ADCYAP1R1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
{{Infobox_gene}}
'''Pituitary adenylate cyclase-activating polypeptide type I receptor''' also known as '''PAC<sub>1</sub>''', is a [[protein]] that in humans is encoded by the ''ADCYAP1R1'' [[gene]].<ref name="entrez"/>  This receptor binds [[pituitary adenylate cyclase activating peptide]].<ref name="pmid7902709">{{cite journal | vauthors = Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M | title = Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 3 | pages = 1511–21 | date = Nov 1993 | pmid = 7902709 | doi = 10.1006/bbrc.1993.2423 }}</ref><ref name="pmid10835102">{{cite journal | vauthors = Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H | title = Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions | journal = Pharmacological Reviews | volume = 52 | issue = 2 | pages = 269–324 | date = Jun 2000 | pmid = 10835102 | doi =  | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/52/2/269 }}</ref>


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
PAC<sub>1</sub> is a membrane-associated protein and shares significant homology with members of the [[G-protein coupled receptor|G-protein coupled]] class B [[glucagon receptor|glucagon]]/[[secretin receptor]] family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. [[Alternative splicing]] of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117| accessdate = }}</ref> PAC<sub>1</sub> is expressed in the [[adrenal medulla]], [[pancreas|pancreatic acini]], [[uterus]], [[myenteric plexus]] and [[brain]].<ref name="pmid11193811">{{cite journal | vauthors = Reubi JC | title = In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications | journal = Annals of the New York Academy of Sciences | volume = 921 | issue =  | pages = 1–25 | year = 2000 | pmid = 11193811 | doi = 10.1111/j.1749-6632.2000.tb06946.x }}</ref><ref name="pmid10850463">{{cite journal | vauthors = Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA | title = Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin | journal = Cancer Research | volume = 60 | issue = 11 | pages = 3105–12 | date = Jun 2000 | pmid = 10850463 | doi =  }}</ref><ref name="pmid9543159">{{cite journal | vauthors = Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N | title = Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 83 | issue = 4 | pages = 1299–305 | date = Apr 1998 | pmid = 9543159 | doi = 10.1210/jc.83.4.1299 }}</ref> It is also expressed in the [[Trigeminal ganglion|trigeminal]], [[Otic ganglion|otic]] and [[Superior cervical ganglion|superior cervical ganglia]] (prejunctional) and cerebral arteries (postjunctional).<ref name="Knutsson-2002">{{cite journal | vauthors = Knutsson M, Edvinsson L | title = Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia | journal = NeuroReport | volume = 13 | issue = 4 | pages = 507–9 | date = Mar 2002 | pmid = 11930171 | doi = 10.1097/00001756-200203250-00030 }}</ref>
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
| HGNCid = 242
| Symbol = ADCYAP1R1
| AltSymbols =; PACAPR; PACAPRI
| OMIM = 102981
| ECnumber = 
| Homologene = 870
| MGIid = 108449
| GeneAtlas_image1 = PBB_GE_ADCYAP1R1_207151_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004930 |text = G-protein coupled receptor activity}} {{GNF_GO|id=GO:0004999 |text = vasoactive intestinal polypeptide receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 117
    | Hs_Ensembl = ENSG00000078549
    | Hs_RefseqProtein = NP_001109
    | Hs_RefseqmRNA = NM_001118
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 31058667
    | Hs_GenLoc_end = 31112836
    | Hs_Uniprot = P41586
    | Mm_EntrezGene = 11517
    | Mm_Ensembl = ENSMUSG00000029778
    | Mm_RefseqmRNA = NM_001025372
    | Mm_RefseqProtein = NP_001020543
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 55381558
    | Mm_GenLoc_end = 55431033
    | Mm_Uniprot = Q8BLT3
  }}
}}
'''Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I''', also known as '''ADCYAP1R1''' or '''pituitary adenylate cyclase-activating polypeptide receptor 1''' ('''PACAPR1'''), is a human [[gene]].  This receptor binds [[pituitary adenylate cyclase activating peptide]].<ref name="pmid7902709">{{cite journal | author = Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M | title = Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor | journal = Biochem. Biophys. Res. Commun. | volume = 196 | issue = 3 | pages = 1511–21 | year = 1993 | pmid = 7902709 | doi = 10.1006/bbrc.1993.2423 | issn = }}</ref><ref name="pmid10835102">{{cite journal | author = Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H | title = Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions | journal = Pharmacol. Rev. | volume = 52 | issue = 2 | pages = 269–324 | year = 2000 | pmid = 10835102 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/52/2/269 }}</ref>


