Bradykinin receptor B1: Difference between revisions

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{{Infobox_gene}}
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'''Bradykinin receptor B1 (B<sub>1</sub>)''' is a [[G-protein coupled receptor]] encoded by the '''BDKRB1''' [[gene]] in humans. Its principal [[ligand]] is [[bradykinin]], a 9 [[amino acid]] peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B<sub>1</sub> receptor is one of two of G protein-coupled receptors that have been found which bind [[bradykinin]] and mediate responses to these pathophysiologic conditions.
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B<sub>1</sub> protein is synthesized ''de novo'' following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: BDKRB1 bradykinin receptor B1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=623| accessdate = }}</ref>
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Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.<ref>{{Cite journal|title = Bradykinin receptors in mouse and rat isolated superior cervical ganglia. | pmid=7670739 | volume=115 | pmc=1908315 | journal=Br J Pharmacol | pages=368–72 | vauthors=Seabrook GR, Bowery BJ, Hill RG | doi=10.1111/j.1476-5381.1995.tb15887.x}}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Bradykinin receptor B1
| HGNCid = 1029
| Symbol = BDKRB1
| AltSymbols =; B1BKR; B1R; BKB1R; BKR1; BRADYB1
| OMIM = 600337
| ECnumber =
| Homologene = 570
| MGIid = 88144
| GeneAtlas_image1 = PBB_GE_BDKRB1_207510_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004947 |text = bradykinin receptor activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 623
    | Hs_Ensembl = ENSG00000100739
    | Hs_RefseqProtein = NP_000701
    | Hs_RefseqmRNA = NM_000710
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 95799760
    | Hs_GenLoc_end = 95800847
    | Hs_Uniprot = P46663
    | Mm_EntrezGene = 12061
    | Mm_Ensembl = ENSMUSG00000041347
    | Mm_RefseqmRNA = NM_007539
    | Mm_RefseqProtein = NP_031565
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 106005141
    | Mm_GenLoc_end = 106006478
    | Mm_Uniprot = Q0VBD7
  }}
}}
'''Bradykinin receptor B1''', also known as '''BDKRB1''', is a human [[gene]].


Bradykinin, a 9 [[amino acid]] peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of [[G protein-coupled receptor]]s have been found which bind [[bradykinin]] and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.<ref name="entrez">{{cite web | title = Entrez Gene: BDKRB1 bradykinin receptor B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=623| accessdate = }}</ref>
==Antagonists==
* [[LF22-0542]]


