Leukemia inhibitory factor receptor: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
{{redirect-distinguish|LIFR|Low instrument flight rules}}
'''LIFR''' also known as '''CD118''' ('''C'''luster of '''D'''ifferentiation '''118'''),  is a subunit of a receptor for [[leukemia inhibitory factor]].
'''LIFR''' also known as '''CD118''' ('''C'''luster of '''D'''ifferentiation '''118'''),  is a subunit of a receptor for [[leukemia inhibitory factor]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.<ref name="entrez">{{cite web | title = Entrez Gene: LIFR leukemia inhibitory factor receptor alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3977| accessdate = }}</ref>
}}


==Interactions==
The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.<ref name="entrez">{{cite web | title = Entrez Gene: LIFR leukemia inhibitory factor receptor alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3977| accessdate = }}</ref>
Leukemia inhibitory factor receptor has been shown to [[Protein-protein interaction|interact]] with [[Glycoprotein 130]].<ref name=pmid12047380>{{cite journal |vauthors=Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G |date=Jun 2002 |title=A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor |journal=Eur. J. Biochem. |volume=269 |issue=11 |pages=2716–26 |publisher= |location = Germany| issn = 0014-2956| pmid = 12047380 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.1432-1033.2002.02941.x }}</ref><ref name=pmid8999038>{{cite journal |last=Mosley |first=B |authorlink= |author2=De Imus C |author3=Friend D |author4=Boiani N |author5=Thoma B |author6=Park L S |author7=Cosman D |date=Dec 1996 |title=Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation |journal=J. Biol. Chem. |volume=271 |issue=51 |pages=32635–43 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8999038 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.51.32635 }}</ref>
 
== Interactions ==
 
Leukemia inhibitory factor receptor has been shown to [[Protein-protein interaction|interact]] with [[Glycoprotein 130]].<ref name=pmid12047380>{{cite journal | vauthors = Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G | title = A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor | journal = European Journal of Biochemistry | volume = 269 | issue = 11 | pages = 2716–26 | date = June 2002 | pmid = 12047380 | doi = 10.1046/j.1432-1033.2002.02941.x }}</ref><ref name=pmid8999038>{{cite journal | vauthors = Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D | title = Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation | journal = The Journal of Biological Chemistry | volume = 271 | issue = 51 | pages = 32635–43 | date = December 1996 | pmid = 8999038 | doi = 10.1074/jbc.271.51.32635 }}</ref>


LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.
LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.