This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the [[G-protein coupled receptor|G-protein coupled]] class B [[glucagon receptor| glucagon]]/[[secretin receptor]] family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=117| accessdate = }}</ref>
== Further reading ==
 
 
==References==
{{reflist|2}}
 
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI | title = Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7 | journal = Genomics | volume = 23 | issue = 3 | pages = 697–9 | date = Oct 1994 | pmid = 7851900 | doi = 10.1006/geno.1994.1560 }}
| citations =
* {{cite journal | vauthors = Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M | title = Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor | journal = Biochemical and Biophysical Research Communications | volume = 196 | issue = 3 | pages = 1511–21 | date = Nov 1993 | pmid = 7902709 | doi = 10.1006/bbrc.1993.2423 }}
*{{cite journal | author=Stoffel M, Espinosa R, Trabb JB, ''et al.'' |title=Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7. |journal=Genomics |volume=23 |issue= 3 |pages= 697-9 |year= 1995 |pmid= 7851900 |doi= 10.1006/geno.1994.1560 }}
* {{cite journal | vauthors = Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M | title = Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide | journal = The Journal of Biological Chemistry | volume = 268 | issue = 35 | pages = 26650–7 | date = Dec 1993 | pmid = 8253796 | doi =  }}
*{{cite journal | author=Ogi K, Miyamoto Y, Masuda Y, ''et al.'' |title=Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. |journal=Biochem. Biophys. Res. Commun. |volume=196 |issue= 3 |pages= 1511-21 |year= 1994 |pmid= 7902709 |doi= 10.1006/bbrc.1993.2423 }}
* {{cite journal | vauthors = Pisegna JR, Wank SA | title = Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C | journal = The Journal of Biological Chemistry | volume = 271 | issue = 29 | pages = 17267–74 | date = Jul 1996 | pmid = 8663363 | doi = 10.1074/jbc.271.29.17267 }}
*{{cite journal | author=Ohtaki T, Masuda Y, Ishibashi Y, ''et al.'' |title=Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26650-7 |year= 1994 |pmid= 8253796 |doi=  }}
* {{cite journal | vauthors = Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L | title = Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22146–51 | date = Sep 1996 | pmid = 8703026 | doi = 10.1074/jbc.271.36.22146 }}
*{{cite journal | author=Pisegna JR, Wank SA |title=Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C. |journal=J. Biol. Chem. |volume=271 |issue= 29 |pages= 17267-74 |year= 1996 |pmid= 8663363 |doi= }}
* {{cite journal | vauthors = Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC | title = Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate | journal = Endocrinology | volume = 137 | issue = 7 | pages = 2815–22 | date = Jul 1996 | pmid = 8770902 | doi = 10.1210/en.137.7.2815 }}
*{{cite journal | author=Pantaloni C, Brabet P, Bilanges B, ''et al.'' |title=Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22146-51 |year= 1996 |pmid= 8703026 |doi= }}
* {{cite journal | vauthors = Wei Y, Mojsov S | title = Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology | journal = Journal of Neuroendocrinology | volume = 8 | issue = 11 | pages = 811–7 | date = Nov 1996 | pmid = 8933357 | doi = 10.1046/j.1365-2826.1996.05191.x }}
*{{cite journal | author=Solano RM, Carmena MJ, Carrero I, ''et al.'' |title=Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate. |journal=Endocrinology |volume=137 |issue= 7 |pages= 2815-22 |year= 1996 |pmid= 8770902 |doi= }}
* {{cite journal | vauthors = Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S | title = Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization | journal = Genomics | volume = 38 | issue = 1 | pages = 100–2 | date = Nov 1996 | pmid = 8954788 | doi = 10.1006/geno.1996.0600 }}
*{{cite journal | author=Wei Y, Mojsov S |title=Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology. |journal=J. Neuroendocrinol. |volume=8 |issue= 11 |pages= 811-7 |year= 1997 |pmid= 8933357 |doi= }}
* {{cite journal | vauthors = Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N | title = Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 83 | issue = 4 | pages = 1299–305 | date = Apr 1998 | pmid = 9543159 | doi = 10.1210/jc.83.4.1299 }}
*{{cite journal | author=Brabet P, Diriong S, Journot L, ''et al.'' |title=Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization. |journal=Genomics |volume=38 |issue= 1 |pages= 100-2 |year= 1997 |pmid= 8954788 |doi= 10.1006/geno.1996.0600 }}
* {{cite journal | vauthors = Steinhoff M, McGregor GP, Radleff-Schlimme A, Steinhoff A, Jarry H, Schmidt WE | title = Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis | journal = Regulatory Peptides | volume = 80 | issue = 1-2 | pages = 49–55 | date = Mar 1999 | pmid = 10235634 | doi = 10.1016/S0167-0115(99)00010-5 }}
*{{cite journal | author=Yon L, Breault L, Contesse V, ''et al.'' |title=Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 4 |pages= 1299-305 |year= 1998 |pmid= 9543159 |doi= }}
