CCR8 (gene): Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Chemokine (C-C motif) receptor 8''', also known as '''CCR8''', is a [[protein]] which in humans is encoded by the ''CCR8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR8 chemokine (C-C motif) receptor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1237| accessdate = }}</ref> CCR8 has also recently been designated '''CDw198''' ([[cluster of differentiation]] w198).
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| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) receptor 8
| HGNCid = 1609
| Symbol = CCR8
| AltSymbols =; CDw198; CKR-L1; CKRL1; CMKBR8; CMKBRL2; CY6; GPR-CY6; MGC129966; MGC129973; TER1
| OMIM = 601834
| ECnumber = 
| Homologene = 21080
| MGIid = 1201402
| GeneAtlas_image1 = PBB_GE_CCR8_208059_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1237
    | Hs_Ensembl = ENSG00000179934
    | Hs_RefseqProtein = NP_005192
    | Hs_RefseqmRNA = NM_005201
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 39346219
    | Hs_GenLoc_end = 39351077
    | Hs_Uniprot = P51685
    | Mm_EntrezGene = 12776
    | Mm_Ensembl = ENSMUSG00000042262
    | Mm_RefseqmRNA = XM_986843
    | Mm_RefseqProtein = XP_991937
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 119940831
    | Mm_GenLoc_end = 119943604
    | Mm_Uniprot = Q27VK4
  }}
}}
'''Chemokine (C-C motif) receptor 8''', also known as '''CCR8''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR8 chemokine (C-C motif) receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1237| accessdate = }}</ref>


CCR8 has also recently been designated '''CDw198''' ([[cluster of differentiation]] w198).
This gene encodes a member of the beta [[chemokine receptor]] family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the [[thymus]]. The ligand of the CCR8 is [[CCL1]].<ref name="pmid10540332">{{cite journal | vauthors = Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP | title = The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8 | journal = Eur. J. Immunol. | volume = 29 | issue = 10 | pages = 3210–5  | date = October 1999 | pmid = 10540332 | doi = 10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W }}</ref> CCL8 also functions as a CCR8 agonist.<ref name="pmid21217759">{{cite journal | vauthors = Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD | title = Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells | journal = Nat. Immunol. | volume = 12 | issue = 2 | pages = 167–77 | year = 2011 | pmid = 21217759 | pmc = 3863381 | doi = 10.1038/ni.1984 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and [[thymocyte|thymic cell]] [[apoptosis]]. More specifically, this receptor may contribute to the proper positioning of activated [[T cell]]s within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.<ref name="entrez">{{cite web | title = Entrez Gene: CCR8 chemokine (C-C motif) receptor 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1237| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[CC chemokine receptors]]
* [[CC chemokine receptors]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== External links ==
* {{UCSC gene info|CCR8}}
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2234 | title = Chemokine Receptors: CCR8 | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM | title = HIV-1 infection and chemokine receptor modulation | journal = Curr. HIV Res. | volume = 2 | issue = 1 | pages = 39–50 | year = 2004 | pmid = 15053339 | doi = 10.2174/1570162043484997 }}
| citations =
* {{cite journal | vauthors = Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A | title = Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues | journal = J. Immunol. | volume = 157 | issue = 7 | pages = 2759–63 | year = 1996 | pmid = 8816377 | doi =  }}
*{{cite journal | author=Ruibal-Ares BH, Belmonte L, Baré PC, ''et al.'' |title=HIV-1 infection and chemokine receptor modulation. |journal=Curr. HIV Res. |volume=2 |issue= 1 |pages= 39-50 |year= 2004 |pmid= 15053339 |doi= }}
* {{cite journal | vauthors = Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G | title = Molecular cloning and RNA expression of two new human chemokine receptor-like genes | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 3 | pages = 846–53 | year = 1996 | pmid = 8886020 | doi = 10.1006/bbrc.1996.1595 }}
*{{cite journal | author=Napolitano M, Zingoni A, Bernardini G, ''et al.'' |title=Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. |journal=J. Immunol. |volume=157 |issue= 7 |pages= 2759-63 |year= 1996 |pmid= 8816377 |doi=  }}
* {{cite journal | vauthors = Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M | title = Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor | journal = Eur. J. Immunol. | volume = 26 | issue = 12 | pages = 3021–8 | year = 1996 | pmid = 8977299 | doi = 10.1002/eji.1830261230 }}
*{{cite journal | author=Zaballos A, Varona R, Gutiérrez J, ''et al.'' |title=Molecular cloning and RNA expression of two new human chemokine receptor-like genes. |journal=Biochem. Biophys. Res. Commun. |volume=227 |issue= 3 |pages= 846-53 |year= 1996 |pmid= 8886020 |doi= 10.1006/bbrc.1996.1595 }}