==See also==
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tomida M | title = Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells | journal = Leukemia & Lymphoma | volume = 37 | issue = 5–6 | pages = 517–25 | date = May 2000 | pmid = 11042511 | doi = 10.3109/10428190009058503 }}
| citations =
* {{cite journal | vauthors = Lass A, Weiser W, Munafo A, Loumaye E | title = Leukemia inhibitory factor in human reproduction | journal = Fertility and Sterility | volume = 76 | issue = 6 | pages = 1091–6 | date = December 2001 | pmid = 11730732 | doi = 10.1016/S0015-0282(01)02878-3 }}
*{{cite journal | author=Tomida M |title=Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells. |journal=Leuk. Lymphoma |volume=37 |issue= 5–6 |pages= 517–25 |year= 2003 |pmid= 11042511 |doi= 10.3109/10428190009058503}}
* {{cite journal | vauthors = Gearing DP, Bruce AG | title = Oncostatin M binds the high-affinity leukemia inhibitory factor receptor | journal = The New Biologist | volume = 4 | issue = 1 | pages = 61–5 | date = January 1992 | pmid = 1536831 | doi =  }}
*{{cite journal |vauthors=Lass A, Weiser W, Munafo A, Loumaye E |title=Leukemia inhibitory factor in human reproduction |journal=Fertil. Steril. |volume=76 |issue= 6 |pages= 1091–6 |year= 2002 |pmid= 11730732 |doi=10.1016/S0015-0282(01)02878-3 }}
* {{cite journal | vauthors = Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B | title = The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor | journal = Science | volume = 255 | issue = 5050 | pages = 1434–7 | date = March 1992 | pmid = 1542794 | doi = 10.1126/science.1542794 }}
*{{cite journal |vauthors=Gearing DP, Bruce AG |title=Oncostatin M binds the high-affinity leukemia inhibitory factor receptor |journal=New Biol. |volume=4 |issue= 1 |pages= 61–5 |year= 1992 |pmid= 1536831 |doi=  }}
* {{cite journal | vauthors = Gearing DP, Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP | title = Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130 | journal = The EMBO Journal | volume = 10 | issue = 10 | pages = 2839–48 | date = October 1991 | pmid = 1915266 | pmc = 452994 | doi =  }}
*{{cite journal   |vauthors=Gearing DP, Comeau MR, Friend DJ, etal |title=The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor |journal=Science |volume=255 |issue= 5050 |pages= 1434–7 |year= 1992 |pmid= 1542794 |doi=10.1126/science.1542794 }}
* {{cite journal | vauthors = Boulton TG, Stahl N, Yancopoulos GD | title = Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors | journal = The Journal of Biological Chemistry | volume = 269 | issue = 15 | pages = 11648–55 | date = April 1994 | pmid = 7512571 | doi =  }}
*{{cite journal   |vauthors=Gearing DP, Thut CJ, VandeBos T, etal |title=Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130 |journal=EMBO J. |volume=10 |issue= 10 |pages= 2839–48 |year= 1991 |pmid= 1915266 |doi= | pmc=452994 }}
* {{cite journal | vauthors = Schiemann WP, Graves LM, Baumann H, Morella KK, Gearing DP, Nielsen MD, Krebs EG, Nathanson NM | title = Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 12 | pages = 5361–5 | date = June 1995 | pmid = 7777512 | pmc = 41694 | doi = 10.1073/pnas.92.12.5361 }}
*{{cite journal |vauthors=Boulton TG, Stahl N, Yancopoulos GD |title=Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors |journal=J. Biol. Chem. |volume=269 |issue= 15 |pages= 11648–55 |year= 1994 |pmid= 7512571 |doi=  }}
* {{cite journal | vauthors = Gearing DP, Druck T, Huebner K, Overhauser J, Gilbert DJ, Copeland NG, Jenkins NA | title = The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13 | journal = Genomics | volume = 18 | issue = 1 | pages = 148–50 | date = October 1993 | pmid = 8276403 | doi = 10.1006/geno.1993.1441 }}
*{{cite journal   |vauthors=Schiemann WP, Graves LM, Baumann H, etal |title=Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 12 |pages= 5361–5 |year= 1995 |pmid= 7777512 |doi=10.1073/pnas.92.12.5361 | pmc=41694  }}
* {{cite journal | vauthors = Sharkey AM, Dellow K, Blayney M, Macnamee M, Charnock-Jones S, Smith SK | title = Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos | journal = Biology of Reproduction | volume = 53 | issue = 4 | pages = 974–81 | date = October 1995 | pmid = 8547494 | doi = 10.1095/biolreprod53.4.974 }}
*{{cite journal   |vauthors=Gearing DP, Druck T, Huebner K, etal |title=The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13 |journal=Genomics |volume=18 |issue= 1 |pages= 148–50 |year= 1994 |pmid= 8276403 |doi= 10.1006/geno.1993.1441 }}
* {{cite journal | vauthors = Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Narukawa S, Higuchi T, Kaneko Y, Mori T, Fujita J | title = Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts | journal = Human Reproduction | volume = 10 | issue = 7 | pages = 1907–11 | date = July 1995 | pmid = 8583009 | doi =  }}
*{{cite journal   |vauthors=Sharkey AM, Dellow K, Blayney M, etal |title=Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos |journal=Biol. Reprod. |volume=53 |issue= 4 |pages= 974–81 |year= 1996 |pmid= 8547494 |doi=10.1095/biolreprod53.4.974 }}