* {{cite journal | vauthors = Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR | title = PACAP type I receptor activation regulates ECL cells and gastric acid secretion | journal = The Journal of Clinical Investigation | volume = 104 | issue = 10 | pages = 1383–91 | date = Nov 1999 | pmid = 10562300 | pmc = 409843 | doi = 10.1172/JCI7537 }}
*{{cite journal | author=Steinhoff M, McGregor GP, Radleff-Schlimme A, ''et al.'' |title=Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis. |journal=Regul. Pept. |volume=80 |issue= 1-2 |pages= 49-55 |year= 1999 |pmid= 10235634 |doi= }}
* {{cite journal | vauthors = Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL | title = N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants | journal = Journal of Neuroendocrinology | volume = 11 | issue = 12 | pages = 941–9 | date = Dec 1999 | pmid = 10583729 | doi = 10.1046/j.1365-2826.1999.00411.x }}
*{{cite journal | author=Zeng N, Athmann C, Kang T, ''et al.'' |title=PACAP type I receptor activation regulates ECL cells and gastric acid secretion. |journal=J. Clin. Invest. |volume=104 |issue= 10 |pages= 1383-91 |year= 1999 |pmid= 10562300 |doi= }}
* {{cite journal | vauthors = Scaldaferri ML, Modesti A, Palumbo C, Ulisse S, Fabbri A, Piccione E, Frajese G, Moretti C | title = Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta | journal = Endocrinology | volume = 141 | issue = 3 | pages = 1158–67 | date = Mar 2000 | pmid = 10698193 | doi = 10.1210/en.141.3.1158 }}
*{{cite journal | author=Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL |title=N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. |journal=J. Neuroendocrinol. |volume=11 |issue= 12 |pages= 941-9 |year= 2000 |pmid= 10583729 |doi= }}
* {{cite journal | vauthors = Busto R, Prieto JC, Bodega G, Zapatero J, Carrero I | title = Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung | journal = Peptides | volume = 21 | issue = 2 | pages = 265–9 | date = Feb 2000 | pmid = 10764955 | doi = 10.1016/S0196-9781(99)00202-8 }}
*{{cite journal | author=Scaldaferri ML, Modesti A, Palumbo C, ''et al.'' |title=Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. |journal=Endocrinology |volume=141 |issue= 3 |pages= 1158-67 |year= 2000 |pmid= 10698193 |doi= }}
* {{cite journal | vauthors = Knutsson M, Edvinsson L | title = Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia | journal = NeuroReport | volume = 13 | issue = 4 | pages = 507–9 | date = Mar 2002 | pmid = 11930171 | doi = 10.1097/00001756-200203250-00030 }}
*{{cite journal | author=Busto R, Prieto JC, Bodega G, ''et al.'' |title=Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung. |journal=Peptides |volume=21 |issue= 2 |pages= 265-9 |year= 2000 |pmid= 10764955 |doi= }}
* {{cite journal | vauthors = Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR | title = Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons | journal = Regulatory Peptides | volume = 105 | issue = 3 | pages = 145–54 | date = May 2002 | pmid = 11959368 | doi = 10.1016/S0167-0115(02)00003-4 }}
*{{cite journal | author=Knutsson M, Edvinsson L |title=Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia. |journal=Neuroreport |volume=13 |issue= 4 |pages= 507-9 |year= 2002 |pmid= 11930171 |doi= }}
* {{cite journal | vauthors = Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P | title = PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells | journal = Regulatory Peptides | volume = 109 | issue = 1-3 | pages = 115–25 | date = Nov 2002 | pmid = 12409223 | doi = 10.1016/S0167-0115(02)00194-5 }}
*{{cite journal | author=Miampamba M, Germano PM, Arli S, ''et al.'' |title=Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons. |journal=Regul. Pept. |volume=105 |issue= 3 |pages= 145-54 |year= 2002 |pmid= 11959368 |doi= }}
* {{cite journal | vauthors = Ronaldson E, Robertson DN, Johnson MS, Holland PJ, Mitchell R, Lutz EM | title = Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF | journal = Regulatory Peptides | volume = 109 | issue = 1-3 | pages = 193–8 | date = Nov 2002 | pmid = 12409233 | doi = 10.1016/S0167-0115(02)00204-5 }}
*{{cite journal | author=Le SV, Yamaguchi DJ, McArdle CA, ''et al.'' |title=PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells. |journal=Regul. Pept. |volume=109 |issue= 1-3 |pages= 115-25 |year= 2003 |pmid= 12409223 |doi= }}
* {{cite journal | vauthors = Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, Nakai T | title = Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis | journal = Regulatory Peptides | volume = 110 | issue = 3 | pages = 213–7 | date = Feb 2003 | pmid = 12573802 | doi = 10.1016/S0167-0115(02)00209-4 }}
*{{cite journal | author=Ronaldson E, Robertson DN, Johnson MS, ''et al.'' |title=Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF. |journal=Regul. Pept. |volume=109 |issue= 1-3 |pages= 193-8 |year= 2003 |pmid= 12409233 |doi= }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Isobe K, Tatsuno I, Yashiro T, ''et al.'' |title=Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis. |journal=Regul. Pept. |volume=110 |issue= 3 |pages= 213-7 |year= 2003 |pmid= 12573802 |doi=  }}
}}
{{refend}}
{{refend}}
== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2447 | title = VIP and PACAP Receptors: PAC<sub>1</sub> | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
* {{UCSC gene info|ADCYAP1R1}}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
 