* {{cite journal | vauthors = Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM | title = Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309 | journal = J. Exp. Med. | volume = 186 | issue = 1 | pages = 165–70 | year = 1997 | pmid = 9207005 | pmc = 2198957 | doi = 10.1084/jem.186.1.165 }}
*{{cite journal | author=Samson M, Stordeur P, Labbé O, ''et al.'' |title=Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor. |journal=Eur. J. Immunol. |volume=26 |issue= 12 |pages= 3021-8 |year= 1997 |pmid= 8977299 |doi= }}
* {{cite journal | vauthors = Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B | title = Identification of CCR8, the receptor for the human CC chemokine I-309 | journal = J. Biol. Chem. | volume = 272 | issue = 28 | pages = 17251–4 | year = 1997 | pmid = 9211859 | doi = 10.1074/jbc.272.28.17251 }}
*{{cite journal | author=Tiffany HL, Lautens LL, Gao JL, ''et al.'' |title=Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. |journal=J. Exp. Med. |volume=186 |issue= 1 |pages= 165-70 |year= 1997 |pmid= 9207005 |doi= }}
* {{cite journal | vauthors = Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW | title = The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains | journal = J. Biol. Chem. | volume = 273 | issue = 1 | pages = 386–91 | year = 1998 | pmid = 9417093 | doi = 10.1074/jbc.273.1.386 }}
*{{cite journal | author=Roos RS, Loetscher M, Legler DF, ''et al.'' |title=Identification of CCR8, the receptor for the human CC chemokine I-309. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17251-4 |year= 1997 |pmid= 9211859 |doi= }}
* {{cite journal | vauthors = Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G | title = Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3 | journal = J. Immunol. | volume = 160 | issue = 4 | pages = 1975–81 | year = 1998 | pmid = 9469461 | doi =  }}
*{{cite journal | author=Horuk R, Hesselgesser J, Zhou Y, ''et al.'' |title=The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 386-91 |year= 1998 |pmid= 9417093 |doi= }}
* {{cite journal | vauthors = Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H | title = Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 497–502 | year = 1998 | pmid = 9480837 | doi = 10.1006/bbrc.1998.8130 }}
*{{cite journal | author=Goya I, Gutiérrez J, Varona R, ''et al.'' |title=Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3. |journal=J. Immunol. |volume=160 |issue= 4 |pages= 1975-81 |year= 1998 |pmid= 9469461 |doi=  }}
* {{cite journal | vauthors = Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano M | title = Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor | journal = Eur. J. Immunol. | volume = 28 | issue = 2 | pages = 582–8 | year = 1998 | pmid = 9521068 | doi = 10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A }}
*{{cite journal | author=Jinno A, Shimizu N, Soda Y, ''et al.'' |title=Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 497-502 |year= 1998 |pmid= 9480837 |doi= 10.1006/bbrc.1998.8130 }}
* {{cite journal | vauthors = Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlazzi CT, Sinigaglia F, D'Ambrosio D, O'Garra A, Robinson D, Rocchi M, Santoni A, Zlotnik A, Napolitano M | title = The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells | journal = J. Immunol. | volume = 161 | issue = 2 | pages = 547–51 | year = 1998 | pmid = 9670926 | doi =  }}
*{{cite journal | author=Bernardini G, Hedrick J, Sozzani S, ''et al.'' |title=Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. |journal=Eur. J. Immunol. |volume=28 |issue= 2 |pages= 582-8 |year= 1998 |pmid= 9521068 |doi= }}
* {{cite journal | vauthors = Efremov R, Truong MJ, Darcissac EC, Zeng J, Grau O, Vergoten G, Debard C, Capron A, Bahr GM | title = Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function | journal = Eur. J. Biochem. | volume = 263 | issue = 3 | pages = 746–56 | year = 1999 | pmid = 10469138 | doi = 10.1046/j.1432-1327.1999.00553.x }}
*{{cite journal | author=Zingoni A, Soto H, Hedrick JA, ''et al.'' |title=The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells. |journal=J. Immunol. |volume=161 |issue= 2 |pages= 547-51 |year= 1998 |pmid= 9670926 |doi=  }}
* {{cite journal | vauthors = Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP | title = The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8 | journal = Eur. J. Immunol. | volume = 29 | issue = 10 | pages = 3210–5 | year = 1999 | pmid = 10540332 | doi = 10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W }}
*{{cite journal | author=Efremov R, Truong MJ, Darcissac EC, ''et al.'' |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746-56 |year= 1999 |pmid= 10469138 |doi= }}
* {{cite journal | vauthors = Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB | title = CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor | journal = J. Virol. | volume = 74 | issue = 15 | pages = 6946–52 | year = 2000 | pmid = 10888633 | pmc = 112211 | doi = 10.1128/JVI.74.15.6946-6952.2000 }}
*{{cite journal | author=Garlisi CG, Xiao H, Tian F, ''et al.'' |title=The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8. |journal=Eur. J. Immunol. |volume=29 |issue= 10 |pages= 3210-5 |year= 1999 |pmid= 10540332 |doi= }}
