Leukemia inhibitory factor receptor

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LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.^[1]

Interactions

Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.^[2]^[3]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

References

↑ "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha".
↑ Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (Jun 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". Eur. J. Biochem. Germany. 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. ISSN 0014-2956. PMID 12047380.
↑ Mosley, B; De Imus C; Friend D; Boiani N; Thoma B; Park L S; Cosman D (Dec 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. UNITED STATES. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. ISSN 0021-9258. PMID 8999038.

Tomida M (2003). "Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells". Leuk. Lymphoma. 37 (5–6): 517–25. doi:10.3109/10428190009058503. PMID 11042511.
Lass A, Weiser W, Munafo A, Loumaye E (2002). "Leukemia inhibitory factor in human reproduction". Fertil. Steril. 76 (6): 1091–6. doi:10.1016/S0015-0282(01)02878-3. PMID 11730732.
Gearing DP, Bruce AG (1992). "Oncostatin M binds the high-affinity leukemia inhibitory factor receptor". New Biol. 4 (1): 61–5. PMID 1536831.
Gearing DP, Comeau MR, Friend DJ, et al. (1992). "The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor". Science. 255 (5050): 1434–7. doi:10.1126/science.1542794. PMID 1542794.
Gearing DP, Thut CJ, VandeBos T, et al. (1991). "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130". EMBO J. 10 (10): 2839–48. PMC 452994. PMID 1915266.
Boulton TG, Stahl N, Yancopoulos GD (1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors". J. Biol. Chem. 269 (15): 11648–55. PMID 7512571.
Schiemann WP, Graves LM, Baumann H, et al. (1995). "Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5361–5. doi:10.1073/pnas.92.12.5361. PMC 41694. PMID 7777512.
Gearing DP, Druck T, Huebner K, et al. (1994). "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13". Genomics. 18 (1): 148–50. doi:10.1006/geno.1993.1441. PMID 8276403.
Sharkey AM, Dellow K, Blayney M, et al. (1996). "Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos". Biol. Reprod. 53 (4): 974–81. doi:10.1095/biolreprod53.4.974. PMID 8547494.
Kojima K, Kanzaki H, Iwai M, et al. (1996). "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts". Hum. Reprod. 10 (7): 1907–11. PMID 8583009.
Tomida M, Gotoh O (1997). "Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor". J. Biochem. 120 (1): 201–5. doi:10.1093/oxfordjournals.jbchem.a021386. PMID 8864865.
Wang Z, Melmed S (1997). "Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage". J. Biol. Chem. 272 (44): 27957–65. doi:10.1074/jbc.272.44.27957. PMID 9346946.
Tanaka M, Hara T, Copeland NG, et al. (1999). "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804–15. PMID 9920829.
Knight DA, Lydell CP, Zhou D, et al. (1999). "Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release". Am. J. Respir. Cell Mol. Biol. 20 (4): 834–41. doi:10.1165/ajrcmb.20.4.3429. PMID 10101017.
Kakizawa T, Miyamoto T, Ichikawa K, et al. (1999). "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
Bartoe JL, Nathanson NM (2000). "Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways". J. Neurochem. 74 (5): 2021–32. doi:10.1046/j.1471-4159.2000.0742021.x. PMID 10800945.
Bamberger AM, Schulte HM, Wullbrand A, et al. (2000). "Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis". Mol. Cell. Endocrinol. 162 (1–2): 145–9. doi:10.1016/S0303-7207(00)00200-8. PMID 10854707.
Blanchard F, Duplomb L, Wang Y, et al. (2000). "Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase". J. Biol. Chem. 275 (37): 28793–801. doi:10.1074/jbc.M003986200. PMID 10858440.
Plun-Favreau H, Elson G, Chabbert M, et al. (2001). "The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine". EMBO J. 20 (7): 1692–703. doi:10.1093/emboj/20.7.1692. PMC 145510. PMID 11285233.

External links

LIF+Receptor+alpha+Subunit at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[entrez-1] "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha".

[pmid12047380-2] Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (Jun 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". Eur. J. Biochem. Germany. 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. ISSN 0014-2956. PMID 12047380.

[pmid8999038-3] Mosley, B; De Imus C; Friend D; Boiani N; Thoma B; Park L S; Cosman D (Dec 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". J. Biol. Chem. UNITED STATES. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. ISSN 0021-9258. PMID 8999038.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Leukemia inhibitory factor receptor

Contents

Interactions

See also

References

Further reading

External links

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