{{Growth factor receptor modulators}}
{{WH}}
{{WS}}

Latest revision as of 00:33, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a protein that in humans is encoded by the ADCYAP1R1 gene.[1] This receptor binds pituitary adenylate cyclase activating peptide.[2][3]

Function

PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined.[1] PAC1 is expressed in the adrenal medulla, pancreatic acini, uterus, myenteric plexus and brain.[4][5][6] It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).[7]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I".
  2. ↑ Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  3. ↑ Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H (Jun 2000). "Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions". Pharmacological Reviews. 52 (2): 269–324. PMID 10835102.
  4. ↑ Reubi JC (2000). "In vitro evaluation of VIP/PACAP receptors in healthy and diseased human tissues. Clinical implications". Annals of the New York Academy of Sciences. 921: 1–25. doi:10.1111/j.1749-6632.2000.tb06946.x. PMID 11193811.
  5. ↑ Reubi JC, Läderach U, Waser B, Gebbers JO, Robberecht P, Laissue JA (Jun 2000). "Vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptor subtypes in human tumors and their tissues of origin". Cancer Research. 60 (11): 3105–12. PMID 10850463.
  6. ↑ Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.
  7. ↑ Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.

Further reading

  • Stoffel M, Espinosa R, Trabb JB, Le Beau MM, Bell GI (Oct 1994). "Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7". Genomics. 23 (3): 697–9. doi:10.1006/geno.1994.1560. PMID 7851900.
  • Ogi K, Miyamoto Y, Masuda Y, Habata Y, Hosoya M, Ohtaki T, Masuo Y, Onda H, Fujino M (Nov 1993). "Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor". Biochemical and Biophysical Research Communications. 196 (3): 1511–21. doi:10.1006/bbrc.1993.2423. PMID 7902709.
  • Ohtaki T, Masuda Y, Ishibashi Y, Kitada C, Arimura A, Fujino M (Dec 1993). "Purification and characterization of the receptor for pituitary adenylate cyclase-activating polypeptide". The Journal of Biological Chemistry. 268 (35): 26650–7. PMID 8253796.
  • Pisegna JR, Wank SA (Jul 1996). "Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C". The Journal of Biological Chemistry. 271 (29): 17267–74. doi:10.1074/jbc.271.29.17267. PMID 8663363.
  • Pantaloni C, Brabet P, Bilanges B, Dumuis A, Houssami S, Spengler D, Bockaert J, Journot L (Sep 1996). "Alternative splicing in the N-terminal extracellular domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor modulates receptor selectivity and relative potencies of PACAP-27 and PACAP-38 in phospholipase C activation". The Journal of Biological Chemistry. 271 (36): 22146–51. doi:10.1074/jbc.271.36.22146. PMID 8703026.
  • Solano RM, Carmena MJ, Carrero I, Cavallaro S, Roman F, Hueso C, Travali S, Lopez-Fraile N, Guijarro LG, Prieto JC (Jul 1996). "Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate". Endocrinology. 137 (7): 2815–22. doi:10.1210/en.137.7.2815. PMID 8770902.
