032797
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 72815337
    | Mm_GenLoc_end = 72831395
    | Mm_Uniprot = Q91WI3
  }}
}}
 
{{CMG}}
 
 
 
'''Purinergic receptor P2X, ligand-gated ion channel, 1''', also known as '''P2RX1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets.  Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5023| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets.  Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.<ref name="entrez">{{cite web | title = Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5023| accessdate = }}</ref>
}}
}}


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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013-67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal  | author=North RA |title=Molecular physiology of P2X receptors. |journal=Physiol. Rev. |volume=82 |issue= 4 |pages= 1013–67 |year= 2002 |pmid= 12270951 |doi= 10.1152/physrev.00015.2002 }}
*{{cite journal  | author=Longhurst PA, Schwegel T, Folander K, Swanson R |title=The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17. |journal=Biochim. Biophys. Acta |volume=1308 |issue= 3 |pages= 185-8 |year= 1996 |pmid= 8809107 |doi=  }}
*{{cite journal  | vauthors=Longhurst PA, Schwegel T, Folander K, Swanson R |title=The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17. |journal=Biochim. Biophys. Acta |volume=1308 |issue= 3 |pages= 185–8 |year= 1996 |pmid= 8809107 |doi=  10.1016/0167-4781(96)00112-1}}
*{{cite journal  | author=Valera S, Talabot F, Evans RJ, ''et al.'' |title=Characterization and chromosomal localization of a human P2X receptor from the urinary bladder. |journal=Recept. Channels |volume=3 |issue= 4 |pages= 283-9 |year= 1996 |pmid= 8834001 |doi=  }}
*{{cite journal   |vauthors=Clifford EE, Parker K, Humphreys BD, etal |title=The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. |journal=Blood |volume=91 |issue= 9 |pages= 3172–81 |year= 1998 |pmid= 9558372 |doi=  }}
*{{cite journal | author=Clifford EE, Parker K, Humphreys BD, ''et al.'' |title=The P2X1 receptor, an adenosine triphosphate-gated cation channel, is expressed in human platelets but not in human blood leukocytes. |journal=Blood |volume=91 |issue= 9 |pages= 3172-81 |year= 1998 |pmid= 9558372 |doi=  }}
*{{cite journal  | vauthors=Sun B, Li J, Okahara K, Kambayashi J |title=P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11544–7 |year= 1998 |pmid= 9565569 |doi=10.1074/jbc.273.19.11544 }}
*{{cite journal  | author=Sun B, Li J, Okahara K, Kambayashi J |title=P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11544-7 |year= 1998 |pmid= 9565569 |doi=  }}
*{{cite journal   |vauthors=Mulryan K, Gitterman DP, Lewis CJ, etal |title=Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. |journal=Nature |volume=403 |issue= 6765 |pages= 86–9 |year= 2000 |pmid= 10638758 |doi= 10.1038/47495 }}
*{{cite journal | author=Mulryan K, Gitterman DP, Lewis CJ, ''et al.'' |title=Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors. |journal=Nature |volume=403 |issue= 6765 |pages= 86-9 |year= 2000 |pmid= 10638758 |doi= 10.1038/47495 }}
*{{cite journal   |vauthors=Oury C, Toth-Zsamboki E, Van Geet C, etal |title=A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22611–4 |year= 2000 |pmid= 10816552 |doi= 10.1074/jbc.C000305200 }}
*{{cite journal | author=Oury C, Toth-Zsamboki E, Van Geet C, ''et al.'' |title=A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 22611-4 |year= 2000 |pmid= 10816552 |doi= 10.1074/jbc.C000305200 }}
*{{cite journal  | vauthors=Dhulipala PD, Lianos EA, Kotlikoff MI |title=Regulation of human P2X1 promoter activity by beta helix-loop-helix factors in smooth muscle cells. |journal=Gene |volume=269 |issue= 1–2 |pages= 167–75 |year= 2001 |pmid= 11376948 |doi=10.1016/S0378-1119(01)00442-5 }}
*{{cite journal  | author=Dhulipala PD, Lianos EA, Kotlikoff MI |title=Regulation of human P2X1 promoter activity by beta helix-loop-helix factors in smooth muscle cells. |journal=Gene |volume=269 |issue= 1-2 |pages= 167-75 |year= 2001 |pmid= 11376948 |doi=  }}
*{{cite journal  | vauthors=Ennion SJ, Evans RJ |title=Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface |journal=Mol. Pharmacol. |volume=61 |issue= 2 |pages= 303–11 |year= 2002 |pmid= 11809854 |doi=10.1124/mol.61.2.303 }}
*{{cite journal  | author=Ennion SJ, Evans RJ |title=Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface. |journal=Mol. Pharmacol. |volume=61 |issue= 2 |pages= 303-11 |year= 2002 |pmid= 11809854 |doi=  }}
*{{cite journal  | vauthors=Vial C, Rolf MG, Mahaut-Smith MP, Evans RJ |title=A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors |journal=Br. J. Pharmacol. |volume=135 |issue= 2 |pages= 363–72 |year= 2002 |pmid= 11815371 |doi= 10.1038/sj.bjp.0704486 | pmc=1573149 }}
*{{cite journal  | author=Vial C, Rolf MG, Mahaut-Smith MP, Evans RJ |title=A study of P2X1 receptor function in murine megakaryocytes and human platelets reveals synergy with P2Y receptors. |journal=Br. J. Pharmacol. |volume=135 |issue= 2 |pages= 363-72 |year= 2002 |pmid= 11815371 |doi= 10.1038/sj.bjp.0704486 }}