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2975 | title = Bradykinin Receptors: B<sub>1</sub>  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|BDKRB1}}
* {{UCSC gene info|BDKRB2}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal  | vauthors=Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A |title=A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. |journal=J. Immunol. |volume=179 |issue= 7 |pages= 4849–56 |year= 2007 |pmid= 17878384 |doi= 10.4049/jimmunol.179.7.4849|pmc=3696729 }}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Calixto JB, Medeiros R, Fernandes ES, ''et al.'' |title=Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. |journal=Br. J. Pharmacol. |volume=143 |issue= 7 |pages= 803-18 |year= 2005 |pmid= 15520046 |doi= 10.1038/sj.bjp.0706012 }}
*{{cite journal  | vauthors=Calixto JB, Medeiros R, Fernandes ES |title=Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes |journal=Br. J. Pharmacol. |volume=143 |issue= 7 |pages= 803–18 |year= 2005 |pmid= 15520046 |doi= 10.1038/sj.bjp.0706012 | pmc=1575942 |display-authors=etal}}
*{{cite journal  | author=Menke JG, Borkowski JA, Bierilo KK, ''et al.'' |title=Expression cloning of a human B1 bradykinin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583-6 |year= 1994 |pmid= 8063797 |doi=  }}
*{{cite journal  | vauthors=Menke JG, Borkowski JA, Bierilo KK |title=Expression cloning of a human B1 bradykinin receptor |journal=J. Biol. Chem. |volume=269 |issue= 34 |pages= 21583–6 |year= 1994 |pmid= 8063797 |doi=  |display-authors=etal}}
*{{cite journal  | author=Yang X, Polgar P |title=Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 3 |pages= 718-25 |year= 1996 |pmid= 8651911 |doi= 10.1006/bbrc.1996.0810 }}
*{{cite journal  | vauthors=Yang X, Polgar P |title=Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 3 |pages= 718–25 |year= 1996 |pmid= 8651911 |doi= 10.1006/bbrc.1996.0810 }}
*{{cite journal  | author=Bachvarov DR, Hess JF, Menke JG, ''et al.'' |title=Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). |journal=Genomics |volume=33 |issue= 3 |pages= 374-81 |year= 1996 |pmid= 8660997 |doi= 10.1006/geno.1996.0213 }}
*{{cite journal  | vauthors=Bachvarov DR, Hess JF, Menke JG |title=Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1) |journal=Genomics |volume=33 |issue= 3 |pages= 374–81 |year= 1996 |pmid= 8660997 |doi= 10.1006/geno.1996.0213 |display-authors=etal}}
*{{cite journal  | author=Chai KX, Ni A, Wang D, ''et al.'' |title=Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1. |journal=Genomics |volume=31 |issue= 1 |pages= 51-7 |year= 1996 |pmid= 8808279 |doi= 10.1006/geno.1996.0008 }}
*{{cite journal  | vauthors=Chai KX, Ni A, Wang D |title=Genomic DNA sequence, expression, and chromosomal localization of the human B1 bradykinin receptor gene BDKRB1 |journal=Genomics |volume=31 |issue= 1 |pages= 51–7 |year= 1996 |pmid= 8808279 |doi= 10.1006/geno.1996.0008 |display-authors=etal}}
*{{cite journal  | author=Leeb T, Mathis SA, Leeb-Lundberg LM |title=The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists. |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 311-7 |year= 1997 |pmid= 8995263 |doi=  }}
*{{cite journal  | vauthors=Leeb T, Mathis SA, Leeb-Lundberg LM |title=The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists |journal=J. Biol. Chem. |volume=272 |issue= 1 |pages= 311–7 |year= 1997 |pmid= 8995263 |doi=10.1074/jbc.272.1.311 }}
*{{cite journal  | author=Blaukat A, Herzer K, Schroeder C, ''et al.'' |title=Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation. |journal=Biochemistry |volume=38 |issue= 4 |pages= 1300-9 |year= 1999 |pmid= 9930991 |doi= 10.1021/bi981727r }}
*{{cite journal  | vauthors=Blaukat A, Herzer K, Schroeder C |title=Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation |journal=Biochemistry |volume=38 |issue= 4 |pages= 1300–9 |year= 1999 |pmid= 9930991 |doi= 10.1021/bi981727r |display-authors=etal}}
*{{cite journal  | author=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts. |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239-44 |year= 1999 |pmid= 10188626 |doi=  }}
*{{cite journal  | vauthors=Cassano G, Susca F, Lippe C, Guanti G |title=Two B1 and B2 bradykinin receptor antagonists fail to inhibit the Ca2+ response elicited by bradykinin in human skin fibroblasts |journal=Gen. Pharmacol. |volume=32 |issue= 2 |pages= 239–44 |year= 1999 |pmid= 10188626 |doi=10.1016/S0306-3623(98)00275-4 }}
*{{cite journal  | author=Zhou X, Prado GN, Chai M, ''et al.'' |title=Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region. |journal=Mol. Cell Biol. Res. Commun. |volume=1 |issue= 1 |pages= 29-35 |year= 2000 |pmid= 10329474 |doi= 10.1006/mcbr.1999.0105 }}
*{{cite journal  | vauthors=Zhou X, Prado GN, Chai M |title=Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region |journal=Mol. Cell Biol. Res. Commun. |volume=1 |issue= 1 |pages= 29–35 |year= 2000 |pmid= 10329474 |doi= 10.1006/mcbr.1999.0105 |display-authors=etal}}
*{{cite journal  | author=Jones C, Phillips E, Davis C, ''et al.'' |title=Molecular characterisation of cloned bradykinin B1 receptors from rat and human. |journal=Eur. J. Pharmacol. |volume=374 |issue= 3 |pages= 423-33 |year= 1999 |pmid= 10422787 |doi=  }}
