Azaperone: Difference between revisions

Jump to navigation Jump to search
m (Protected "Azaperone": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)))
 
No edit summary
Line 1: Line 1:
{{drugbox |
{{one source|date=December 2014}}
{{Drugbox
| Verifiedfields = changed
| verifiedrevid = 458788100
| IUPAC_name = 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
| IUPAC_name = 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one
| image = Azaperone structure.svg
| image = Azaperone structure.png
| width = 180
| width = 180
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|azaperone}}
| pregnancy_AU = 
| pregnancy_US = 
| pregnancy_category = 
| legal_AU = 
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status = 
| routes_of_administration = intramuscular injection
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = hepatic
| elimination_half-life = 4 hours
<!--Identifiers-->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 1649-18-9
| CAS_number = 1649-18-9
| ATC_prefix =  
| ATCvet = yes
| ATC_suffix =  
| ATC_prefix = N01
| ATC_suffix = AX91
| ATC_supplemental =  {{ATCvet|N05|AD90}}
| PubChem = 15443
| PubChem = 15443
| C=19 | H=22 | F=1 | N=3 | O=1
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 14695
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 19BV78AK7W
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02620
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 340211
 
<!--Chemical data-->
| C=19 | H=22 | F=1 | N=3 | O=1  
| molecular_weight = 327.396 g/mol
| molecular_weight = 327.396 g/mol
| smiles = C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=CC=CC=N3
| smiles = Fc1ccc(cc1)C(=O)CCCN3CCN(c2ncccc2)CC3
| InChI = 1/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
| InChIKey = XTKDAFGWCDAMPY-UHFFFAOYAD
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = XTKDAFGWCDAMPY-UHFFFAOYSA-N
| melting_point = 90
| melting_point = 90
| melting_high = 95
| melting_high = 95
| bioavailability =
| protein_bound =
| metabolism = hepatic
| elimination_half-life = 4 hours
| excretion =
| pregnancy_AU = 
| pregnancy_US =
| pregnancy_category = 
| legal_AU =
| legal_CA =
| legal_UK =
| legal_US =
| legal_status =
| routes_of_administration = intramuscular injection
}}
}}
__NOTOC__
{{SI}}
{{CMG}}


'''Azaperone''' ('''Stresnil''', '''Fluoperidol''') is a [[butyrophenone]] [[neuroleptic]] drug with [[sedative]] and [[anti-emetic]] effects, which is used mainly as a [[tranquilizer]] in [[veterinary]] medicine. It is used mainly in pigs and elephants. [http://www.elephantcare.org/Drugs/azaperon.htm] More rarely it may be used in humans as an [[antipsychotic]] drug, but this is uncommon. Use in horses is avoided as adverse reactions may occur.
==Overview==
'''Azaperone''' ('''Stresnil''', '''Fluoperidol''') is a [[pyridinylpiperazine]] and [[butyrophenone]] [[neuroleptic]] [[drug]] with [[sedative]] and [[antiemetic]] effects, which is used mainly as a [[tranquilizer]] in [[veterinary]] medicine. It is used mainly in pigs and elephants. <ref>[http://www.elephantcare.org/Drugs/azaperon.htm The Elephant Formulary]</ref> More rarely it may be used in humans as an [[antipsychotic]] drug, but this is uncommon. Use in horses is avoided as adverse reactions may occur.


Azaperone acts primarily as a [[dopamine]] [[antagonist (pharmacology)|antagonist]] but also has some [[histamine|antihistaminic]] and [[choline|anticholinergic]] properties as seen with similar drugs such as [[haloperidol]]. Azaperone may cause [[hypotension]] and while it has minimal effects on respiration in pigs, high doses in humans can cause [[respiratory depression]] which may be why it is rarely used in humans.  
Azaperone acts primarily as a [[dopamine]] [[antagonist (pharmacology)|antagonist]] but also has some [[histamine|antihistaminic]] and [[choline|anticholinergic]] properties as seen with similar drugs such as [[haloperidol]]. Azaperone may cause [[hypotension]] and while it has minimal effects on respiration in pigs, high doses in humans can cause [[respiratory depression]] which may be why it is rarely used in humans.  


The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for [[anesthesia]] in combination with other drugs such as [[xylazine]], [[tiletamine]] and [[zolazepam]]. Azaperone is also used in combination with strong narcotics such as [[etorphine]] or [[carfentanil]] for tranquilizing large animals such as elephants.
The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for [[anesthesia]] in combination with other drugs such as [[xylazine]], [[tiletamine]] and [[zolazepam]]. Azaperone is also used in combination with strong narcotics such as [[etorphine]] or [[carfentanil]] for tranquilizing large animals such as elephants.
== References ==
{{Reflist|2}}


{{Antipsychotics}}
{{Antipsychotics}}
{{Cholinergics}}
{{Dopaminergics}}
{{Histaminergics}}
{{Piperazines}}


[[Category:Typical antipsychotics]]
[[Category:Piperazines]]
{{WikiDoc Help Menu}}
[[Category:Pyridines]]
[[Category:Butyrophenone antipsychotics]]
[[Category:Drug]]

Revision as of 17:32, 13 April 2015

Azaperone
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
intramuscular injection
ATCvet code
Pharmacokinetic data
Metabolismhepatic
Elimination half-life4 hours
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H22FN3O
Molar mass327.396 g/mol
3D model (JSmol)
Melting point90 to 95 °C (Expression error: Unrecognized word "to". °F)
 ☒N☑Y (what is this?)  (verify)


WikiDoc Resources for Azaperone

Articles

Most recent articles on Azaperone

Most cited articles on Azaperone

Review articles on Azaperone

Articles on Azaperone in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Azaperone

Images of Azaperone

Photos of Azaperone

Podcasts & MP3s on Azaperone

Videos on Azaperone

Evidence Based Medicine

Cochrane Collaboration on Azaperone

Bandolier on Azaperone

TRIP on Azaperone

Clinical Trials

Ongoing Trials on Azaperone at Clinical Trials.gov

Trial results on Azaperone

Clinical Trials on Azaperone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Azaperone

NICE Guidance on Azaperone

NHS PRODIGY Guidance

FDA on Azaperone

CDC on Azaperone

Books

Books on Azaperone

News

Azaperone in the news

Be alerted to news on Azaperone

News trends on Azaperone

Commentary

Blogs on Azaperone

Definitions

Definitions of Azaperone

Patient Resources / Community

Patient resources on Azaperone

Discussion groups on Azaperone

Patient Handouts on Azaperone

Directions to Hospitals Treating Azaperone

Risk calculators and risk factors for Azaperone

Healthcare Provider Resources

Symptoms of Azaperone

Causes & Risk Factors for Azaperone

Diagnostic studies for Azaperone

Treatment of Azaperone

Continuing Medical Education (CME)

CME Programs on Azaperone

International

Azaperone en Espanol

Azaperone en Francais

Business

Azaperone in the Marketplace

Patents on Azaperone

Experimental / Informatics

List of terms related to Azaperone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Azaperone (Stresnil, Fluoperidol) is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is used mainly in pigs and elephants. [1] More rarely it may be used in humans as an antipsychotic drug, but this is uncommon. Use in horses is avoided as adverse reactions may occur.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression which may be why it is rarely used in humans.

The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for anesthesia in combination with other drugs such as xylazine, tiletamine and zolazepam. Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants.

References

Template:Piperazines