* {{cite journal | vauthors = Tomida M, Gotoh O | title = Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor | journal = Journal of Biochemistry | volume = 120 | issue = 1 | pages = 201–5 | date = July 1996 | pmid = 8864865 | doi = 10.1093/oxfordjournals.jbchem.a021386 }}
*{{cite journal   |vauthors=Kojima K, Kanzaki H, Iwai M, etal |title=Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts |journal=Hum. Reprod. |volume=10 |issue= 7 |pages= 1907–11 |year= 1996 |pmid= 8583009 |doi=  }}
* {{cite journal | vauthors = Wang Z, Melmed S | title = Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27957–65 | date = October 1997 | pmid = 9346946 | doi = 10.1074/jbc.272.44.27957 }}
*{{cite journal |vauthors=Tomida M, Gotoh O |title=Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor |journal=J. Biochem. |volume=120 |issue= 1 |pages= 201–5 |year= 1997 |pmid= 8864865 |doi= 10.1093/oxfordjournals.jbchem.a021386}}
* {{cite journal | vauthors = Tanaka M, Hara T, Copeland NG, Gilbert DJ, Jenkins NA, Miyajima A | title = Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit | journal = Blood | volume = 93 | issue = 3 | pages = 804–15 | date = February 1999 | pmid = 9920829 | doi =  }}
*{{cite journal |vauthors=Wang Z, Melmed S |title=Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27957–65 |year= 1997 |pmid= 9346946 |doi=10.1074/jbc.272.44.27957 }}
* {{cite journal | vauthors = Knight DA, Lydell CP, Zhou D, Weir TD, Robert Schellenberg R, Bai TR | title = Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 20 | issue = 4 | pages = 834–41 | date = April 1999 | pmid = 10101017 | doi = 10.1165/ajrcmb.20.4.3429 }}
*{{cite journal   |vauthors=Tanaka M, Hara T, Copeland NG, etal |title=Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit |journal=Blood |volume=93 |issue= 3 |pages= 804–15 |year= 1999 |pmid= 9920829 |doi=  }}
* {{cite journal | vauthors = Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori JI, Kumagai M, Hashizume K | title = Functional interaction between Oct-1 and retinoid X receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19103–8 | date = July 1999 | pmid = 10383413 | doi = 10.1074/jbc.274.27.19103 }}
*{{cite journal   |vauthors=Knight DA, Lydell CP, Zhou D, etal |title=Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release |journal=Am. J. Respir. Cell Mol. Biol. |volume=20 |issue= 4 |pages= 834–41 |year= 1999 |pmid= 10101017 |doi= 10.1165/ajrcmb.20.4.3429}}
* {{cite journal | vauthors = Bartoe JL, Nathanson NM | title = Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways | journal = Journal of Neurochemistry | volume = 74 | issue = 5 | pages = 2021–32 | date = May 2000 | pmid = 10800945 | doi = 10.1046/j.1471-4159.2000.0742021.x }}
*{{cite journal   |vauthors=Kakizawa T, Miyamoto T, Ichikawa K, etal |title=Functional interaction between Oct-1 and retinoid X receptor |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19103–8 |year= 1999 |pmid= 10383413 |doi=10.1074/jbc.274.27.19103 }}
* {{cite journal | vauthors = Bamberger AM, Schulte HM, Wullbrand A, Jung R, Beil FU, Bamberger CM | title = Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis | journal = Molecular and Cellular Endocrinology | volume = 162 | issue = 1–2 | pages = 145–9 | date = April 2000 | pmid = 10854707 | doi = 10.1016/S0303-7207(00)00200-8 }}
*{{cite journal |vauthors=Bartoe JL, Nathanson NM |title=Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways |journal=J. Neurochem. |volume=74 |issue= 5 |pages= 2021–32 |year= 2000 |pmid= 10800945 |doi=10.1046/j.1471-4159.2000.0742021.x }}
* {{cite journal | vauthors = Blanchard F, Duplomb L, Wang Y, Robledo O, Kinzie E, Pitard V, Godard A, Jacques Y, Baumann H | title = Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 37 | pages = 28793–801 | date = September 2000 | pmid = 10858440 | doi = 10.1074/jbc.M003986200 }}
*{{cite journal   |vauthors=Bamberger AM, Schulte HM, Wullbrand A, etal |title=Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis |journal=Mol. Cell. Endocrinol. |volume=162 |issue= 1–2 |pages= 145–9 |year= 2000 |pmid= 10854707 |doi=10.1016/S0303-7207(00)00200-8 }}
* {{cite journal | vauthors = Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S | title = The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine | journal = The EMBO Journal | volume = 20 | issue = 7 | pages = 1692–703 | date = April 2001 | pmid = 11285233 | pmc = 145510 | doi = 10.1093/emboj/20.7.1692 }}
*{{cite journal   |vauthors=Blanchard F, Duplomb L, Wang Y, etal |title=Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28793–801 |year= 2000 |pmid= 10858440 |doi= 10.1074/jbc.M003986200 }}
*{{cite journal   |vauthors=Plun-Favreau H, Elson G, Chabbert M, etal |title=The ciliary neurotrophic factor receptor α component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine |journal=EMBO J. |volume=20 |issue= 7 |pages= 1692–703 |year= 2001 |pmid= 11285233 |doi= 10.1093/emboj/20.7.1692 | pmc=145510 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|LIF+Receptor+alpha+Subunit}}
* {{MeshName|LIF+Receptor+alpha+Subunit}}