* {{cite journal | vauthors = Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ | title = LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8 | journal = Blood | volume = 96 | issue = 3 | pages = 840–5 | year = 2000 | pmid = 10910894 | doi =  }}
*{{cite journal | author=Lee S, Tiffany HL, King L, ''et al.'' |title=CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor. |journal=J. Virol. |volume=74 |issue= 15 |pages= 6946-52 |year= 2000 |pmid= 10888633 |doi= }}
* {{cite journal | vauthors = Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K, Yee IC, Fellows F, Kelvin D, Bhatia M | title = Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny | journal = Stem Cells | volume = 18 | issue = 5 | pages = 374–81 | year = 2000 | pmid = 11007922 | doi = 10.1634/stemcells.18-5-374 }}
*{{cite journal | author=Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ |title=LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8. |journal=Blood |volume=96 |issue= 3 |pages= 840-5 |year= 2000 |pmid= 10910894 |doi=  }}
* {{cite journal | vauthors = Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D, Pisell T, Tangmunkongvorakul A, Kamtorn N, Nantachit N, Nagachinta T, Suriyanon V, Robison V, Nelson KE, Sittisombut N, Lal RB | title = Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives | journal = AIDS Res. Hum. Retroviruses | volume = 18 | issue = 1 | pages = 1–11 | year = 2002 | pmid = 11804551 | doi = 10.1089/088922202753394664 }}
*{{cite journal | author=Rosu-Myles M, Khandaker M, Wu DM, ''et al.'' |title=Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny. |journal=Stem Cells |volume=18 |issue= 5 |pages= 374-81 |year= 2000 |pmid= 11007922 |doi= }}
* {{cite journal | vauthors = Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S | title = Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes | journal = J. Exp. Med. | volume = 196 | issue = 3 | pages = 379–87 | year = 2002 | pmid = 12163566 | pmc = 2193942 | doi = 10.1084/jem.20020110 }}
*{{cite journal | author=Utaipat U, Duerr A, Rudolph DL, ''et al.'' |title=Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11804551 |doi= 10.1089/088922202753394664 }}
* {{cite journal | vauthors = Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M | title = The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway | journal = J. Leukoc. Biol. | volume = 73 | issue = 1 | pages = 201–7 | year = 2003 | pmid = 12525579 | doi = 10.1189/jlb.0302105 }}
*{{cite journal | author=Annunziato F, Cosmi L, Liotta F, ''et al.'' |title=Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. |journal=J. Exp. Med. |volume=196 |issue= 3 |pages= 379-87 |year= 2002 |pmid= 12163566 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Spinetti G, Bernardini G, Camarda G, ''et al.'' |title=The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway. |journal=J. Leukoc. Biol. |volume=73 |issue= 1 |pages= 201-7 |year= 2003 |pmid= 12525579 |doi=  }}
}}
{{refend}}
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[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Revision as of 09:19, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.[1] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.[2] CCL8 also functions as a CCR8 agonist.[3]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8".
  2. ↑ Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
  3. ↑ Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD (2011). "Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells". Nat. Immunol. 12 (2): 167–77. doi:10.1038/ni.1984. PMC 3863381. PMID 21217759.

External links

Further reading

  • Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
  • Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A (1996). "Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues". J. Immunol. 157 (7): 2759–63. PMID 8816377.
  • Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020.
  • Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M (1996). "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor". Eur. J. Immunol. 26 (12): 3021–8. doi:10.1002/eji.1830261230. PMID 8977299.
  • Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM (1997). "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309". J. Exp. Med. 186 (1): 165–70. doi:10.1084/jem.186.1.165. PMC 2198957. PMID 9207005.
  • Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
  • Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW (1998). "The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains". J. Biol. Chem. 273 (1): 386–91. doi:10.1074/jbc.273.1.386. PMID 9417093.
  • Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G (1998). "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3". J. Immunol. 160 (4): 1975–81. PMID 9469461.
  • Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H (1998). "Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection". Biochem. Biophys. Res. Commun. 243 (2): 497–502. doi:10.1006/bbrc.1998.8130. PMID 9480837.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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