*{{cite journal   |vauthors=Oury C, Toth-Zsamboki E, Thys C, etal |title=The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen |journal=Thromb. Haemost. |volume=86 |issue= 5 |pages= 1264–71 |year= 2003 |pmid= 11816716 |doi=  }}
*{{cite journal | author=Oury C, Toth-Zsamboki E, Thys C, ''et al.'' |title=The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen. |journal=Thromb. Haemost. |volume=86 |issue= 5 |pages= 1264-71 |year= 2003 |pmid= 11816716 |doi=  }}
*{{cite journal   |vauthors=Toth-Zsamboki E, Oury C, Watanabe H, etal |title=The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function |journal=FEBS Lett. |volume=524 |issue= 1–3 |pages= 15–9 |year= 2002 |pmid= 12135734 |doi=10.1016/S0014-5793(02)02987-3 }}
*{{cite journal | author=Toth-Zsamboki E, Oury C, Watanabe H, ''et al.'' |title=The intracellular tyrosine residues of the ATP-gated P2X(1) ion channel are essential for its function. |journal=FEBS Lett. |volume=524 |issue= 1-3 |pages= 15-9 |year= 2002 |pmid= 12135734 |doi=  }}
*{{cite journal  | vauthors=Oury C, Toth-Zsamboki E, Vermylen J, Hoylaerts MF |title=P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen |journal=Blood |volume=100 |issue= 7 |pages= 2499–505 |year= 2002 |pmid= 12239162 |doi= 10.1182/blood-2002-03-0812 }}
*{{cite journal  | author=Oury C, Toth-Zsamboki E, Vermylen J, Hoylaerts MF |title=P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen. |journal=Blood |volume=100 |issue= 7 |pages= 2499-505 |year= 2002 |pmid= 12239162 |doi= 10.1182/blood-2002-03-0812 }}
*{{cite journal  | vauthors=Rolf MG, Mahaut-Smith MP |title=Effects of enhanced P2X1 receptor Ca2+ influx on functional responses in human platelets |journal=Thromb. Haemost. |volume=88 |issue= 3 |pages= 495–502 |year= 2003 |pmid= 12353081 |doi= 10.1267/THRO88030495 }}
*{{cite journal  | author=Rolf MG, Mahaut-Smith MP |title=Effects of enhanced P2X1 receptor Ca2+ influx on functional responses in human platelets. |journal=Thromb. Haemost. |volume=88 |issue= 3 |pages= 495-502 |year= 2003 |pmid= 12353081 |doi= 10.1267/THRO88030495 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Valdecantos P, Briones R, Moya P, etal |title=Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels |journal=Placenta |volume=24 |issue= 1 |pages= 17–26 |year= 2003 |pmid= 12495655 |doi=10.1053/plac.2002.0862 }}
*{{cite journal | author=Valdecantos P, Briones R, Moya P, ''et al.'' |title=Pharmacological identification of P2X1, P2X4 and P2X7 nucleotide receptors in the smooth muscles of human umbilical cord and chorionic blood vessels. |journal=Placenta |volume=24 |issue= 1 |pages= 17-26 |year= 2003 |pmid= 12495655 |doi=  }}
*{{cite journal   |vauthors=Oury C, Kuijpers MJ, Toth-Zsamboki E, etal |title=Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype |journal=Blood |volume=101 |issue= 10 |pages= 3969–76 |year= 2003 |pmid= 12521992 |doi= 10.1182/blood-2002-10-3215 }}
*{{cite journal | author=Oury C, Kuijpers MJ, Toth-Zsamboki E, ''et al.'' |title=Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype. |journal=Blood |volume=101 |issue= 10 |pages= 3969-76 |year= 2003 |pmid= 12521992 |doi= 10.1182/blood-2002-10-3215 }}
*{{cite journal   |vauthors=Wang L, Andersson M, Karlsson L, etal |title=Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with intact endothelium |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 8 |pages= 1370–6 |year= 2004 |pmid= 12791671 |doi= 10.1161/01.ATV.0000080350.37408.5A }}
*{{cite journal | author=Wang L, Andersson M, Karlsson L, ''et al.'' |title=Increased mitogenic and decreased contractile P2 receptors in smooth muscle cells by shear stress in human vessels with intact endothelium. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 8 |pages= 1370-6 |year= 2004 |pmid= 12791671 |doi= 10.1161/01.ATV.0000080350.37408.5A }}
*{{cite journal   |vauthors=Vial C, Pitt SJ, Roberts J, etal |title=Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis |journal=Blood |volume=102 |issue= 10 |pages= 3646–51 |year= 2004 |pmid= 12907444 |doi= 10.1182/blood-2003-06-1963 }}
*{{cite journal | author=Vial C, Pitt SJ, Roberts J, ''et al.'' |title=Lack of evidence for functional ADP-activated human P2X1 receptors supports a role for ATP during hemostasis and thrombosis. |journal=Blood |volume=102 |issue= 10 |pages= 3646-51 |year= 2004 |pmid= 12907444 |doi= 10.1182/blood-2003-06-1963 }}
}}
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{{NLM content}}
{{NLM content}}
{{Ligand-gated ion channels}}
{{Ligand-gated ion channels}}
{{Purinergics}}
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[[Category:Ion channels]]
[[Category:Ion channels]]


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Latest revision as of 17:25, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[1]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[2]

See also

References

  1. ↑ Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels. 3 (4): 283–9. PMID 8834001.
  2. ↑ "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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