*{{cite journal  | vauthors=Jones C, Phillips E, Davis C |title=Molecular characterisation of cloned bradykinin B1 receptors from rat and human |journal=Eur. J. Pharmacol. |volume=374 |issue= 3 |pages= 423–33 |year= 1999 |pmid= 10422787 |doi=10.1016/S0014-2999(99)00315-5 |display-authors=etal}}
*{{cite journal  | author=Sjuve R, Boels PJ, Uvelius B, Arner A |title=Up-regulation of bradykinin response in rat and human bladder smooth muscle. |journal=J. Urol. |volume=164 |issue= 5 |pages= 1757-63 |year= 2000 |pmid= 11025765 |doi=  }}
*{{cite journal  | vauthors=Sjuve R, Boels PJ, Uvelius B, Arner A |title=Up-regulation of bradykinin response in rat and human bladder smooth muscle |journal=J. Urol. |volume=164 |issue= 5 |pages= 1757–63 |year= 2000 |pmid= 11025765 |doi=10.1016/S0022-5347(05)67102-9 }}
*{{cite journal  | author=Sawant S, Snyman C, Bhoola K |title=Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms. |journal=Int. Immunopharmacol. |volume=1 |issue= 12 |pages= 2063-80 |year= 2002 |pmid= 11710536 |doi=  }}
*{{cite journal  | vauthors=Sawant S, Snyman C, Bhoola K |title=Comparison of tissue kallikrein and kinin receptor expression in gastric ulcers and neoplasms |journal=Int. Immunopharmacol. |volume=1 |issue= 12 |pages= 2063–80 |year= 2002 |pmid= 11710536 |doi=10.1016/S1567-5769(01)00118-7 }}
*{{cite journal  | author=Ignjatovic T, Tan F, Brovkovych V, ''et al.'' |title=Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16847-52 |year= 2002 |pmid= 11880373 |doi= 10.1074/jbc.M200355200 }}
*{{cite journal  | vauthors=Ignjatovic T, Tan F, Brovkovych V |title=Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16847–52 |year= 2002 |pmid= 11880373 |doi= 10.1074/jbc.M200355200 |display-authors=etal}}
*{{cite journal  | author=Newton R, Eddleston J, Haddad el-B, ''et al.'' |title=Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone. |journal=Eur. J. Pharmacol. |volume=441 |issue= 3 |pages= 193-202 |year= 2002 |pmid= 12063092 |doi=  }}
*{{cite journal  | vauthors=Newton R, Eddleston J, ((Haddad el-B)) |title=Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone |journal=Eur. J. Pharmacol. |volume=441 |issue= 3 |pages= 193–202 |year= 2002 |pmid= 12063092 |doi=10.1016/S0014-2999(01)01624-7 |display-authors=etal}}
*{{cite journal  | author=Kang DS, Leeb-Lundberg LM |title=Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity. |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 281-8 |year= 2002 |pmid= 12130679 |doi= }}
*{{cite journal  | vauthors=Kang DS, Leeb-Lundberg LM |title=Negative and positive regulatory epitopes in the C-terminal domains of the human B1 and B2 bradykinin receptor subtypes determine receptor coupling efficacy to G(q/11)-mediated [correction of G(9/11)-mediated] phospholipase Cbeta activity |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 281–8 |year= 2002 |pmid= 12130679 |doi=10.1124/mol.62.2.281  }}
*{{cite journal  | author=Christiansen SC, Eddleston J, Woessner KM, ''et al.'' |title=Up-regulation of functional kinin B1 receptors in allergic airway inflammation. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 2054-60 |year= 2002 |pmid= 12165532 |doi=  }}
*{{cite journal  | vauthors=Christiansen SC, Eddleston J, Woessner KM |title=Up-regulation of functional kinin B1 receptors in allergic airway inflammation |journal=J. Immunol. |volume=169 |issue= 4 |pages= 2054–60 |year= 2002 |pmid= 12165532 |doi=  10.4049/jimmunol.169.4.2054|display-authors=etal}}
*{{cite journal  | author=Lamb ME, Zhang C, Shea T, ''et al.'' |title=Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells. |journal=Biochemistry |volume=41 |issue= 48 |pages= 14340-7 |year= 2003 |pmid= 12450400 |doi=  }}
*{{cite journal  | vauthors=Lamb ME, Zhang C, Shea T |title=Human B1 and B2 bradykinin receptors and their agonists target caveolae-related lipid rafts to different degrees in HEK293 cells |journal=Biochemistry |volume=41 |issue= 48 |pages= 14340–7 |year= 2003 |pmid= 12450400 |doi=10.1021/bi020231d |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM |title=Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22102-7 |year= 2004 |pmid= 15033977 |doi= 10.1074/jbc.M402572200 }}
*{{cite journal  | vauthors=Kang DS, Ryberg K, Mörgelin M, Leeb-Lundberg LM |title=Spontaneous formation of a proteolytic B1 and B2 bradykinin receptor complex with enhanced signaling capacity |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22102–7 |year= 2004 |pmid= 15033977 |doi= 10.1074/jbc.M402572200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
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{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
{{Neuropeptide receptors}}
[[Category:G protein coupled receptors]]
 
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[[Category:G protein-coupled receptors]]
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Latest revision as of 06:22, 10 January 2019

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.[1]

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.[2]

Antagonists

See also

References

  1. ↑ "Entrez Gene: BDKRB1 bradykinin receptor B1".
  2. ↑ Seabrook GR, Bowery BJ, Hill RG. "Bradykinin receptors in mouse and rat isolated superior cervical ganglia". Br J Pharmacol. 115: 368–72. doi:10.1111/j.1476-5381.1995.tb15887.x. PMC 1908315. PMID 7670739.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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