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{{Cytokine receptor modulators}}
{{Cytokine receptor modulators}}


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[[Category:Type I cytokine receptors]]
[[Category:Type I cytokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]


{{membrane-protein-stub}}
{{membrane-protein-stub}}

Latest revision as of 22:37, 29 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
"LIFR" redirects here. It is not to be confused with Low instrument flight rules.

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

Function

The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.[1]

Interactions

Leukemia inhibitory factor receptor has been shown to interact with Glycoprotein 130.[2][3]

LIFR has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.

See also

References

  1. ↑ "Entrez Gene: LIFR leukemia inhibitory factor receptor alpha".
  2. ↑ Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (June 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". European Journal of Biochemistry. 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. PMID 12047380.
  3. ↑ Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". The Journal of Biological Chemistry. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.

Further reading

  • Tomida M (May 2000). "Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells". Leukemia & Lymphoma. 37 (5–6): 517–25. doi:10.3109/10428190009058503. PMID 11042511.
  • Lass A, Weiser W, Munafo A, Loumaye E (December 2001). "Leukemia inhibitory factor in human reproduction". Fertility and Sterility. 76 (6): 1091–6. doi:10.1016/S0015-0282(01)02878-3. PMID 11730732.
  • Gearing DP, Bruce AG (January 1992). "Oncostatin M binds the high-affinity leukemia inhibitory factor receptor". The New Biologist. 4 (1): 61–5. PMID 1536831.
  • Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B (March 1992). "The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor". Science. 255 (5050): 1434–7. doi:10.1126/science.1542794. PMID 1542794.
  • Gearing DP, Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP (October 1991). "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130". The EMBO Journal. 10 (10): 2839–48. PMC 452994. PMID 1915266.
  • Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors". The Journal of Biological Chemistry. 269 (15): 11648–55. PMID 7512571.
  • Schiemann WP, Graves LM, Baumann H, Morella KK, Gearing DP, Nielsen MD, Krebs EG, Nathanson NM (June 1995). "Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". Proceedings of the National Academy of Sciences of the United States of America. 92 (12): 5361–5. doi:10.1073/pnas.92.12.5361. PMC 41694. PMID 7777512.
  • Gearing DP, Druck T, Huebner K, Overhauser J, Gilbert DJ, Copeland NG, Jenkins NA (October 1993). "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13". Genomics. 18 (1): 148–50. doi:10.1006/geno.1993.1441. PMID 8276403.
  • Sharkey AM, Dellow K, Blayney M, Macnamee M, Charnock-Jones S, Smith SK (October 1995). "Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos". Biology of Reproduction. 53 (4): 974–81. doi:10.1095/biolreprod53.4.974. PMID 8547494.
  • Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Narukawa S, Higuchi T, Kaneko Y, Mori T, Fujita J (July 1995). "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts". Human Reproduction. 10 (7): 1907–11. PMID 8583009.
  • Tomida M, Gotoh O (July 1996). "Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor". Journal of Biochemistry. 120 (1): 201–5. doi:10.1093/oxfordjournals.jbchem.a021386. PMID 8864865.
  • Wang Z, Melmed S (October 1997). "Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage". The Journal of Biological Chemistry. 272 (44): 27957–65. doi:10.1074/jbc.272.44.27957. PMID 9346946.
  • Tanaka M, Hara T, Copeland NG, Gilbert DJ, Jenkins NA, Miyajima A (February 1999). "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804–15. PMID 9920829.
  • Knight DA, Lydell CP, Zhou D, Weir TD, Robert Schellenberg R, Bai TR (April 1999). "Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 834–41. doi:10.1165/ajrcmb.20.4.3429. PMID 10101017.
  • Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori JI, Kumagai M, Hashizume K (July 1999). "Functional interaction between Oct-1 and retinoid X receptor". The Journal of Biological Chemistry. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
  • Bartoe JL, Nathanson NM (May 2000). "Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways". Journal of Neurochemistry. 74 (5): 2021–32. doi:10.1046/j.1471-4159.2000.0742021.x. PMID 10800945.
  • Bamberger AM, Schulte HM, Wullbrand A, Jung R, Beil FU, Bamberger CM (April 2000). "Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis". Molecular and Cellular Endocrinology. 162 (1–2): 145–9. doi:10.1016/S0303-7207(00)00200-8. PMID 10854707.
  • Blanchard F, Duplomb L, Wang Y, Robledo O, Kinzie E, Pitard V, Godard A, Jacques Y, Baumann H (September 2000). "Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase". The Journal of Biological Chemistry. 275 (37): 28793–801. doi:10.1074/jbc.M003986200. PMID 10858440.
  • Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S (April 2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine". The EMBO Journal. 20 (7): 1692–703. doi:10.1093/emboj/20.7.1692. PMC 145510. PMID 11285233.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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