5-HT2B receptor

5-hydroxytryptamine (serotonin) receptor 2B
Identifiers
Symbols	HTR2B ; 5-HT(2B); 5-HT2B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55492
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

5-hydroxytryptamine (serotonin) receptor 2B, also known as HTR2B, is a 5-HT₂ receptor, but also denotes the human gene encoding it.

Function	Agonists	Antagonists
CNS: presynaptic inhibition, behavioural effects vascular: pulmonary vasoconstriction	ergotamine sumatriptan	methiothepin yohimbine metergoline

See also

• 5-HT receptor

Further reading

• Raymond JR, Mukhin YV, Gelasco A; et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction". Pharmacol. Ther. 92 (2–3): 179–212. PMID 11916537.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonhaus DW, Bach C, DeSouza A; et al. (1995). "The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors". Br. J. Pharmacol. 115 (4): 622–8. PMID 7582481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Choi DS, Birraux G, Launay JM, Maroteaux L (1994). "The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors". FEBS Lett. 352 (3): 393–9. PMID 7926008.CS1 maint: Multiple names: authors list (link)
• Kursar JD, Nelson DL, Wainscott DB, Baez M (1994). "Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor". Mol. Pharmacol. 46 (2): 227–34. PMID 8078486.CS1 maint: Multiple names: authors list (link)
• Schmuck K, Ullmer C, Engels P, Lübbert H (1994). "Cloning and functional characterization of the human 5-HT2B serotonin receptor". FEBS Lett. 342 (1): 85–90. PMID 8143856.CS1 maint: Multiple names: authors list (link)
• Launay JM, Birraux G, Bondoux D; et al. (1996). "Ras involvement in signal transduction by the serotonin 5-HT2B receptor". J. Biol. Chem. 271 (6): 3141–7. PMID 8621713.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Le Coniat M, Choi DS, Maroteaux L; et al. (1996). "The 5-HT2B receptor gene maps to 2q36.3-2q37.1". Genomics. 32 (1): 172–3. doi:10.1006/geno.1996.0101. PMID 8786115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim SJ, Veenstra-VanderWeele J, Hanna GL; et al. (2000). "Mutation screening of human 5-HT(2B)receptor gene in early-onset obsessive-compulsive disorder". Mol. Cell. Probes. 14 (1): 47–52. doi:10.1006/mcpr.1999.0281. PMID 10722792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manivet P, Mouillet-Richard S, Callebert J; et al. (2000). "PDZ-dependent activation of nitric-oxide synthases by the serotonin 2B receptor". J. Biol. Chem. 275 (13): 9324–31. PMID 10734074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Becamel C, Figge A, Poliak S; et al. (2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Manivet P, Schneider B, Smith JC; et al. (2002). "The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis". J. Biol. Chem. 277 (19): 17170–8. doi:10.1074/jbc.M200195200. PMID 11859080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borman RA, Tilford NS, Harmer DW; et al. (2002). "5-HT(2B) receptors play a key role in mediating the excitatory effects of 5-HT in human colon in vitro". Br. J. Pharmacol. 135 (5): 1144–51. doi:10.1038/sj.bjp.0704571. PMID 11877320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Slominski A, Pisarchik A, Zbytek B; et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53. doi:10.1002/jcp.10287. PMID 12767050.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lin Z, Walther D, Yu XY; et al. (2005). "The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse". Pharmacogenetics. 14 (12): 805–11. PMID 15608559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.