Bradykinin receptor B2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{DISPLAYTITLE:Bradykinin receptor B<sub>2</sub>}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Bradykinin receptor B<sub>2</sub>''' is a [[G-protein coupled receptor]] for [[bradykinin]], encoded by the '''BDKRB2''' [[gene]] in humans.
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Bradykinin receptor B2
| HGNCid = 1030
| Symbol = BDKRB2
| AltSymbols =; B2R; BK-2; BK2; BKR2; BRB2; DKFZp686O088
| OMIM = 113503
| ECnumber = 
| Homologene = 519
| MGIid = 102845
| GeneAtlas_image1 = PBB_GE_BDKRB2_205870_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004947 |text = bradykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0008015 |text = circulation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 624
    | Hs_Ensembl = ENSG00000168398
    | Hs_RefseqProtein = NP_000614
    | Hs_RefseqmRNA = NM_000623
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 95740950
    | Hs_GenLoc_end = 95780536
    | Hs_Uniprot = P30411
    | Mm_EntrezGene = 12062
    | Mm_Ensembl = ENSMUSG00000021070
    | Mm_RefseqmRNA = NM_009747
    | Mm_RefseqProtein = NP_033877
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 105964222
    | Mm_GenLoc_end = 105994121
    | Mm_Uniprot = P32299
  }}
}}
'''Bradykinin receptor B2''', also known as '''BDKRB2''', is a [[bradykinin receptor]], but also denotes the human [[gene]] encoding it.


==Mechanism==
==Mechanism==
The B2 receptor is a [[G protein-coupled receptor]], probably coupled to [[Gq alpha subunit|G<sub>q</sub>]] and [[Gi alpha subunit|G<sub>i</sub>]]. G<sub>q</sub> stimulates [[phospholipase C]] to increase [[intracellular]] free [[calcium]] and G<sub>i</sub> inhibits [[adenylate cyclase]]. Furthermore, the receptor stimulates the [[mitogen-activated protein kinase]] pathways. It is ubiquitously and constitutively expressed in healthy tissues.
The B<sub>2</sub> receptor is a [[G protein-coupled receptor]], probably coupled to [[Gq alpha subunit|G<sub>q</sub>]] and [[Gi alpha subunit|G<sub>i</sub>]]. G<sub>q</sub> stimulates [[phospholipase C]] to increase [[intracellular]] free [[calcium]] and G<sub>i</sub> inhibits [[adenylate cyclase]]. Furthermore, the receptor stimulates the [[mitogen-activated protein kinase]] pathways. It is ubiquitously and constitutively expressed in healthy tissues.


The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin 1-7 (A1-7) also potentiates bradykinin action on B2 receptors.<ref name="pmid11230360">{{cite journal | author = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = | issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 }}</ref>
The B<sub>2</sub> receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide [[angiotensin (1-7)]] also potentiates bradykinin action on B<sub>2</sub> receptors.<ref name="pmid11230360">{{cite journal | vauthors = Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH | title = Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo | journal = Hypertension | volume = 37 | issue = 2 Part 2 | pages = 703–9 | year = 2001 | pmid = 11230360 | doi = 10.1161/01.hyp.37.2.703| issn = | url = http://hyper.ahajournals.org/cgi/content/abstract/37/2/703 }}</ref>


[[Kallidin]] also signals through the B2 receptor.  
[[Kallidin]] also signals through the B<sub>2</sub> receptor. An antagonist for the receptor is Hoe 140 ([[icatibant]]).<ref>{{Cite journal|title = Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies | pmc=1917928 | pmid=1364852 | volume=102 | year=1991 | journal=Br. J. Pharmacol. | pages=774–7 | vauthors=Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henk S, Breipohl G, König W, Knolle J | doi=10.1111/j.1476-5381.1991.tb12249.x}}</ref>


==Function==
==Function==
Line 59: Line 14:


==Gene==
==Gene==
Alternate start codons result in two isoforms of the protein.<ref name="entrez">{{cite web | title = Entrez Gene: BDKRB2 bradykinin receptor B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=624| accessdate = }}</ref>
Alternate start codons result in two isoforms of the protein.<ref name="entrez">{{cite web | title = Entrez Gene: BDKRB2 bradykinin receptor B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=624| accessdate = }}</ref>


==See also==
==See also==
Line 65: Line 20:


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2976 | title = Bradykinin Receptors: B<sub>2</sub>  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|BDKRB2}}


