Masitinib

{{Drugbox | drug_name = | IUPAC_name = 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide | image = Masitinib Wiki str.png

| alt = | caption =

| tradename = Masivet, Kinavet | Drugs.com = International Drug Names | MedlinePlus = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =

| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion =

| CAS_number = 790299-79-5 | ATCvet = | ATC_prefix = L01 | ATC_suffix = XE22 | ATC_supplemental = | PubChem = 10074640 | ChEMBL = 1908391 | ChemSpiderID = 8250179 | DrugBank =

| C=28 | H=30 | N=6 | O=1 | S=1 | molecular_weight = 498.64 g/mol | smiles = O=C(c1ccc(cc1)CN2CCN(C)CC2)Nc3cc(c(cc3)C)Nc4nc(cs4)c5cccnc5 | StdInChI = InChI=1S/C28H30N6OSc1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) | StdInChIKey = WJEOLQLKVOPQFV-UHFFFAOYSA-N }}

WikiDoc Resources for Masitinib
Articles
Most recent articles on Masitinib Most cited articles on Masitinib Review articles on Masitinib Articles on Masitinib in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Masitinib Images of Masitinib Photos of Masitinib Podcasts & MP3s on Masitinib Videos on Masitinib
Evidence Based Medicine
Cochrane Collaboration on Masitinib Bandolier on Masitinib TRIP on Masitinib
Clinical Trials
Ongoing Trials on Masitinib at Clinical Trials.gov Trial results on Masitinib Clinical Trials on Masitinib at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Masitinib NICE Guidance on Masitinib NHS PRODIGY Guidance FDA on Masitinib CDC on Masitinib
Books
Books on Masitinib
News
Masitinib in the news Be alerted to news on Masitinib News trends on Masitinib
Commentary
Blogs on Masitinib
Definitions
Definitions of Masitinib
Patient Resources / Community
Patient resources on Masitinib Discussion groups on Masitinib Patient Handouts on Masitinib Directions to Hospitals Treating Masitinib Risk calculators and risk factors for Masitinib
Healthcare Provider Resources
Symptoms of Masitinib Causes & Risk Factors for Masitinib Diagnostic studies for Masitinib Treatment of Masitinib
Continuing Medical Education (CME)
CME Programs on Masitinib
International
Masitinib en Espanol Masitinib en Francais
Business
Masitinib in the Marketplace Patents on Masitinib
Experimental / Informatics
List of terms related to Masitinib

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.

Masitinib is being studied for several human conditions including cancers. It is used in Europe to fight orphan diseases.

Mechanism of action

Masitinib inhibits the receptor tyrosine kinase c-Kit which is displayed by various types of tumour. It also inhibits the platelet derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR).

References

Template:Antineoplastic-drug-stub