  • Wei Y, Mojsov S (Nov 1996). "Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology". Journal of Neuroendocrinology. 8 (11): 811–7. doi:10.1046/j.1365-2826.1996.05191.x. PMID 8933357.
  • Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S (Nov 1996). "Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization". Genomics. 38 (1): 100–2. doi:10.1006/geno.1996.0600. PMID 8954788.
  • Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, Lehoux JG, Vaudry H, Gallo-Payet N (Apr 1998). "Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation". The Journal of Clinical Endocrinology and Metabolism. 83 (4): 1299–305. doi:10.1210/jc.83.4.1299. PMID 9543159.
  • Steinhoff M, McGregor GP, Radleff-Schlimme A, Steinhoff A, Jarry H, Schmidt WE (Mar 1999). "Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis". Regulatory Peptides. 80 (1–2): 49–55. doi:10.1016/S0167-0115(99)00010-5. PMID 10235634.
  • Zeng N, Athmann C, Kang T, Lyu RM, Walsh JH, Ohning GV, Sachs G, Pisegna JR (Nov 1999). "PACAP type I receptor activation regulates ECL cells and gastric acid secretion". The Journal of Clinical Investigation. 104 (10): 1383–91. doi:10.1172/JCI7537. PMC 409843. PMID 10562300.
  • Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL (Dec 1999). "N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants". Journal of Neuroendocrinology. 11 (12): 941–9. doi:10.1046/j.1365-2826.1999.00411.x. PMID 10583729.
  • Scaldaferri ML, Modesti A, Palumbo C, Ulisse S, Fabbri A, Piccione E, Frajese G, Moretti C (Mar 2000). "Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta". Endocrinology. 141 (3): 1158–67. doi:10.1210/en.141.3.1158. PMID 10698193.
  • Busto R, Prieto JC, Bodega G, Zapatero J, Carrero I (Feb 2000). "Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung". Peptides. 21 (2): 265–9. doi:10.1016/S0196-9781(99)00202-8. PMID 10764955.
  • Knutsson M, Edvinsson L (Mar 2002). "Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia". NeuroReport. 13 (4): 507–9. doi:10.1097/00001756-200203250-00030. PMID 11930171.
  • Miampamba M, Germano PM, Arli S, Wong HH, Scott D, Taché Y, Pisegna JR (May 2002). "Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons". Regulatory Peptides. 105 (3): 145–54. doi:10.1016/S0167-0115(02)00003-4. PMID 11959368.
  • Le SV, Yamaguchi DJ, McArdle CA, Tachiki K, Pisegna JR, Germano P (Nov 2002). "PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells". Regulatory Peptides. 109 (1–3): 115–25. doi:10.1016/S0167-0115(02)00194-5. PMID 12409223.
  • Ronaldson E, Robertson DN, Johnson MS, Holland PJ, Mitchell R, Lutz EM (Nov 2002). "Specific interaction between the hop1 intracellular loop 3 domain of the human PAC(1) receptor and ARF". Regulatory Peptides. 109 (1–3): 193–8. doi:10.1016/S0167-0115(02)00204-5. PMID 12409233.
  • Isobe K, Tatsuno I, Yashiro T, Nanmoku T, Takekoshi K, Kawakami Y, Nakai T (Feb 2003). "Expression of mRNA for PACAP and its receptors in intra- and extra-adrenal human pheochromocytomas and their relationship to catecholamine synthesis". Regulatory Peptides. 110 (3): 213–7. doi:10.1016/S0167-0115(02)00209-4. PMID 12573802.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=ADCYAP1R1&oldid=1421552"