==Further reading==
==Further reading==
Line 71: Line 30:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Duchêne J, Schanstra J, Cellier E, ''et al.'' |title=[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39-41 |year= 2002 |pmid= 11908480 |doi=  }}
*{{cite journal  | vauthors=Duchêne J, Schanstra J, Cellier E |title=[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway] |journal=Néphrologie |volume=23 |issue= 1 |pages= 39–41 |year= 2002 |pmid= 11908480 |doi=  |display-authors=etal}}
*{{cite journal  | author=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48-56 |year= 2007 |pmid= 17569300 |doi=  }}
*{{cite journal  | vauthors=Ariza AC, Bobadilla NA, Halhali A |title=[Endothelin 1 and angiotensin II in preeeclampsia] |journal=Rev. Invest. Clin. |volume=59 |issue= 1 |pages= 48–56 |year= 2007 |pmid= 17569300 |doi=  }}
*{{cite journal  | author=Hess JF, Borkowski JA, Young GS, ''et al.'' |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260-8 |year= 1992 |pmid= 1314587 |doi=  }}
*{{cite journal  | vauthors=Hess JF, Borkowski JA, Young GS |title=Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 1 |pages= 260–8 |year= 1992 |pmid= 1314587 |doi=10.1016/0006-291X(92)91187-U |display-authors=etal}}
*{{cite journal  | author=Eggerickx D, Raspe E, Bertrand D, ''et al.'' |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306-13 |year= 1992 |pmid= 1329734 |doi=  }}
*{{cite journal  | vauthors=Eggerickx D, Raspe E, Bertrand D |title=Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1306–13 |year= 1992 |pmid= 1329734 |doi=10.1016/0006-291X(92)90445-Q |display-authors=etal}}
*{{cite journal  | author=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226-33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800 }}
*{{cite journal  | vauthors=Kammerer S, Braun A, Arnold N, Roscher AA |title=The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 226–33 |year= 1995 |pmid= 7779089 |doi= 10.1006/bbrc.1995.1800 }}
*{{cite journal  | author=Braun A, Kammerer S, Böhme E, ''et al.'' |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234-40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801 }}
*{{cite journal  | vauthors=Braun A, Kammerer S, Böhme E |title=Identification of polymorphic sites of the human bradykinin B2 receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 234–40 |year= 1995 |pmid= 7779090 |doi= 10.1006/bbrc.1995.1801 |display-authors=etal}}
*{{cite journal  | author=Ma JX, Wang DZ, Ward DC, ''et al.'' |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362-9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512 }}
*{{cite journal  | vauthors=Ma JX, Wang DZ, Ward DC |title=Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor. |journal=Genomics |volume=23 |issue= 2 |pages= 362–9 |year= 1995 |pmid= 7835885 |doi= 10.1006/geno.1994.1512 |display-authors=etal}}
*{{cite journal  | author=Powell SJ, Slynn G, Thomas C, ''et al.'' |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435-8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084 }}
*{{cite journal  | vauthors=Powell SJ, Slynn G, Thomas C |title=Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14. |journal=Genomics |volume=15 |issue= 2 |pages= 435–8 |year= 1993 |pmid= 7916737 |doi= 10.1006/geno.1993.1084 |display-authors=etal}}
*{{cite journal  | author=Menke JG, Borkowski JA, Bierilo KK, ''et al.'' |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583-6 |year= 1994 |pmid= 8063797 |doi=  }}
*{{cite journal  | vauthors=Menke JG, Borkowski JA, Bierilo KK |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=  |display-authors=etal}}
*{{cite journal  | author=Hess JF, Borkowski JA, Macneil T, ''et al.'' |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1-8 |year= 1994 |pmid= 8302267 |doi=  }}
*{{cite journal  | vauthors=Hess JF, Borkowski JA, Macneil T |title=Differential pharmacology of cloned human and mouse B2 bradykinin receptors. |journal=Mol. Pharmacol. |volume=45 |issue= 1 |pages= 1–8 |year= 1994 |pmid= 8302267 |doi=  |display-authors=etal}}
*{{cite journal  | author=McIntyre P, Phillips E, Skidmore E, ''et al.'' |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346-55 |year= 1993 |pmid= 8394991 |doi=  }}
*{{cite journal  | vauthors=McIntyre P, Phillips E, Skidmore E |title=Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity. |journal=Mol. Pharmacol. |volume=44 |issue= 2 |pages= 346–55 |year= 1993 |pmid= 8394991 |doi=  |display-authors=etal}}
*{{cite journal  | author=AbdAlla S, Godovac-Zimmermann J, Braun A, ''et al.'' |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514-9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060 }}
*{{cite journal  | vauthors=AbdAlla S, Godovac-Zimmermann J, Braun A |title=Structure of the bradykinin B2 receptors' amino terminus. |journal=Biochemistry |volume=35 |issue= 23 |pages= 7514–9 |year= 1996 |pmid= 8652530 |doi= 10.1021/bi9601060 |display-authors=etal}}
*{{cite journal  | author=Isami S, Kishikawa H, Araki E, ''et al.'' |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412-20 |year= 1996 |pmid= 8777990 |doi=  }}
*{{cite journal  | vauthors=Isami S, Kishikawa H, Araki E |title=Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway. |journal=Diabetologia |volume=39 |issue= 4 |pages= 412–20 |year= 1996 |pmid= 8777990 |doi=10.1007/BF00400672 |display-authors=etal}}
*{{cite journal  | author=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236-44 |year= 1996 |pmid= 8900488 |doi=  }}
*{{cite journal  | vauthors=Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL |title=Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms. |journal=Eur. J. Cell Biol. |volume=69 |issue= 3 |pages= 236–44 |year= 1996 |pmid= 8900488 |doi=  }}
*{{cite journal  | author=Soskic V, Nyakatura E, Roos M, ''et al.'' |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539-45 |year= 1999 |pmid= 10085087 |doi=  }}
*{{cite journal  | vauthors=Soskic V, Nyakatura E, Roos M |title=Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8539–45 |year= 1999 |pmid= 10085087 |doi=10.1074/jbc.274.13.8539 |display-authors=etal}}
*{{cite journal  | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239-44 |year= 1999 |pmid= 10188626 |doi=  }}
*{{cite journal  | vauthors=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=10.1016/S0306-3623(98)00275-4 }}
*{{cite journal  | author=Efremov R, Truong MJ, Darcissac EC, ''et al.'' |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746-56 |year= 1999 |pmid= 10469138 |doi= }}
*{{cite journal  | vauthors=Efremov R, Truong MJ, Darcissac EC |title=Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function. |journal=Eur. J. Biochem. |volume=263 |issue= 3 |pages= 746–56 |year= 1999 |pmid= 10469138 |doi=10.1046/j.1432-1327.1999.00553.x  |display-authors=etal}}
*{{cite journal  | author=Marrero MB, Venema VJ, Ju H, ''et al.'' |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 Pt 2 |issue=  |pages= 335-40 |year= 1999 |pmid= 10510297 |doi=  }}
*{{cite journal  | vauthors=Marrero MB, Venema VJ, Ju H |title=Endothelial nitric oxide synthase interactions with G-protein-coupled receptors. |journal=Biochem. J. |volume=343 |issue=  2|pages= 335–40 |year= 1999 |pmid= 10510297 |doi=10.1042/0264-6021:3430335 | pmc=1220558  |display-authors=etal}}
*{{cite journal  | author=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658-73 |year= 2000 |pmid= 10653985 |doi=  }}
*{{cite journal  | vauthors=Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L |title=Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 658–73 |year= 2000 |pmid= 10653985 |doi=10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7 }}
*{{cite journal  | author=Golser R, Gorren AC, Leber A, ''et al.'' |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation. |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291-6 |year= 2000 |pmid= 10681501 |doi=  }}
*{{cite journal  | vauthors=Golser R, Gorren AC, Leber A |title=Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5291–6 |year= 2000 |pmid= 10681501 |doi=10.1074/jbc.275.8.5291 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
{{Neuropeptide receptors}}
[[Category:G protein coupled receptors]]
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}
 
