Phenylethanolamine N-methyltransferase

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phenylethanolamine N-methyltransferase
Identifiers
Symbol	PNMT
Alt. Symbols	PENT
Entrez	5409
HUGO	9160
OMIM	171190
RefSeq	NM_002686
UniProt	P11086
Other data
EC number	2.1.1.28
Locus	Chr. 17 q21-q22

Phenylethanolamine N-methyltransferase (PNMT) is an enzyme found in the adrenal medulla that converts Norepinephrine (Noradrenalin) to Epinephrine (Adrenalin).

PNMT is positively influenced by cortisol, which is produced in the adrenal cortex.

PNMT converts the last step in the synthesis of epinephrine

External links

v • d • e Transferase: one carbon transferases (EC 2.1)
2.1.1 - Methyltransferases	5-hydroxyindole-O-methyltransferase/Acetylserotonin O-methyltransferase - Betaine-homocysteine methyltransferase - Catechol-O-methyl transferase - Histamine N-methyltransferase - Homocysteine methyltransferase - 5-Methyltetrahydrofolate-homocysteine methyltransferase - Phosphatidyl ethanolamine methyltransferase - Phenylethanolamine N-methyltransferase - DNMT3B - Histone methyltransferase - Thymidylate synthase - Tryptamine N-methyltransferase - DNA methyltransferase
2.1.2 - Hydroxy methyl-, Formyl- and Related Transferases	Serine hydroxymethyltransferase - Phosphoribosylglycinamide formyltransferase - Inosine monophosphate synthase - Glutamate formimidoyltransferase - Aminomethyltransferase
2.1.3 - Carboxy- and Carbamoyl transferases	Ornithine transcarbamylase
2.1.4 - Amidino transferases	Arginine:glycine amidinotransferase

v • d • e

LYSINE→acetyl-CoA	Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase
LEUCINE→acetyl-CoA	Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase
TRYPTOPHAN→acetyl-CoA	Kynureninase
PHENYLALANINE→tyrosine→acetoacetate	(see below)

glycine→serine→pyruvate→TCA	Serine hydroxymethyltransferase - Serine dehydratase
alanine→pyruvate→TCA	Alanine transaminase
cysteine→pyruvate→TCA	D-cysteine desulfhydrase
threonine→pyruvate→TCA	L-threonine dehydrogenase
HISTIDINE→glutamate	Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase
proline→glutamate	Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1
arginine→glutamate	Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase
glutamate→alpha-ketoglutarate→TCA	Glutamate dehydrogenase
METHIONINE→propionyl-CoA	Methionine adenosyltransferase - Adenosylhomocysteinase - (or MTR/Homocysteine methyltransferase) - Cystathionine beta synthase - Cystathionine gamma-lyase
ISOLEUCINE/valine→propionyl-CoA	Branched-chain alpha-keto acid dehydrogenase complex

HISTIDINE→histamine	Histidine decarboxylase
tyrosine→dopamine→epinephrine	Tyrosine hydroxylase - Aromatic L-amino acid decarboxylase - Dopamine beta hydroxylase - Phenylethanolamine N-methyltransferase - Catechol-O-methyl transferase
glutamate→GABA	Glutamate decarboxylase
arginine→NO	Nitric oxide synthase

Other

tyrosine→melanin	Tyrosinase
TRYPTOPHAN→serotonin→melatonin	Tryptophan hydroxylase - Aromatic L-amino acid decarboxylase - Acetylserotonin O-methyltransferase
cysteine+glutamate→glutathione	Gamma-glutamylcysteine synthetase - Glutathione synthetase
glycine→creatine	Guanidinoacetate N-methyltransferase - Creatine kinase
glutamate→glutamine	Glutamine synthetase - Glutaminase
collagen	Prolyl hydroxylase - Lysyl hydroxylase