[[Category:G protein-coupled receptors]]
{{transmembranereceptor-stub}}

Latest revision as of 06:24, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

Mechanism

The B2 receptor is a G protein-coupled receptor, probably coupled to Gq and Gi. Gq stimulates phospholipase C to increase intracellular free calcium and Gi inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

The B2 receptor forms a complex with angiotensin converting enzyme (ACE), and this is thought to play a role in cross-talk between the renin-angiotensin system (RAS) and the kinin-kallikrein system (KKS). The heptapeptide angiotensin (1-7) also potentiates bradykinin action on B2 receptors.[1]

Kallidin also signals through the B2 receptor. An antagonist for the receptor is Hoe 140 (icatibant).[2]

Function

The 9 amino acid bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation.

Gene

Alternate start codons result in two isoforms of the protein.[3]

See also

References

  1. ↑ Fernandes L, Fortes ZB, Nigro D, Tostes RC, Santos RA, Catelli De Carvalho MH (2001). "Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo". Hypertension. 37 (2 Part 2): 703–9. doi:10.1161/01.hyp.37.2.703. PMID 11230360.
  2. ↑ Wirth K, Hock FJ, Albus U, Linz W, Alpermann HG, Anagnostopoulos H, Henk S, Breipohl G, König W, Knolle J (1991). "Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies". Br. J. Pharmacol. 102: 774–7. doi:10.1111/j.1476-5381.1991.tb12249.x. PMC 1917928. PMID 1364852.
  3. ↑ "Entrez Gene: BDKRB2 bradykinin receptor B2".

External links

Further reading

  • Duchêne J, Schanstra J, Cellier E, et al. (2002). "[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway]". Néphrologie. 23 (1): 39–41. PMID 11908480.
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300.
  • Hess JF, Borkowski JA, Young GS, et al. (1992). "Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor". Biochem. Biophys. Res. Commun. 184 (1): 260–8. doi:10.1016/0006-291X(92)91187-U. PMID 1314587.
  • Eggerickx D, Raspe E, Bertrand D, et al. (1992). "Molecular cloning, functional expression and pharmacological characterization of a human bradykinin B2 receptor gene". Biochem. Biophys. Res. Commun. 187 (3): 1306–13. doi:10.1016/0006-291X(92)90445-Q. PMID 1329734.
  • Kammerer S, Braun A, Arnold N, Roscher AA (1995). "The human bradykinin B2 receptor gene: full length cDNA, genomic organization and identification of the regulatory region". Biochem. Biophys. Res. Commun. 211 (1): 226–33. doi:10.1006/bbrc.1995.1800. PMID 7779089.
  • Braun A, Kammerer S, Böhme E, et al. (1995). "Identification of polymorphic sites of the human bradykinin B2 receptor gene". Biochem. Biophys. Res. Commun. 211 (1): 234–40. doi:10.1006/bbrc.1995.1801. PMID 7779090.
  • Ma JX, Wang DZ, Ward DC, et al. (1995). "Structure and chromosomal localization of the gene (BDKRB2) encoding human bradykinin B2 receptor". Genomics. 23 (2): 362–9. doi:10.1006/geno.1994.1512. PMID 7835885.
  • Powell SJ, Slynn G, Thomas C, et al. (1993). "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14". Genomics. 15 (2): 435–8. doi:10.1006/geno.1993.1084. PMID 7916737.
  • Menke JG, Borkowski JA, Bierilo KK, et al. (1994). "Expression cloning of a human B1 bradykinin receptor". J. Biol. Chem. 269 (34): 21583–6. PMID 8063797.
  • Hess JF, Borkowski JA, Macneil T, et al. (1994). "Differential pharmacology of cloned human and mouse B2 bradykinin receptors". Mol. Pharmacol. 45 (1): 1–8. PMID 8302267.
  • McIntyre P, Phillips E, Skidmore E, et al. (1993). "Cloned murine bradykinin receptor exhibits a mixed B1 and B2 pharmacological selectivity". Mol. Pharmacol. 44 (2): 346–55. PMID 8394991.
  • AbdAlla S, Godovac-Zimmermann J, Braun A, et al. (1996). "Structure of the bradykinin B2 receptors' amino terminus". Biochemistry. 35 (23): 7514–9. doi:10.1021/bi9601060. PMID 8652530.
  • Isami S, Kishikawa H, Araki E, et al. (1996). "Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway". Diabetologia. 39 (4): 412–20. doi:10.1007/BF00400672. PMID 8777990.
  • Dalemar LR, Ivy Jong YJ, Wilhelm B, Baenziger NL (1996). "Protein kinases A and C rapidly modulate expression of human lung fibroblast B2 bradykinin receptor affinity forms". Eur. J. Cell Biol. 69 (3): 236–44. PMID 8900488.
  • Soskic V, Nyakatura E, Roos M, et al. (1999). "Correlations in palmitoylation and multiple phosphorylation of rat bradykinin B2 receptor in Chinese hamster ovary cells". J. Biol. Chem. 274 (13): 8539–45. doi:10.1074/jbc.274.13.8539. PMID 10085087.
  • Cassano G, Susca F, Lippe C, Guanti G (1999). "Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts". Gen. Pharmacol. 32 (2): 239–44. doi:10.1016/S0306-3623(98)00275-4. PMID 10188626.
  • Efremov R, Truong MJ, Darcissac EC, et al. (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function". Eur. J. Biochem. 263 (3): 746–56. doi:10.1046/j.1432-1327.1999.00553.x. PMID 10469138.
  • Marrero MB, Venema VJ, Ju H, et al. (1999). "Endothelial nitric oxide synthase interactions with G-protein-coupled receptors". Biochem. J. 343 (2): 335–40. doi:10.1042/0264-6021:3430335. PMC 1220558. PMID 10510297.
  • Reyes-Cruz G, Vázquez-Prado J, Müller-Esterl W, Vaca L (2000). "Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases". J. Cell. Biochem. 76 (4): 658–73. doi:10.1002/(SICI)1097-4644(20000315)76:4<658::AID-JCB14>3.0.CO;2-7. PMID 10653985.
  • Golser R, Gorren AC, Leber A, et al. (2000). "Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation". J. Biol. Chem. 275 (8): 5291–6. doi:10.1074/jbc.275.8.5291. PMID 10681501.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=Bradykinin_receptor_B2&oldid=1521335"